BRD7 and PTPN13

Number of citations of the paper that reports this interaction (PMID 10526152)
2

Data Source:
HPRD (in vivo, two hybrid)

		BRD7	PTPN13
Gene Name		bromodomain containing 7	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium Neuron Projection Cell Body Extracellular Vesicular Exosome
	Molecular Function	P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Histone Binding Transcription Regulatory Region DNA Binding Lysine-acetylated Histone Binding	Protein Tyrosine Phosphatase Activity Protein Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Positive Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Dephosphorylation Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Dephosphorylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AGR2 BARD1 BHLHE40 BRD3 BTBD2 DVL1 FTH1 HAP1 HIST1H2AL HIST2H2BE HIST2H3C HIST3H3 HIST4H4 HNRNPUL1 IRF2 LAMA4 LRIF1 NEFL PAFAH1B3 PCBD1 PSMD11 PTPN13 RBFOX2 RIF1 RPLP1 SERPINB9 TRIM24	21 interactors: APC ARHGAP29 BRD7 CRIP2 CTNNB1 EFNB1 EFNB2 FADD FAS FASLG GHR NFKBIA NGFR NGFRAP1 PDLIM4 PKN2 PLEKHA1 PRKACA RAPGEF6 TRIP6 YWHAZ
Entrez ID		29117	5783
HPRD ID		12531	02602
Ensembl ID		ENSG00000166164	ENSG00000163629
Uniprot IDs		Q9NPI1	Q12923
PDB IDs		2I7K	1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ
Enriched GO Terms of Interacting Partners?		Gene Expression Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Retrograde Axon Cargo Transport Transcription, DNA-templated Telomere Maintenance DNA Methylation On Cytosine DNA Modification Chromatin Silencing At RDNA Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Neuromuscular Process Negative Regulation Of Biosynthetic Process Anterograde Axon Cargo Transport Cellular Response To Estrogen Stimulus Chromatin Silencing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Regulation Of Metabolic Process Axon Cargo Transport Regulation Of Gene Expression, Epigenetic Positive Regulation Of Protein Catabolic Process DNA Methylation Demethylation Mucus Secretion Intracellular Sequestering Of Iron Ion Negative Regulation Of MRNA 3'-end Processing Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Homeostatic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Projection Organization Neuromuscular Process Controlling Balance Convergent Extension Involved In Neural Plate Elongation	Signal Transduction Signaling Cell Communication Apoptotic Process Programmed Cell Death Cell Death Death Cellular Response To Stimulus Regulation Of Signal Transduction Regulation Of Myeloid Cell Differentiation Regulation Of Cell Proliferation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Necroptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Signal Transduction Response To Stimulus Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Cell Adhesion T Cell Differentiation In Thymus Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Junction Assembly Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cell Death Cell-cell Junction Organization Motor Neuron Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Extrinsic Apoptotic Signaling Pathway Zymogen Activation Regulation Of Myeloid Leukocyte Differentiation Necroptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Tagcloud ?		aza clinically cofactor dc demethylating disturbing ectopic endogenous finding glioma gliomas hypermethylation implicated inactivated inactivation intracranial lrrc4 magnetic microrna mir negatively pathological researches resonance restoration silencing transcriptional transplanted verified	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially recurrent respective rps6kb2 seq sequenced smokers somatic sp1 sptan1 stratification targetable ten thousands
Tagcloud (Difference) ?		aza clinically cofactor dc demethylating disturbing ectopic endogenous finding glioma gliomas hypermethylation implicated inactivated inactivation intracranial lrrc4 magnetic microrna mir negatively pathological researches resonance restoration silencing transcriptional transplanted verified	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially recurrent respective rps6kb2 seq sequenced smokers somatic sp1 sptan1 stratification targetable ten thousands
Tagcloud (Intersection) ?