DUSP7 and GHR

Number of citations: 0 (PubMedID 12907755)
Data Source: BioGRID (pull down)

		DUSP7	GHR
Name		dual specificity phosphatase 7	growth hormone receptor
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Extracellular Region Extracellular Space Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Receptor Complex Growth Hormone Receptor Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity	Cytokine Receptor Activity Growth Hormone Receptor Activity Protein Binding Lipid Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Phosphatase Binding Cytokine Binding Protein Tyrosine Kinase Activator Activity SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Proline-rich Region Binding Protein Tyrosine Kinase Binding
	Biological Process	MAPK Cascade Signal Transduction Peptidyl-tyrosine Dephosphorylation Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade	Endocytosis Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Response To Gravity Response To Hormone Hormone-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Taurine Metabolic Process Receptor Internalization Response To Food Regulation Of Response To Nutrient Levels Response To Estradiol Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Response To Cytokine Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of MAPK Cascade Response To Peptide Hormone Positive Regulation Of Cell Differentiation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Response To Cycloheximide Insulin-like Growth Factor Receptor Signaling Pathway Response To Glucocorticoid Cartilage Development Involved In Endochondral Bone Morphogenesis Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Growth Hormone Receptor Signaling Pathway Response To Growth Hormone Response To Interleukin-1
Pathways		RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants	Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling
Drugs		None	Somatotropin Pegvisomant Somatrem Somapacitan Lonapegsomatropin
Diseases		None	Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		No GWAS studies recorded	Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Familial squamous cell lung carcinoma ( 29924316 ) Heel bone mineral density ( 30598549 ) Height ( 25429064 28552196 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Iron status biomarkers ( 19084217 ) Menarche (age at onset) ( 25231870 ) Plasma renin activity levels ( 29650764 ) Response to taxane treatment (docetaxel) ( 23006423 ) Systemic lupus erythematosus ( 18204098 )
Novel Interactors		1 novel interactors: CCR1	1 novel interactors: CLCC1
Interacting Genes		10 interacting genes: CFTR CNKSR1 EEF1A1 EGLN3 GHR IL16 MAPK1 MAPK14 MAPK8 SPOP	44 interacting genes: AP2A1 BTRC CISH CUL1 CUL5 DUSP7 ELOB ELOC FBXO31 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 NEDD8 PIK3R1 PIK3R2 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH RBX1 RNF7 SGTA SHC1 SKP1 SOCS1 SOCS2 SOCS3 SRPK2 STAT3 STAT5A STAT5B STUB1 TYK2
Entrez ID		1849	2690
HPRD ID		04125	02971
Ensembl ID		ENSG00000164086	ENSG00000112964
Uniprot IDs		Q16829	A0A087X0H5 A0A087X162 P10912
PDB IDs		4Y2E	1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR 5OEK 5OHD 6I5J 6I5N
GO Terms Enriched among Interactors		MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cytokine-mediated Signaling Pathway Protein Phosphatase Binding Response To Lipid Regulation Of Ossification Positive Regulation Of Neuroinflammatory Response Locomotion Positive Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Chemotaxis Ficolin-1-rich Granule Lumen Positive Regulation Of Cyclase Activity Peptidyl-threonine Phosphorylation Regulation Of Inflammatory Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Inflammatory Response Response To Nutrient Levels Insulin-like Growth Factor Receptor Signaling Pathway Canonical Inflammasome Complex Assembly Regulation Of Chemotaxis Response To Cytokine Regulation Of Neuroinflammatory Response Lipopolysaccharide-mediated Signaling Pathway Response To Peptide Positive Regulation Of Interleukin-12 Production MAPK Cascade Positive Regulation Of Locomotion Response To Epidermal Growth Factor Enzyme-linked Receptor Protein Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding JUN Phosphorylation Homeostatic Process Protein Metabolic Process Cellular Senescence Regulation Of Interleukin-12 Production Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Response To Lipopolysaccharide Cytoplasm Positive Regulation Of Establishment Of Protein Localization Response To Growth Factor Energy Homeostasis Positive Regulation Of Anion Channel Activity Regulation Of Cytokine Production Involved In Inflammatory Response Chemokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 5 Binding	Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Modification Process Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway Via STAT Cytosol Protein Dephosphorylation Growth Hormone Receptor Binding Protein Tyrosine Phosphatase Activity Peptidyl-tyrosine Dephosphorylation Signal Transduction Protein Metabolic Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cell Communication Negative Regulation Of Signaling Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Macromolecule Metabolic Process Cul5-RING Ubiquitin Ligase Complex Dephosphorylation Phosphoprotein Phosphatase Activity Regulation Of Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Protein Ubiquitination Insulin Receptor Binding Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Regulation Of Growth Hormone Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Modification By Small Protein Conjugation Regulation Of Signaling Regulation Of Cell Communication Post-translational Protein Modification SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Regulation Of Cell Adhesion Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cytoplasm