REEP5 and CD14

Data Source: HiPPIP (Novel)

		REEP5	CD14
Name		receptor accessory protein 5	CD14 molecule
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane Endoplasmic Reticulum Tubular Network	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Secretory Granule Membrane Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome Side Of Membrane
	Molecular Function	Protein Binding	Lipopolysaccharide Binding Opsonin Receptor Activity Lipopolysaccharide Immune Receptor Activity Protein Binding Peptidoglycan Immune Receptor Activity Lipoteichoic Acid Binding Molecular Carrier Activity
	Biological Process	Endoplasmic Reticulum Organization Regulation Of Intracellular Transport Endoplasmic Reticulum Membrane Organization	Positive Regulation Of Cytokine Production Response To Molecule Of Bacterial Origin Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Receptor-mediated Endocytosis Phagocytosis Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Response To Bacterium Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Innate Immune Response Positive Regulation Of Endocytosis Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Diacyl Bacterial Lipopeptide Cellular Response To Triacyl Bacterial Lipopeptide
Pathways		None	ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade Transfer of LPS from LBP carrier to CD14 MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor TLR6:TLR2 Cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Neutrophil degranulation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Respiratory syncytial virus (RSV) attachment and entry Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 RSV-host interactions
Drugs		None	Atibuclimab
Diseases		None	Asthma
GWAS		Attention deficit hyperactivity disorder ( 18839057 ) Daytime nap ( 33568662 ) Reaction time ( 29844566 )	Blood protein levels ( 30072576 ) Refractive error ( 32231278 ) Schizophrenia ( 29483656 ) Serum immune biomarker levels ( 32066700 )
Novel Interactors		9 novel interactors: CD14 CPOX EDC3 GPX3 HBEGF LGR5 PDK4 PDLIM3 TENT4A	1 novel interactors: REEP5
Interacting Genes		13 interacting genes: ABHD4 ARFGAP1 ARFIP2 CHRM5 GTF2H1 NUDT3 PBX3 PITPNC1 RAB5B RABAC1 RGS2 SNX1 VKORC1	14 interacting genes: ARFGAP3 CD55 GJB2 IRAK3 ITGB2 LBP LGALS3BP LTF POLR2J PPP3R2 TLR2 TLR3 TLR4 TNFRSF1B
Entrez ID		7905	929
HPRD ID		15918	01151
Ensembl ID		ENSG00000129625	ENSG00000170458
Uniprot IDs		Q00765	P08571
PDB IDs		Not available	4GLP
GO Terms Enriched among Interactors		None	Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immune Response Regulation Of Immune Response Lipopolysaccharide Binding Lipopolysaccharide-mediated Signaling Pathway Regulation Of Cytokine Production Involved In Immune Response Cellular Response To Lipoteichoic Acid Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Detection Of Molecule Of Bacterial Origin Positive Regulation Of Innate Immune Response Regulation Of Interleukin-6 Production Macrophage Activation Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-12 Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Innate Immune Response-activating Signaling Pathway Defense Response Positive Regulation Of Chemokine Production Cell Surface Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Immune System Process Activation Of Innate Immune Response Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Activation Of Immune Response Regulation Of Interleukin-8 Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of Interleukin-6 Production Regulation Of Immune System Process Regulation Of Chemokine Production Positive Regulation Of Defense Response Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Immune Effector Process Detection Of Biotic Stimulus Positive Regulation Of Cytokine Production Regulation Of Defense Response Negative Regulation Of Osteoclast Differentiation Regulation Of Toll-like Receptor 4 Signaling Pathway Inflammatory Response Myeloid Leukocyte Activation Defense Response To Bacterium Response To External Biotic Stimulus Regulation Of Macrophage Cytokine Production Positive Regulation Of Interferon-beta Production Regulation Of Canonical NF-kappaB Signal Transduction