PCOLCE and COL2A1

Number of citations of the paper that reports this interaction (PubMedID 12393877)
0

Data Source:
HPRD (in vitro)

		PCOLCE	COL2A1
Description		procollagen C-endopeptidase enhancer	collagen type II alpha 1 chain
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type II Trimer Collagen Type XI Trimer Basement Membrane Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Peptidase Activator Activity	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength MHC Class II Protein Binding Identical Protein Binding Protein Homodimerization Activity Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Proteolysis Collagen Biosynthetic Process	Skeletal System Development Cartilage Condensation Ossification Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Collagen Fibril Organization Notochord Development Limb Morphogenesis Inner Ear Morphogenesis Animal Organ Development Skeletal System Morphogenesis System Development Inner Ear Development Cartilage Development Roof Of Mouth Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Bone Development Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Anterior Head Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Collagen biosynthesis and modifying enzymes Crosslinking of collagen fibrils	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells
Drugs			Collagenase clostridium histolyticum
Diseases			Osteoarthritis with mild chondrodysplasia Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Type II collagenopathies, including: Achondrogenesis II; Hypochondrogenesis; SED congenita; SMED Strudwick type; Kniest dysplasia; Spondyloperipheral dysplasia; Osteoarthritis with mild chondrodysplasia; Stickler syndrome 1; Platyspondylic skeletal dysplasia, Torrance type; Epiphyseal dysplasia, multiple, with myopia and deafness; Czech dysplasia
GWAS		Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Resting heart rate ( 27798624) Subcortical volume (MOSTest) ( 32665545)	Lymphocyte count ( 32888494) Macular thickness ( 30535121) Neutrophil percentage of white cells ( 32888494) Retinal detachment or retinal break ( 31816047) Rheumatoid arthritis ( 30891314) Triglyceride levels ( 32902719)
Interacting Genes		5 interacting genes: COL2A1 COL3A1 ECT2 HMGB1 PLG	33 interacting genes: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B KEAP1 LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A
Entrez ID		5118	1280
HPRD ID		02603	00361
Ensembl ID		ENSG00000106333	ENSG00000139219
Uniprot IDs		Q15113	P02458
PDB IDs		1UAP 6FZV 6FZW 9EN2	1U5M 2FSE 2SEB 5NIR 5OCX 5OCY 6BIN 6HG7 6NIX 7NZE
Enriched GO Terms of Interacting Partners?		Fibrillar Collagen Trimer Extracellular Matrix Platelet-derived Growth Factor Binding Cell Differentiation Layer Formation In Cerebral Cortex Cellular Developmental Process Animal Organ Development Extracellular Space Extracellular Matrix Organization Regulation Of Cell Communication Extracellular Structure Organization Regulation Of Signaling Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Small GTPase Mediated Signal Transduction Cell Migration Regulation Of Neuron Migration Extracellular Region Regulation Of Cell Migration Collagen Fibril Organization Chondrocyte Differentiation System Development Regulation Of Cell Motility Regulation Of Locomotion Cell Motility Positive Regulation Of Wound Healing Positive Regulation Of Blood Vessel Endothelial Cell Migration Collagen Trimer Collagen Type III Trimer Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Lateral Motor Column Neuron Migration Reelin Complex Spinal Cord Patterning Cerebral Cortex Development Lung Development Cartilage Development Protease Binding Mononuclear Cell Migration Anatomical Structure Morphogenesis Developmental Process Extracellular Matrix Structural Constituent Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Endothelial Cell Migration	Extracellular Matrix Extracellular Region Collagen Binding Extracellular Matrix Structural Constituent Extracellular Space Animal Organ Development Cartilage Development Extracellular Matrix Binding Platelet Alpha Granule Lumen Developmental Process Cell Surface Extracellular Matrix Organization Extracellular Structure Organization Animal Organ Morphogenesis Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Response To Wounding Anatomical Structure Morphogenesis Bone Development Heparin Binding Positive Regulation Of Cell Migration Positive Regulation Of Glial Cell Differentiation Basement Membrane Positive Regulation Of Cell Motility Platelet-derived Growth Factor Binding Golgi Lumen Tube Morphogenesis Positive Regulation Of Locomotion Angiogenesis Regulation Of Cell Adhesion Extracellular Exosome Proteoglycan Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Skin Development Regulation Of Anatomical Structure Morphogenesis Cell Adhesion Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Bone Mineralization Positive Regulation Of MiRNA Transcription Positive Regulation Of Fibroblast Proliferation Chondrocyte Differentiation Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Gliogenesis Positive Regulation Of Phosphorylation Collagen Metabolic Process Regulation Of Extracellular Matrix Organization Regulation Of Glial Cell Differentiation Connective Tissue Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?