PCOLCE and COL3A1

Number of citations of the paper that reports this interaction (PMID 12105202)
10

Data Source:
HPRD (in vitro)

		PCOLCE	COL3A1
Gene Name		procollagen C-endopeptidase enhancer	collagen, type III, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Collagen Type III Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Proteolysis Multicellular Organismal Development Positive Regulation Of Peptidase Activity	Skeletal System Development Receptor-mediated Endocytosis Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Heart Development Aging Response To Radiation Response To Mechanical Stimulus Peptide Cross-linking Cerebral Cortex Development Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Response To Cytokine Positive Regulation Of Rho Protein Signal Transduction Wound Healing Extracellular Fibril Organization Skin Development Digestive Tract Development Negative Regulation Of Immune Response Aorta Smooth Muscle Tissue Morphogenesis Cellular Response To Amino Acid Stimulus Negative Regulation Of Neuron Migration
Pathways		Collagen formation Crosslinking of collagen fibrils Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Syndecan interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth Scavenging by Class A Receptors
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: COL2A1 COL3A1 ECT2 PLG	12 interactors: CAPN1 DDR1 DDR2 FGF7 HTRA1 MAG MYOC PCOLCE PDGFA PDGFB SPARC THBS1
Entrez ID		5118	1281
HPRD ID		02603	00365
Ensembl ID		ENSG00000106333	ENSG00000168542
Uniprot IDs		Q15113	P02461
PDB IDs		1UAP	2V53 3DMW 4AE2 4AEJ 4AK3 4GYX
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Fibril Organization Collagen Catabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cardiovascular System Development Cell Morphogenesis Platelet Activation Cell Differentiation Mononuclear Cell Migration Locomotion Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Aorta Smooth Muscle Tissue Morphogenesis Movement Of Cell Or Subcellular Component System Development Generation Of Neurons Regulation Of Rho Protein Signal Transduction Neurogenesis Tissue Development Axon Guidance Limb Bud Formation Negative Regulation Of Fibrinolysis Catabolic Process Multicellular Organismal Development Blood Coagulation Anatomical Structure Development Cellular Response To Organic Substance Hemostasis Extracellular Fibril Organization Response To Radiation Activation Of Rac GTPase Activity Regulation Of Fibrinolysis Embryonic Organ Development Muscle Structure Development Blood Vessel Development Heart Development Otic Vesicle Development Axonogenesis Developmental Process Vasculature Development Positive Regulation Of Cdc42 GTPase Activity Skeletal System Development Embryonic Skeletal Joint Morphogenesis Trophoblast Giant Cell Differentiation	Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell Proliferation Regulation Of Cell Migration Regulation Of Cell Motility Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Response To Wounding Regulation Of Cellular Component Movement Regulation Of Cellular Component Organization Platelet Degranulation Organ Development Positive Regulation Of Epithelial Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Organ Morphogenesis Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Wound Healing Regulation Of Epithelial Cell Proliferation Response To Growth Factor Multicellular Organismal Development Negative Regulation Of Phosphatidylinositol Biosynthetic Process Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Secretion Regulation Of Epithelial Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Developmental Process ERBB Signaling Pathway Blood Coagulation Collagen-activated Signaling Pathway Negative Regulation Of Phospholipid Biosynthetic Process System Development Positive Regulation Of Cell Proliferation Hemostasis Platelet Activation Positive Regulation Of Endothelial Cell Migration Neurotrophin TRK Receptor Signaling Pathway Platelet-derived Growth Factor Receptor-beta Signaling Pathway Secretion By Cell Neurotrophin Signaling Pathway Bone Development Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Anatomical Structure Development Positive Regulation Of Protein Kinase B Signaling
Tagcloud ?		apolipoprotein cathepsin cerebrospinal csf dbp dismutase electrophoresis electrospray endopeptidase epilepsy epileptogenesis fam3c igkv1 igl immunoglobulin ionization lambda lobe pathophysiologic proteomic sod1 spots superoxide talin tandem tetranectin tle tn	abrogation adenomas alcoholic ccl3 col1a2 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs2 socs3 steatosis superarray tgfbeta threefold tolerance unravel
Tagcloud (Difference) ?		apolipoprotein cathepsin cerebrospinal csf dbp dismutase electrophoresis electrospray endopeptidase epilepsy epileptogenesis fam3c igkv1 igl immunoglobulin ionization lambda lobe pathophysiologic proteomic sod1 spots superoxide talin tandem tetranectin tle tn	abrogation adenomas alcoholic ccl3 col1a2 compromised confirming fibrotic fivefold gh ghr ghrld hepatic hyperlipidemia livers microscopic mup1 nafld proteomics qpcr selenbp2 socs2 socs3 steatosis superarray tgfbeta threefold tolerance unravel
Tagcloud (Intersection) ?