CD9 and ADAM2

Number of citations of the paper that reports this interaction (PubMedID 10518536)
49

Data Source:
HPRD (in vivo)

		CD9	ADAM2
Description		CD9 molecule	ADAM metallopeptidase domain 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Protein-containing Complex Extracellular Exosome Extracellular Vesicle	Plasma Membrane Cell Surface Membrane Protein-containing Complex
	Molecular Function	Integrin Binding Protein Binding	Metalloendopeptidase Activity Integrin Binding Metallopeptidase Activity
	Biological Process	Cell Adhesion Single Fertilization Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Glial Cell Migration Oligodendrocyte Development Myoblast Fusion Involved In Skeletal Muscle Regeneration Cell Differentiation Platelet Activation Paranodal Junction Assembly Receptor Internalization Sperm-egg Recognition Cellular Response To Low-density Lipoprotein Particle Stimulus Negative Regulation Of Platelet Aggregation Regulation Of Macrophage Migration	Proteolysis Cell Adhesion Binding Of Sperm To Zona Pellucida Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Visual Learning Male Gonad Development Gene Expression Positive Regulation Of Gene Expression Adult Behavior
Pathways		Platelet degranulation Acrosome Reaction and Sperm:Oocyte Membrane Binding Uptake and function of diphtheria toxin	Interaction With Cumulus Cells And The Zona Pellucida
Drugs		C31G
Diseases
GWAS		Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Mean platelet volume ( 22139419 27863252 32888494) Paclitaxel-induced neuropathy ( 23776197) Platelet count ( 22139419 26805783)	Restless legs syndrome ( 29029846)
Interacting Genes		25 interacting genes: ADAM2 ADRB2 CD19 CD36 CD38 CD53 CD59 CD63 CD81 CLN8 HBEGF IGSF8 ITGA2 ITGA3 ITGA5 ITGB1 KIT ODF4 PRKCA PTGFRN SERPINH1 SLC22A1 SLC22A2 TSPAN4 VKORC1	2 interacting genes: CD9 CLGN
Entrez ID		928	2515
HPRD ID		00880	03322
Ensembl ID		ENSG00000010278	ENSG00000104755
Uniprot IDs		A0A087WU13 A6NNI4 B4DK09 G8JLH6 P21926	B4DWY7 Q6P2G0 Q99965
PDB IDs		6K4J 6RLO 6RLR 6Z1V 6Z20
Enriched GO Terms of Interacting Partners?		Cell Surface Integrin Binding Membrane Plasma Membrane External Side Of Plasma Membrane System Process Integrin Complex Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Locomotion Learning Or Memory Regulation Of Locomotion Developmental Process Cognition Cell-matrix Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Protein-containing Complex Binding Regulation Of Multicellular Organismal Process Regulation Of System Process Wound Healing, Spreading Of Epidermal Cells Mesodermal Cell Differentiation Integrin Alpha3-beta1 Complex Integrin Alpha5-beta1 Complex Pyrimidine Nucleoside Transmembrane Transporter Activity Vascular Process In Circulatory System Focal Adhesion Import Into Cell Regulation Of Epithelial Cell Migration Neurotransmitter Reuptake Laminin Binding Cell Adhesion Cell-substrate Adhesion Positive Regulation Of Signaling Myoblast Fusion Involved In Skeletal Muscle Regeneration Integrin Alpha2-beta1 Complex Putrescine Transmembrane Transporter Activity Virus Receptor Activity Circulatory System Process Regulation Of Biological Quality Positive Regulation Of Protein Localization To Membrane Myoblast Fusion Cell Adhesion Mediated By Integrin Positive Regulation Of Signal Transduction Receptor Complex Wound Healing, Spreading Of Cells Neurotransmitter Uptake Response To Muscle Activity	Sperm-egg Recognition Cell-cell Recognition Single Fertilization Cell Recognition Fertilization Myoblast Fusion Involved In Skeletal Muscle Regeneration Paranodal Junction Assembly Negative Regulation Of Platelet Aggregation Negative Regulation Of Homotypic Cell-cell Adhesion Myoblast Fusion Oligodendrocyte Development Plasma Membrane Fusion Cellular Response To Low-density Lipoprotein Particle Stimulus Regulation Of Platelet Aggregation Glial Cell Migration Platelet Alpha Granule Membrane Negative Regulation Of Platelet Activation Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Binding Of Sperm To Zona Pellucida Cellular Response To Lipoprotein Particle Stimulus Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Reproductive Process Negative Regulation Of Coagulation Regulation Of Macrophage Migration Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Platelet Activation Protein Folding Chaperone Receptor Internalization Clathrin-coated Endocytic Vesicle Membrane Negative Regulation Of Wound Healing Glial Cell Development Platelet Activation Regulation Of Hemostasis Regulation Of Blood Coagulation Endocytic Vesicle Membrane Extracellular Vesicle ERAD Pathway Unfolded Protein Binding Cell-cell Junction Assembly Plasma Membrane Organization Regulation Of Wound Healing Regulation Of Mononuclear Cell Migration Integrin Binding
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