DUSP7

Description		dual specificity phosphatase 7
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity
	Biological Process	MAPK Cascade Signal Transduction Peptidyl-tyrosine Dephosphorylation Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: CCR1
Interacting Genes		10 interacting genes: CFTR CNKSR1 EEF1A1 EGLN3 GHR IL16 MAPK1 MAPK14 MAPK8 SPOP
Entrez ID		1849
HPRD ID		04125
Ensembl ID		ENSG00000164086
Uniprot IDs		Q16829
PDB IDs		4Y2E
Enriched GO Terms of Interacting Partners?		MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cytokine-mediated Signaling Pathway Protein Phosphatase Binding Response To Lipid Regulation Of Ossification Positive Regulation Of Neuroinflammatory Response Locomotion Positive Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Chemotaxis Ficolin-1-rich Granule Lumen Positive Regulation Of Cyclase Activity Peptidyl-threonine Phosphorylation Regulation Of Inflammatory Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Inflammatory Response Response To Nutrient Levels Insulin-like Growth Factor Receptor Signaling Pathway Canonical Inflammasome Complex Assembly Regulation Of Chemotaxis Response To Cytokine Regulation Of Neuroinflammatory Response Lipopolysaccharide-mediated Signaling Pathway Response To Peptide Positive Regulation Of Interleukin-12 Production MAPK Cascade Positive Regulation Of Locomotion Response To Epidermal Growth Factor Enzyme-linked Receptor Protein Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding JUN Phosphorylation Homeostatic Process Protein Metabolic Process Cellular Senescence Regulation Of Interleukin-12 Production Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Response To Lipopolysaccharide Cytoplasm Positive Regulation Of Establishment Of Protein Localization Response To Growth Factor Energy Homeostasis Positive Regulation Of Anion Channel Activity Regulation Of Cytokine Production Involved In Inflammatory Response Chemokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 5 Binding
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