PCOLCE and COL2A1

Number of citations of the paper that reports this interaction (PMID 12393877)
22

Data Source:
HPRD (in vitro)

		PCOLCE	COL2A1
Gene Name		procollagen C-endopeptidase enhancer	collagen, type II, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Collagen Type II Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity	Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Proteolysis Multicellular Organismal Development Positive Regulation Of Peptidase Activity	Skeletal System Development Cartilage Condensation Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Axon Guidance Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Notochord Development Inner Ear Morphogenesis Cartilage Development Palate Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Collagen formation Crosslinking of collagen fibrils Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: COL2A1 COL3A1 ECT2 PLG	33 interactors: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A
Entrez ID		5118	1280
HPRD ID		02603	00361
Ensembl ID		ENSG00000106333	ENSG00000139219
Uniprot IDs		Q15113	P02458
PDB IDs		1UAP	1U5M 2FSE 2SEB
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Fibril Organization Collagen Catabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cardiovascular System Development Cell Morphogenesis Platelet Activation Cell Differentiation Mononuclear Cell Migration Locomotion Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Aorta Smooth Muscle Tissue Morphogenesis Movement Of Cell Or Subcellular Component System Development Generation Of Neurons Regulation Of Rho Protein Signal Transduction Neurogenesis Tissue Development Axon Guidance Limb Bud Formation Negative Regulation Of Fibrinolysis Catabolic Process Multicellular Organismal Development Blood Coagulation Anatomical Structure Development Cellular Response To Organic Substance Hemostasis Extracellular Fibril Organization Response To Radiation Activation Of Rac GTPase Activity Regulation Of Fibrinolysis Embryonic Organ Development Muscle Structure Development Blood Vessel Development Heart Development Otic Vesicle Development Axonogenesis Developmental Process Vasculature Development Positive Regulation Of Cdc42 GTPase Activity Skeletal System Development Embryonic Skeletal Joint Morphogenesis Trophoblast Giant Cell Differentiation	Extracellular Matrix Organization Extracellular Structure Organization Connective Tissue Development Cartilage Development Skeletal System Development Anatomical Structure Morphogenesis Organ Morphogenesis System Development Multicellular Organismal Development Tissue Development Platelet Degranulation Anatomical Structure Development Positive Regulation Of Cell Migration Bone Development Developmental Process Positive Regulation Of Cell Motility Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Growth Plate Cartilage Development Response To Wounding Extracellular Matrix Disassembly Organ Development Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Cellular Response To Growth Factor Stimulus Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Hemostasis Response To Growth Factor Locomotion Collagen Catabolic Process Endochondral Bone Growth Regulation Of Epithelial Cell Migration Collagen Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Involved In Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Response To External Stimulus Regulation Of Cell Migration Organ Growth Platelet Activation Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Growth Positive Regulation Of Endothelial Cell Migration Regulation Of Locomotion Bone Morphogenesis
Tagcloud ?		apolipoprotein cathepsin cerebrospinal csf dbp dismutase electrophoresis electrospray endopeptidase epilepsy epileptogenesis fam3c igkv1 igl immunoglobulin ionization lambda lobe pathophysiologic proteomic sod1 spots superoxide talin tandem tetranectin tle tn	ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones
Tagcloud (Difference) ?		apolipoprotein cathepsin cerebrospinal csf dbp dismutase electrophoresis electrospray endopeptidase epilepsy epileptogenesis fam3c igkv1 igl immunoglobulin ionization lambda lobe pathophysiologic proteomic sod1 spots superoxide talin tandem tetranectin tle tn	ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones
Tagcloud (Intersection) ?