MTDH and NPR1

Number of citations of the paper that reports this interaction (PubMedID 22199357)
32

Data Source:
BioGRID (unspecified method)

		MTDH	NPR1
Description		metadherin	natriuretic peptide receptor 1
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Nuclear Body Nuclear Membrane Intercellular Canaliculus Perinuclear Region Of Cytoplasm Anchoring Junction	Plasma Membrane Membrane Receptor Complex ANPR-A Receptor Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Protein Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Nucleotide Binding Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity ATP Binding GTP Binding G Protein-coupled Peptide Receptor Activity Lyase Activity Phosphorus-oxygen Lyase Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Autophagy Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	CGMP Biosynthetic Process Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Body Fluid Secretion Blood Circulation Regulation Of Blood Pressure Cyclic Nucleotide Biosynthetic Process Positive Regulation Of CGMP-mediated Signaling Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Dopamine Metabolic Process Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Cell Proliferation Blood Vessel Diameter Maintenance
Pathways			Physiological factors
Drugs			Nitroprusside Nitroglycerin Isosorbide dinitrate Amyl Nitrite Erythrityl tetranitrate Nesiritide Ularitide
Diseases
GWAS		Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Migraine ( 20802479) Nicotine metabolite ratio in current smokers ( 27488534) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 27863252 28957414 32888494) Sweet taste preference ( 32572145)	Mean arterial pressure ( 27618448) Systolic blood pressure ( 27618448)
Interacting Genes		175 interacting genes: ABCA12 ABCC3 ABTB1 ACTN1 ADCK2 ADGRA2 AGAP3 ALOX5 ANKRD13D ANKRD26P1 ANPEP ARNT2 ARRDC1 AXL BCAS3 BCS1L CAPN2 CARD8 CCL20 CCN2 CCNDBP1 CCT4 CD109 CD22 CDC14B CDC42 CEP162 CLCN7 CLDN2 CLMN COL13A1 COL4A4 COL6A1 CPAP CPT2 CRIM1 CSNK2A1 CTSB CUL7 CUL9 CYFIP2 CYP27A1 CYP4V2 DMTF1 DNAH5 DNAI4 DOCK2 DOP1B DSP DUSP5 ECE1 EGFR EGR1 ELN EML1 EPHB1 EPHX2 ERCC2 ERICH6B ESAM FAM184A FANCI FASN FCGRT FLNA FLNC FN1 FOXM1 GHDC GLG1 GRID1 HACE1 HERC5 HSPG2 ICA1L IFT46 IKBKB IL17RA IL2RB IPO9 IRS2 ITGB5 ITPR3 JADE3 JAG1 KCNH1 KCNQ5 KDM6A KMT2B LAMA5 LDLRAD2 LOXL4 LRIG3 LRP1 LRP5 MAP3K12 MCM6 MEGF11 METTL3 MLPH MMP2 MNT MRC2 MRPL39 MYH9 MYL5 NEB NEO1 NFKB2 NOTCH3 NPC1 NPR1 NUP210 NXF4 OBSCN OGT OR8G5 OSMR PCCB PCDH7 PKN1 PLAT PLD2 PLEC PLEKHO2 PLXNA3 PPFIA2 PRICKLE4 PSIP1 PTHLH PWP2 RAB24 RGS13 RIN1 RIPK1 RNF123 RNF213 RSPO3 RYR1 SDK1 SELENOI SEZ6L2 SGSM2 SH2B2 SIAE SLC38A4 SLC67A1-AS SPEF2 SPRED2 SPTBN5 SQSTM1 SSH3 STEAP3 STK25 STXBP1 SYNE1 TACR2 TBC1D2B TBCD TCIRG1 TEP1 THBS1 THSD4 TINAGL1 TNS2 TOPORS TRAPPC12 TRPC4AP TUBB3 UBXN7 VIM WDFY2 WNK2 ZNF559 ZXDC	7 interacting genes: ATF7IP MTDH NPPA NPPB NPPC PRKG1 UBE2D2
Entrez ID		92140	4881
HPRD ID		17459	00165
Ensembl ID		ENSG00000147649	ENSG00000169418
Uniprot IDs		Q86UE4	A0A140VJE6 P16066
PDB IDs		4QMG	8TG9 8TGA 9BCL 9BCN 9BCO 9BCP 9BCQ 9BCS 9BCV
Enriched GO Terms of Interacting Partners?		Anatomical Structure Formation Involved In Morphogenesis Plasma Membrane Developmental Process Cell Adhesion Extracellular Exosome Cell Surface Receptor Signaling Pathway Angiogenesis Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Receptor Complex Myoblast Fusion Regulation Of Cellular Component Organization Cell Migration Actin Cytoskeleton Organization Cytoskeleton Organization Extracellular Matrix Endodermal Cell Differentiation Actin Filament Binding Homotypic Cell-cell Adhesion Cell-cell Adhesion Z Disc Regulation Of Signaling Cell Motility Ameboidal-type Cell Migration Actin Filament-based Process Membrane Protein Maturation Collagen V Binding Organelle Organization Focal Adhesion Signal Transduction Integrin Binding Cell Morphogenesis Regulation Of Cell Communication Hair Cycle Process Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Cytoskeleton Extracellular Matrix Structural Constituent Skin Development Virus Receptor Activity Cell-substrate Adhesion Golgi Organization Symbiont Entry Into Host Cell Tissue Remodeling Sarcomere Proteoglycan Binding Insulin-like Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway	Hormone Receptor Binding CGMP-mediated Signaling Guanylate Cyclase Activator Activity Receptor Guanylyl Cyclase Signaling Pathway CGMP Biosynthetic Process CGMP Metabolic Process Cyclic Nucleotide Biosynthetic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Cyclic Purine Nucleotide Metabolic Process Regulation Of Vascular Permeability Vasodilation Vascular Process In Circulatory System Positive Regulation Of CGMP-mediated Signaling Circulatory System Process Cell Growth Involved In Cardiac Muscle Cell Development Hormone Activity Regulation Of CGMP-mediated Signaling Purine Ribonucleotide Biosynthetic Process Cardiac Conduction System Development Bone Growth Ribose Phosphate Biosynthetic Process Purine Nucleotide Biosynthetic Process Negative Regulation Of Systemic Arterial Blood Pressure Nucleotide Biosynthetic Process Protein Folding Purine-containing Compound Biosynthetic Process Protein-containing Complex Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Negative Regulation Of Blood Pressure Organ Growth Ribonucleotide Metabolic Process Intracellular Signaling Cassette Ribose Phosphate Metabolic Process Cardiac Muscle Tissue Development Purine Nucleotide Metabolic Process Developmental Growth Negative Regulation Of Collecting Lymphatic Vessel Constriction Signaling Receptor Binding Diuretic Hormone Activity Nucleotide Metabolic Process Carbohydrate Derivative Biosynthetic Process Neuropeptide Signaling Pathway Neuropeptide Receptor Binding Response To 3-methylcholanthrene Purine-containing Compound Metabolic Process Cumulus Cell Differentiation C-di-GMP Signaling Multicellular Organismal Locomotion
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