MTDH and EPHX2

Number of citations of the paper that reports this interaction (PubMedID 22199357)
32

Data Source:
BioGRID (unspecified method)

		MTDH	EPHX2
Description		metadherin	epoxide hydrolase 2
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Nuclear Body Nuclear Membrane Intercellular Canaliculus Perinuclear Region Of Cytoplasm Anchoring Junction	Cytoplasm Peroxisome Peroxisomal Matrix Cytosol Extracellular Exosome
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Protein Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Magnesium Ion Binding Catalytic Activity Epoxide Hydrolase Activity Toxic Substance Binding Hydrolase Activity Phosphatase Activity 10-hydroxy-9-(phosphonooxy)octadecanoate Phosphatase Activity Lipid Phosphatase Activity Protein Homodimerization Activity Metal Ion Binding Lysophosphatidic Acid Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Autophagy Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Regulation Of Cell Growth Lipid Metabolic Process Response To Toxic Substance Positive Regulation Of Gene Expression Dephosphorylation Cholesterol Homeostasis Stilbene Catabolic Process Phospholipid Dephosphorylation Regulation Of Cholesterol Metabolic Process Epoxide Metabolic Process
Pathways			Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Biosynthesis of maresins Peroxisomal protein import Peroxisomal protein import
Drugs			N-Cyclohexyl-N'-(4-Iodophenyl)Urea N-Cyclohexyl-N'-Decylurea N-Cyclohexyl-N'-(Propyl)Phenyl Urea AR-9281 N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINE 4-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACID 6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID 7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACID Ebselen
Diseases
GWAS		Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Migraine ( 20802479) Nicotine metabolite ratio in current smokers ( 27488534) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 27863252 28957414 32888494) Sweet taste preference ( 32572145)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Cannabis use disorder ( 33096046) Crohn's disease ( 26192919) Dental caries ( 23259602) Inflammatory bowel disease ( 26192919) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Schizophrenia ( 29483656 25056061) Smoking behaviour (cigarettes smoked per day) ( 31089300) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		175 interacting genes: ABCA12 ABCC3 ABTB1 ACTN1 ADCK2 ADGRA2 AGAP3 ALOX5 ANKRD13D ANKRD26P1 ANPEP ARNT2 ARRDC1 AXL BCAS3 BCS1L CAPN2 CARD8 CCL20 CCN2 CCNDBP1 CCT4 CD109 CD22 CDC14B CDC42 CEP162 CLCN7 CLDN2 CLMN COL13A1 COL4A4 COL6A1 CPAP CPT2 CRIM1 CSNK2A1 CTSB CUL7 CUL9 CYFIP2 CYP27A1 CYP4V2 DMTF1 DNAH5 DNAI4 DOCK2 DOP1B DSP DUSP5 ECE1 EGFR EGR1 ELN EML1 EPHB1 EPHX2 ERCC2 ERICH6B ESAM FAM184A FANCI FASN FCGRT FLNA FLNC FN1 FOXM1 GHDC GLG1 GRID1 HACE1 HERC5 HSPG2 ICA1L IFT46 IKBKB IL17RA IL2RB IPO9 IRS2 ITGB5 ITPR3 JADE3 JAG1 KCNH1 KCNQ5 KDM6A KMT2B LAMA5 LDLRAD2 LOXL4 LRIG3 LRP1 LRP5 MAP3K12 MCM6 MEGF11 METTL3 MLPH MMP2 MNT MRC2 MRPL39 MYH9 MYL5 NEB NEO1 NFKB2 NOTCH3 NPC1 NPR1 NUP210 NXF4 OBSCN OGT OR8G5 OSMR PCCB PCDH7 PKN1 PLAT PLD2 PLEC PLEKHO2 PLXNA3 PPFIA2 PRICKLE4 PSIP1 PTHLH PWP2 RAB24 RGS13 RIN1 RIPK1 RNF123 RNF213 RSPO3 RYR1 SDK1 SELENOI SEZ6L2 SGSM2 SH2B2 SIAE SLC38A4 SLC67A1-AS SPEF2 SPRED2 SPTBN5 SQSTM1 SSH3 STEAP3 STK25 STXBP1 SYNE1 TACR2 TBC1D2B TBCD TCIRG1 TEP1 THBS1 THSD4 TINAGL1 TNS2 TOPORS TRAPPC12 TRPC4AP TUBB3 UBXN7 VIM WDFY2 WNK2 ZNF559 ZXDC	5 interacting genes: MTDH MVP NIPSNAP3A PEX5 TERF1
Entrez ID		92140	2053
HPRD ID		17459	00582
Ensembl ID		ENSG00000147649	ENSG00000120915
Uniprot IDs		Q86UE4	E5RFU2 P34913
PDB IDs		4QMG	1S8O 1VJ5 1ZD2 1ZD3 1ZD4 1ZD5 3ANS 3ANT 3I1Y 3I28 3KOO 3OTQ 3PDC 3WK4 3WK5 3WK6 3WK7 3WK8 3WK9 3WKA 3WKB 3WKC 3WKD 3WKE 4C4X 4C4Y 4C4Z 4HAI 4J03 4JNC 4OCZ 4OD0 4X6X 4X6Y 4Y2J 4Y2P 4Y2Q 4Y2R 4Y2S 4Y2T 4Y2U 4Y2V 4Y2X 4Y2Y 5AHX 5AI0 5AI4 5AI5 5AI6 5AI8 5AI9 5AIA 5AIB 5AIC 5AK3 5AK4 5AK5 5AK6 5AKE 5AKG 5AKH 5AKI 5AKJ 5AKK 5AKL 5AKX 5AKY 5AKZ 5ALD 5ALE 5ALF 5ALG 5ALH 5ALI 5ALJ 5ALK 5ALL 5ALM 5ALN 5ALO 5ALP 5ALQ 5ALR 5ALS 5ALT 5ALU 5ALV 5ALW 5ALX 5ALY 5ALZ 5AM0 5AM1 5AM2 5AM3 5AM4 5AM5 5FP0 5MWA 6AUM 6I5E 6I5G 7EBA 8QVF 8QVG 8QVH 8QVK 8QVL 8QVM 8QWG 8QWI 8ZBL
Enriched GO Terms of Interacting Partners?		Anatomical Structure Formation Involved In Morphogenesis Plasma Membrane Developmental Process Cell Adhesion Extracellular Exosome Cell Surface Receptor Signaling Pathway Angiogenesis Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Receptor Complex Myoblast Fusion Regulation Of Cellular Component Organization Cell Migration Actin Cytoskeleton Organization Cytoskeleton Organization Extracellular Matrix Endodermal Cell Differentiation Actin Filament Binding Homotypic Cell-cell Adhesion Cell-cell Adhesion Z Disc Regulation Of Signaling Cell Motility Ameboidal-type Cell Migration Actin Filament-based Process Membrane Protein Maturation Collagen V Binding Organelle Organization Focal Adhesion Signal Transduction Integrin Binding Cell Morphogenesis Regulation Of Cell Communication Hair Cycle Process Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Cytoskeleton Extracellular Matrix Structural Constituent Skin Development Virus Receptor Activity Cell-substrate Adhesion Golgi Organization Symbiont Entry Into Host Cell Tissue Remodeling Sarcomere Proteoglycan Binding Insulin-like Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway	Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Shelterin Complex Assembly Macroautophagy Peroxisome Targeting Sequence Binding Fibrillar Center Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Negative Regulation Of Protein Autophosphorylation Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Intercellular Canaliculus Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Ankyrin Repeat Binding Autophagy Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Nuclear Telomere Cap Complex Telomere Localization Meiotic Telomere Clustering Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Protein Unfolding T-circle Formation Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Protein Import Into Peroxisome Matrix Nuclear Body DNA Binding, Bending Pexophagy Peroxisomal Membrane Transport Regulation Of Protein-containing Complex Assembly Establishment Of Protein Localization To Peroxisome Cerebral Cortex Neuron Differentiation Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Negative Regulation Of Peptidyl-tyrosine Phosphorylation
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