BRD7 and PTPN13

Number of citations of the paper that reports this interaction (PubMedID 10526152)
0

Data Source:
HPRD (two hybrid, in vivo)

		BRD7	PTPN13
Description		bromodomain containing 7	protein tyrosine phosphatase non-receptor type 13
Image
GO Annotations	Cellular Component	Kinetochore Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Matrix RSC-type Complex	Nucleus Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium Cell Projection Cell Body Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Histone Binding Histone H3K14ac Reader Activity Histone Reader Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatidylinositol 3-kinase Regulatory Subunit Binding
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Wnt Signaling Pathway Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Toxic Substance Negative Regulation Of Excitatory Synapse Assembly
Pathways		Regulation of TP53 Activity through Acetylation Formation of the polybromo-BAF (pBAF) complex	Synthesis of PIPs at the plasma membrane Interleukin-37 signaling RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS		Allergic sensitization ( 30013184) Epilepsy ( 30531953) Liver enzyme levels (alanine transaminase) ( 24124411) Medication use (thyroid preparations) ( 31015401)	Appendicular lean mass ( 33097823) Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Kidney disease (end stage renal disease vs normoalbuminuria) in type 1 diabetes ( 27647854) Tinnitus ( 33742053) Word spelling ( 30741946)
Interacting Genes		30 interacting genes: AGR2 BARD1 BHLHE40 BRD3 BTBD2 DVL1 FTH1 H2AC16 H2BC21 H3-3A H3-4 H3C14 H4C16 HAP1 HNRNPUL1 IRF2 LAMA4 LRIF1 MX1 NEFL PAFAH1B3 PARP1 PCBD1 PLEKHF2 PSMD11 PTPN13 RIF1 RPLP1 SERPINB9 TRIM24	26 interacting genes: APC ARHGAP29 BEX3 BRD7 CRHR1 CRIP2 CTNNB1 DSCAM EFNB1 EFNB2 FADD FAS FASLG GHR MTNR1A NFKBIA NGFR PDLIM4 PKN2 PLEKHA1 PLEKHA2 PRKACA RAPGEF6 TRIP6 VANGL2 YWHAZ
Entrez ID		29117	5783
HPRD ID		12531	02602
Ensembl ID		ENSG00000166164	ENSG00000163629
Uniprot IDs		A0AA34QVS2 Q9NPI1	Q12923
PDB IDs		2I7K 5MQ1 6PPA 6V0Q 6V16 6V17 6V1E 6V1F 6V1H 7VDV 7Y8R	1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ 5GLJ 7QCX 7QCY 7XTY
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome Chromosome Chromosome, Telomeric Region Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly Nucleus Barr Body Telomere Organization Negative Regulation Of Metabolic Process Protein Localization To Chromatin Heterochromatin Formation Subtelomeric Heterochromatin Formation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Nucleoplasm Chromatin Cellular Response To Estrogen Stimulus Extracellular Exosome Retrograde Axonal Transport Protein Binding Protein Localization To Chromosome NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Negative Regulation Of MRNA 3'-end Processing Epigenetic Regulation Of Gene Expression Histone H3K9cr Reader Activity Histone H3K27cr Reader Activity Histone H3K18cr Reader Activity Histone H3K23ac Reader Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neurotrophin Production Positive Regulation Of ERBB Signaling Pathway Chromosome, Telomeric Repeat Region Regulation Of Developmental Process Growth Cone Response To Mineralocorticoid	Signal Transduction Cell Surface Receptor Signaling Pathway Plasma Membrane Necroptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Death Receptor Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signaling Cassette Ubiquitin Protein Ligase Binding Apoptotic Signaling Pathway Protein Phosphatase Binding Glutamatergic Synapse Neuron Projection Guidance Axon Guidance Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction CD95 Death-inducing Signaling Complex Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Cell Junction Assembly Positive Regulation Of Cell Population Proliferation Tube Formation Death-inducing Signaling Complex Cell Junction Organization Positive Regulation Of Apoptotic Signaling Pathway Cellular Component Assembly Regulation Of Intracellular Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Cell Population Proliferation Regulation Of Developmental Process Positive Regulation Of Cell Adhesion Cellular Developmental Process Cell-cell Junction Organization Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Beta-catenin Destruction Complex Positive Regulation Of Apoptotic Process Lateral Plasma Membrane Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Cell Projection Organization Rho Protein Signal Transduction Wnt Signalosome Adherens Junction Nervous System Development Lamellipodium
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