REEP5 and LGR5

Data Source: HiPPIP (Novel)

		REEP5	LGR5
Name		receptor accessory protein 5	leucine rich repeat containing G protein-coupled receptor 5
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane Endoplasmic Reticulum Tubular Network	Golgi Apparatus Plasma Membrane Membrane Trans-Golgi Network Membrane
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Protein-hormone Receptor Activity
	Biological Process	Endoplasmic Reticulum Organization Regulation Of Intracellular Transport Endoplasmic Reticulum Membrane Organization	Hair Follicle Development Signal Transduction G Protein-coupled Receptor Signaling Pathway Oocyte Differentiation Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Population Proliferation Inner Ear Development Positive Regulation Of Canonical Wnt Signaling Pathway Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis
Pathways		None	Regulation of FZD by ubiquitination
GWAS		Attention deficit hyperactivity disorder ( 18839057 ) Daytime nap ( 33568662 ) Reaction time ( 29844566 )	Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Type 2 diabetes ( 18372903 20581827 22885922 29358691 30297969 32499647 )
Novel Interactors		9 novel interactors: CD14 CPOX EDC3 GPX3 HBEGF LGR5 PDK4 PDLIM3 TENT4A	1 novel interactors: REEP5
Interacting Genes		13 interacting genes: ABHD4 ARFGAP1 ARFIP2 CHRM5 GTF2H1 NUDT3 PBX3 PITPNC1 RAB5B RABAC1 RGS2 SNX1 VKORC1	None recorded
Entrez ID		7905	8549
HPRD ID		15918	05979
Ensembl ID		ENSG00000129625	ENSG00000139292
Uniprot IDs		Q00765	A0A0A8K8C7 O75473
PDB IDs		Not available	4BSR 4BSS 4BST 4BSU 4KNG 4UFR 4UFS
GO Terms Enriched among Interactors		None	Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Membrane Organization Sarcoplasmic Reticulum Membrane Endoplasmic Reticulum Organization Sarcoplasmic Reticulum