MTDH and IL17RA

Number of citations of the paper that reports this interaction (PubMedID 22199357)
32

Data Source:
BioGRID (unspecified method)

		MTDH	IL17RA
Description		metadherin	interleukin 17 receptor A
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Nuclear Body Nuclear Membrane Intercellular Canaliculus Perinuclear Region Of Cytoplasm Anchoring Junction	Extracellular Region Plasma Membrane Membrane
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Protein Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Signaling Receptor Binding Protein Binding Interleukin-17 Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Autophagy Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Adaptive Immune Response Immune System Process Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Virus Protein Catabolic Process Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-17A-mediated Signaling Pathway Innate Immune Response Positive Regulation Of Inflammatory Response Defense Response To Fungus Granulocyte Chemotaxis Fibroblast Activation T-helper 17 Type Immune Response Interleukin-17-mediated Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Pathways			Interleukin-17 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases			Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Migraine ( 20802479) Nicotine metabolite ratio in current smokers ( 27488534) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 27863252 28957414 32888494) Sweet taste preference ( 32572145)	Blood protein levels ( 30072576) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Heschl's gyrus morphology ( 25130324) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) White blood cell count ( 27863252 32888494)
Interacting Genes		175 interacting genes: ABCA12 ABCC3 ABTB1 ACTN1 ADCK2 ADGRA2 AGAP3 ALOX5 ANKRD13D ANKRD26P1 ANPEP ARNT2 ARRDC1 AXL BCAS3 BCS1L CAPN2 CARD8 CCL20 CCN2 CCNDBP1 CCT4 CD109 CD22 CDC14B CDC42 CEP162 CLCN7 CLDN2 CLMN COL13A1 COL4A4 COL6A1 CPAP CPT2 CRIM1 CSNK2A1 CTSB CUL7 CUL9 CYFIP2 CYP27A1 CYP4V2 DMTF1 DNAH5 DNAI4 DOCK2 DOP1B DSP DUSP5 ECE1 EGFR EGR1 ELN EML1 EPHB1 EPHX2 ERCC2 ERICH6B ESAM FAM184A FANCI FASN FCGRT FLNA FLNC FN1 FOXM1 GHDC GLG1 GRID1 HACE1 HERC5 HSPG2 ICA1L IFT46 IKBKB IL17RA IL2RB IPO9 IRS2 ITGB5 ITPR3 JADE3 JAG1 KCNH1 KCNQ5 KDM6A KMT2B LAMA5 LDLRAD2 LOXL4 LRIG3 LRP1 LRP5 MAP3K12 MCM6 MEGF11 METTL3 MLPH MMP2 MNT MRC2 MRPL39 MYH9 MYL5 NEB NEO1 NFKB2 NOTCH3 NPC1 NPR1 NUP210 NXF4 OBSCN OGT OR8G5 OSMR PCCB PCDH7 PKN1 PLAT PLD2 PLEC PLEKHO2 PLXNA3 PPFIA2 PRICKLE4 PSIP1 PTHLH PWP2 RAB24 RGS13 RIN1 RIPK1 RNF123 RNF213 RSPO3 RYR1 SDK1 SELENOI SEZ6L2 SGSM2 SH2B2 SIAE SLC38A4 SLC67A1-AS SPEF2 SPRED2 SPTBN5 SQSTM1 SSH3 STEAP3 STK25 STXBP1 SYNE1 TACR2 TBC1D2B TBCD TCIRG1 TEP1 THBS1 THSD4 TINAGL1 TNS2 TOPORS TRAPPC12 TRPC4AP TUBB3 UBXN7 VIM WDFY2 WNK2 ZNF559 ZXDC	2 interacting genes: IL17A MTDH
Entrez ID		92140	23765
HPRD ID		17459	10399
Ensembl ID		ENSG00000147649	ENSG00000177663
Uniprot IDs		Q86UE4	Q96F46
PDB IDs		4QMG	3JVF 4HSA 4NUX 5N9B 5NAN 7UWL 7UWM 7UWN 7ZAN
Enriched GO Terms of Interacting Partners?		Anatomical Structure Formation Involved In Morphogenesis Plasma Membrane Developmental Process Cell Adhesion Extracellular Exosome Cell Surface Receptor Signaling Pathway Angiogenesis Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Receptor Complex Myoblast Fusion Regulation Of Cellular Component Organization Cell Migration Actin Cytoskeleton Organization Cytoskeleton Organization Extracellular Matrix Endodermal Cell Differentiation Actin Filament Binding Homotypic Cell-cell Adhesion Cell-cell Adhesion Z Disc Regulation Of Signaling Cell Motility Ameboidal-type Cell Migration Actin Filament-based Process Membrane Protein Maturation Collagen V Binding Organelle Organization Focal Adhesion Signal Transduction Integrin Binding Cell Morphogenesis Regulation Of Cell Communication Hair Cycle Process Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Cytoskeleton Extracellular Matrix Structural Constituent Skin Development Virus Receptor Activity Cell-substrate Adhesion Golgi Organization Symbiont Entry Into Host Cell Tissue Remodeling Sarcomere Proteoglycan Binding Insulin-like Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway
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