MTDH and NPC1

Number of citations of the paper that reports this interaction (PubMedID 22199357)
32

Data Source:
BioGRID (unspecified method)

		MTDH	NPC1
Description		metadherin	NPC intracellular cholesterol transporter 1
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Nuclear Body Nuclear Membrane Intercellular Canaliculus Perinuclear Region Of Cytoplasm Anchoring Junction	Extracellular Region Nuclear Envelope Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Late Endosome Membrane Vesicle Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Protein Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Virus Receptor Activity Transmembrane Signaling Receptor Activity Lipid Transporter Activity Protein Binding Cholesterol Binding Signaling Receptor Activity Cholesterol Transfer Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Autophagy Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Liver Development Protein Glycosylation Lipid Metabolic Process Lipid Transport Endocytosis Autophagy Lysosomal Transport Adult Walking Behavior Steroid Metabolic Process Cholesterol Metabolic Process Bile Acid Metabolic Process Response To Xenobiotic Stimulus Gene Expression Cholesterol Storage Programmed Cell Death Sterol Transport Sterol Metabolic Process Macroautophagy Negative Regulation Of Macroautophagy Neurogenesis Intestinal Cholesterol Absorption Cholesterol Transport Membrane Raft Organization Intracellular Lipid Transport Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Response To Cadmium Ion Symbiont Entry Into Host Cell Establishment Of Localization In Cell Cellular Response To Steroid Hormone Stimulus Cellular Response To Low-density Lipoprotein Particle Stimulus Establishment Of Protein Localization To Membrane Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of TORC1 Signaling Cyclodextrin Metabolic Process
Pathways			LDL clearance
Drugs
Diseases			Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Migraine ( 20802479) Nicotine metabolite ratio in current smokers ( 27488534) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 27863252 28957414 32888494) Sweet taste preference ( 32572145)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Body mass index ( 29273807) Body size at age 10 ( 32376654) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778) Granulocyte count ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Household income (MTAG) ( 31844048) Mental health study participation (provided email address) ( 31263887) Metabolic syndrome ( 31589552) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Obesity ( 19151714) Poultry consumption ( 32066663) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Triglyceride levels ( 32154731 32203549) Triglycerides ( 30275531) Walking pace ( 33128006) White blood cell count ( 27863252)
Interacting Genes		175 interacting genes: ABCA12 ABCC3 ABTB1 ACTN1 ADCK2 ADGRA2 AGAP3 ALOX5 ANKRD13D ANKRD26P1 ANPEP ARNT2 ARRDC1 AXL BCAS3 BCS1L CAPN2 CARD8 CCL20 CCN2 CCNDBP1 CCT4 CD109 CD22 CDC14B CDC42 CEP162 CLCN7 CLDN2 CLMN COL13A1 COL4A4 COL6A1 CPAP CPT2 CRIM1 CSNK2A1 CTSB CUL7 CUL9 CYFIP2 CYP27A1 CYP4V2 DMTF1 DNAH5 DNAI4 DOCK2 DOP1B DSP DUSP5 ECE1 EGFR EGR1 ELN EML1 EPHB1 EPHX2 ERCC2 ERICH6B ESAM FAM184A FANCI FASN FCGRT FLNA FLNC FN1 FOXM1 GHDC GLG1 GRID1 HACE1 HERC5 HSPG2 ICA1L IFT46 IKBKB IL17RA IL2RB IPO9 IRS2 ITGB5 ITPR3 JADE3 JAG1 KCNH1 KCNQ5 KDM6A KMT2B LAMA5 LDLRAD2 LOXL4 LRIG3 LRP1 LRP5 MAP3K12 MCM6 MEGF11 METTL3 MLPH MMP2 MNT MRC2 MRPL39 MYH9 MYL5 NEB NEO1 NFKB2 NOTCH3 NPC1 NPR1 NUP210 NXF4 OBSCN OGT OR8G5 OSMR PCCB PCDH7 PKN1 PLAT PLD2 PLEC PLEKHO2 PLXNA3 PPFIA2 PRICKLE4 PSIP1 PTHLH PWP2 RAB24 RGS13 RIN1 RIPK1 RNF123 RNF213 RSPO3 RYR1 SDK1 SELENOI SEZ6L2 SGSM2 SH2B2 SIAE SLC38A4 SLC67A1-AS SPEF2 SPRED2 SPTBN5 SQSTM1 SSH3 STEAP3 STK25 STXBP1 SYNE1 TACR2 TBC1D2B TBCD TCIRG1 TEP1 THBS1 THSD4 TINAGL1 TNS2 TOPORS TRAPPC12 TRPC4AP TUBB3 UBXN7 VIM WDFY2 WNK2 ZNF559 ZXDC	6 interacting genes: BUD31 DYRK1A GPR35 MC4R MTDH VPS4A
Entrez ID		92140	4864
HPRD ID		17459	09622
Ensembl ID		ENSG00000147649	ENSG00000141458
Uniprot IDs		Q86UE4	O15118
PDB IDs		4QMG	3GKH 3GKI 3GKJ 3JD8 5F18 5F1B 5HNS 5JNX 5KWY 5U73 5U74 6UOX 6W5R 6W5S 6W5T 6W5U 6W5V 8EUS 9DZ2
Enriched GO Terms of Interacting Partners?		Anatomical Structure Formation Involved In Morphogenesis Plasma Membrane Developmental Process Cell Adhesion Extracellular Exosome Cell Surface Receptor Signaling Pathway Angiogenesis Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Receptor Complex Myoblast Fusion Regulation Of Cellular Component Organization Cell Migration Actin Cytoskeleton Organization Cytoskeleton Organization Extracellular Matrix Endodermal Cell Differentiation Actin Filament Binding Homotypic Cell-cell Adhesion Cell-cell Adhesion Z Disc Regulation Of Signaling Cell Motility Ameboidal-type Cell Migration Actin Filament-based Process Membrane Protein Maturation Collagen V Binding Organelle Organization Focal Adhesion Signal Transduction Integrin Binding Cell Morphogenesis Regulation Of Cell Communication Hair Cycle Process Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Cytoskeleton Extracellular Matrix Structural Constituent Skin Development Virus Receptor Activity Cell-substrate Adhesion Golgi Organization Symbiont Entry Into Host Cell Tissue Remodeling Sarcomere Proteoglycan Binding Insulin-like Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway	Positive Regulation Of Viral Life Cycle Transcription Coactivator Activity Histone H3T45 Kinase Activity Response To Melanocyte-stimulating Hormone Negative Regulation Of Nerve Growth Factor Production Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Dibasic Protein Processing Positive Regulation Of Viral Process Zymogen Inhibition Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Actomyosin Contractile Ring Contraction Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Contractile Ring Contraction Regulation Of Viral Life Cycle Melanocyte-stimulating Hormone Receptor Activity Negative Regulation Of Receptor Catabolic Process Positive Regulation Of Viral Budding Via Host ESCRT Complex Regulation Of Viral Process Viral Translation Viral Life Cycle Viral Process Mitotic Cytokinesis Checkpoint Signaling Centrosome Negative Regulation Of Heterochromatin Formation Melanocortin Receptor Activity Cytokine Precursor Processing Biological Process Involved In Interaction With Host Nerve Growth Factor Binding Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Negative Regulation Of Transforming Growth Factor Beta1 Production ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Intercellular Canaliculus Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Cytokinesis C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Eating Behavior Heparan Sulfate Binding Regulation Of Heterochromatin Formation Signal Peptide Processing RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Mitotic Nuclear Membrane Reassembly
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?