BRD7 and H2AC16

Number of citations of the paper that reports this interaction (PubMedID 12489984)
37

Data Source:
HPRD (in vitro)

		BRD7	H2AC16
Description		bromodomain containing 7	H2A clustered histone 16
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GO Annotations	Cellular Component	Kinetochore Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Matrix RSC-type Complex	Nucleosome Nucleus Chromosome Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Histone Binding Histone H3K14ac Reader Activity Histone Reader Activity	DNA Binding Protein Binding Enzyme Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle Wnt Signaling Pathway Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Heterochromatin Formation
Pathways		Regulation of TP53 Activity through Acetylation Formation of the polybromo-BAF (pBAF) complex	HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines UCH proteinases Ub-specific processing proteases Metalloprotease DUBs HCMV Early Events HCMV Late Events
Drugs
Diseases
GWAS		Allergic sensitization ( 30013184) Epilepsy ( 30531953) Liver enzyme levels (alanine transaminase) ( 24124411) Medication use (thyroid preparations) ( 31015401)
Interacting Genes		30 interacting genes: AGR2 BARD1 BHLHE40 BRD3 BTBD2 DVL1 FTH1 H2AC16 H2BC21 H3-3A H3-4 H3C14 H4C16 HAP1 HNRNPUL1 IRF2 LAMA4 LRIF1 MX1 NEFL PAFAH1B3 PARP1 PCBD1 PLEKHF2 PSMD11 PTPN13 RIF1 RPLP1 SERPINB9 TRIM24	5 interacting genes: BRD7 CRP GADD45A SAP30 TERF2IP
Entrez ID		29117	8332
HPRD ID		12531	09103
Ensembl ID		ENSG00000166164	ENSG00000276903
Uniprot IDs		A0AA34QVS2 Q9NPI1	A4FTV9 P0C0S8
PDB IDs		2I7K 5MQ1 6PPA 6V0Q 6V16 6V17 6V1E 6V1F 6V1H 7VDV 7Y8R	4QYL 5KGF 6R0C 6RNY 6X59 6X5A 6XJD 7BG9 7E8D 7JO9 7JOA 7TAN 7U50 7U51 7U52 7U53 7UV9 8ATF 8AV6 8GUI 8GUJ 8GUK 8OFF 8QZM 8VOB 8VWS 8VWT 8VWU 8VWV 9DWF 9DWG 9DWH 9DWI 9DWJ 9DWK 9DWL 9DWM
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Protein Heterodimerization Activity Structural Constituent Of Chromatin Nucleosome Chromosome Chromosome, Telomeric Region Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly Nucleus Barr Body Telomere Organization Negative Regulation Of Metabolic Process Protein Localization To Chromatin Heterochromatin Formation Subtelomeric Heterochromatin Formation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Nucleoplasm Chromatin Cellular Response To Estrogen Stimulus Extracellular Exosome Retrograde Axonal Transport Protein Binding Protein Localization To Chromosome NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Negative Regulation Of MRNA 3'-end Processing Epigenetic Regulation Of Gene Expression Histone H3K9cr Reader Activity Histone H3K27cr Reader Activity Histone H3K18cr Reader Activity Histone H3K23ac Reader Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neurotrophin Production Positive Regulation Of ERBB Signaling Pathway Chromosome, Telomeric Repeat Region Regulation Of Developmental Process Growth Cone Response To Mineralocorticoid	Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Protein Phosphorylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Phosphorylation Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Double-strand Break Repair Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Developmental Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Choline Binding Regulation Of Developmental Process Negative Regulation Of Peptidyl-serine Phosphorylation Transcription Corepressor Activity Histone H3K14ac Reader Activity Regulation Of Chromosome Organization Regulation Of DNA Repair Protection From Non-homologous End Joining At Telomere Shelterin Complex Negative Regulation Of Macromolecule Metabolic Process Complement Component C1q Complex Binding Positive Regulation Of DNA Metabolic Process Nuclear Telomere Cap Complex Virion Binding Negative Regulation Of Metabolic Process G-rich Strand Telomeric DNA Binding Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Cell Motility Negative Regulation Of Cell Migration Negative Regulation Of RNA Biosynthetic Process Protein Localization To Chromosome, Telomeric Region Telomere Capping Telomere Maintenance In Response To DNA Damage Low-density Lipoprotein Particle Binding Opsonization Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Locomotion Regulation Of RNA Biosynthetic Process RSC-type Complex Positive Regulation Of Superoxide Anion Generation Regulation Of Phosphorylation Negative Regulation Of Lipid Storage
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