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BAG1 and PSMD2
Number of citations of the paper that reports this interaction (PubMedID
33961781
)
97
Data Source:
BioGRID
(two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology)
BAG1
PSMD2
Description
BAG cochaperone 1
proteasome 26S subunit ubiquitin receptor, non-ATPase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Proteasome Accessory Complex
Proteasome Storage Granule
Secretory Granule Lumen
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Molecular Function
Adenyl-nucleotide Exchange Factor Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Protein-folding Chaperone Binding
Protein Binding
Enzyme Regulator Activity
Biological Process
Protein Folding
Apoptotic Process
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Negative Regulation Of Apoptotic Process
Protein Stabilization
Regulation Of Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Regulation of HSF1-mediated heat shock response
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Diseases
GWAS
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Appendicular lean mass (
33097823
)
Birth weight (
31043758
)
Body mass index (
29273807
)
Interacting Genes
31 interacting genes:
AR
ARRB1
BCL2
BCL2L1
CEBPA
ESR1
HBEGF
HSPA1A
HSPA1B
HSPA4
HSPA8
LRRK1
LRRK2
MAPT
MET
NR3C1
OGT
PDGFRB
PPP1R15A
PSMD1
PSMD2
PYGL
RAF1
RARA
RB1
SIAH1
STUB1
TRIM23
TRIM27
UBC
VDR
31 interacting genes:
ADRM1
BAG1
CALM1
CCT2
DSCAM
DSCR9
FAF2
FKBP8
LINC01554
LRIF1
MTNR1A
NDRG1
NUB1
PSMB4
PSMC1
PSMC2
PSMD5
PTN
STEAP1
STUB1
TBC1D3B
TBC1D3G
TNFRSF1A
UBD
UBE3C
UBLCP1
UNC119
USP14
VPS9D1
ZBTB16
ZBTB39
Entrez ID
573
5708
HPRD ID
03292
05870
Ensembl ID
ENSG00000107262
ENSG00000175166
Uniprot IDs
A0A0S2Z3K4
Q99933
Q13200
PDB IDs
1HX1
1WXV
3FZF
3FZH
3FZK
3FZL
3FZM
3LDQ
3M3Z
5AQF
5AQG
5AQH
5AQI
5AQJ
5AQK
5AQL
5AQM
5AQN
5AQO
5AQP
5AQQ
5AQR
5AQS
5AQT
5AQU
5AQV
5GJQ
5GJR
5L4K
5LN3
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7UIH
7UJD
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8CVT
8JRI
8JRT
8JTI
8K0G
8USB
8USC
8USD
9E8G
9E8H
9E8I
9E8J
9E8L
9E8N
9E8O
9E8Q
Enriched GO Terms of Interacting Partners
?
Enzyme Binding
Regulation Of Intracellular Signal Transduction
Regulation Of Protein Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Cell Communication
Regulation Of Signal Transduction
Regulation Of Signaling
Macromolecule Metabolic Process
Cytosol
Ubiquitin Protein Ligase Binding
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Signal Transduction
Response To Hormone
Negative Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Intracellular Signal Transduction
Negative Regulation Of Metabolic Process
Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Nuclear Receptor Activity
Regulation Of Apoptotic Process
C3HC4-type RING Finger Domain Binding
Positive Regulation Of Metabolic Process
Signal Transduction
Response To Steroid Hormone
Identical Protein Binding
Regulation Of Protein Modification Process
ATP-dependent Protein Disaggregase Activity
Cellular Response To Hormone Stimulus
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Regulation Of Cellular Component Organization
G Protein-coupled Receptor Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Mitochondrion
Regulation Of Protein Catabolic Process
Regulation Of Autophagy
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Population Proliferation
Regulation Of Biological Quality
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Microtubule Polymerization
Cellular Response To Steroid Hormone Stimulus
Proteasome Complex
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Proteasome Regulatory Particle, Base Subcomplex
Proteasomal Protein Catabolic Process
Proteasome Accessory Complex
Proteasome Binding
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Macromolecule Catabolic Process
Protein Catabolic Process
Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Proteasome-activating Activity
Positive Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Proteasome Assembly
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Proteolysis
Regulation Of Protein Catabolic Process
Regulation Of Proteolysis
Positive Regulation Of Protein Catabolic Process
Response To Type II Interferon
Regulation Of ERAD Pathway
Presynaptic Cytosol
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Tagcloud (Intersection)
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