BAG1 and HSPA1B

Number of citations of the paper that reports this interaction (PubMedID 11231577)
0

Data Source:
HPRD (two hybrid, in vitro)

		BAG1	HSPA1B
Description		BAG cochaperone 1	heat shock protein family A (Hsp70) member 1B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Inclusion Body Aggresome Nuclear Speck Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-folding Chaperone Binding	Nucleotide Binding Virus Receptor Activity G Protein-coupled Receptor Binding RNA Binding Signaling Receptor Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Protein Folding Chaperone Unfolded Protein Binding C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity ATP-dependent Protein Folding Chaperone
	Biological Process	Protein Folding Apoptotic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Apoptotic Process Protein Stabilization	MRNA Catabolic Process Protein Folding Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Cell Growth Regulation Of Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Cellular Response To Oxidative Stress Cellular Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation ATP Metabolic Process Symbiont Entry Into Host Cell Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Heat Acclimation Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Microtubule Nucleation Negative Regulation Of Inclusion Body Assembly Regulation Of Mitotic Spindle Assembly Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Regulation of HSF1-mediated heat shock response	Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt) Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt)
Drugs		(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Eosinophilic esophagitis ( 29904099) Inflammatory bowel disease ( 28067908) Systemic lupus erythematosus ( 32771030) Ulcerative colitis ( 28067908)
Interacting Genes		31 interacting genes: AR ARRB1 BCL2 BCL2L1 CEBPA ESR1 HBEGF HSPA1A HSPA1B HSPA4 HSPA8 LRRK1 LRRK2 MAPT MET NR3C1 OGT PDGFRB PPP1R15A PSMD1 PSMD2 PYGL RAF1 RARA RB1 SIAH1 STUB1 TRIM23 TRIM27 UBC VDR	25 interacting genes: AIFM1 BAG1 BAG4 BNIP2 CEBPA DNMBP F2RL1 FAF1 FTCD HSPBP1 MYBPC2 NEDD8 PGAM5 SGCG SNCA ST13 STUB1 SUMO4 TGM2 TOMM70 TRIM38 TTN UBQLN2 YWHAB YWHAZ
Entrez ID		573	3304
HPRD ID		03292	06784
Ensembl ID		ENSG00000107262	ENSG00000204388
Uniprot IDs		A0A0S2Z3K4 Q99933	A8K5I0 P0DMV8 P0DMV9
PDB IDs		1HX1 1WXV 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z 5AQF 5AQG 5AQH 5AQI 5AQJ 5AQK 5AQL 5AQM 5AQN 5AQO 5AQP 5AQQ 5AQR 5AQS 5AQT 5AQU 5AQV	1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 3Q49 4IO8 4J8F 4PO2 4WV5 4WV7 5AQW 5AQX 5AQY 5AQZ 5AR0 5BN8 5BN9 5BPL 5BPM 5BPN 5GJJ 5MKR 5MKS 5XI9 5XIR 6FDT 6FHK 6G3R 6G3S 6JPV 6K39 6ZYI 7F4X 7F4Z 7F50 7FGM 7GY4 7GY5 7GY6 7GY7 7GY8 7GY9 7GYA 7GYB 7GYC 7GYD 7GYE 7GYF 7GYG 7GYH 7GYI 7GYJ 7GYK 7GYL 7GYM 7GYN 7GYO 7GYP 7GYQ 7GYR 7GYS 7GYT 7GYU 7GYV 7GYW 7GYX 7KW7 7Q4R
Enriched GO Terms of Interacting Partners?		Enzyme Binding Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Programmed Cell Death Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Macromolecule Metabolic Process Cytosol Ubiquitin Protein Ligase Binding Regulation Of Protein-containing Complex Assembly Negative Regulation Of Signal Transduction Response To Hormone Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Intracellular Signal Transduction Negative Regulation Of Metabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Nuclear Receptor Activity Regulation Of Apoptotic Process C3HC4-type RING Finger Domain Binding Positive Regulation Of Metabolic Process Signal Transduction Response To Steroid Hormone Identical Protein Binding Regulation Of Protein Modification Process ATP-dependent Protein Disaggregase Activity Cellular Response To Hormone Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Regulation Of Cellular Component Organization G Protein-coupled Receptor Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Mitochondrion Regulation Of Protein Catabolic Process Regulation Of Autophagy Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Population Proliferation Regulation Of Biological Quality Negative Regulation Of Biosynthetic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Microtubule Polymerization Cellular Response To Steroid Hormone Stimulus	Ubiquitin Protein Ligase Binding Adenyl-nucleotide Exchange Factor Activity Regulation Of Programmed Cell Death Positive Regulation Of Programmed Cell Death Protein Folding Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Protein Domain Specific Binding Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization Phosphoserine Residue Binding Cytosol Protein Sequestering Activity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Hsp70 Protein Binding Positive Regulation Of Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Protein Stability Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Protein Tag Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase Regulator Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Smooth Muscle Cell Apoptotic Process Response To Alkaloid Positive Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Cell Communication Regulation Of Signaling Dopamine Transport Perinuclear Region Of Cytoplasm Protein-folding Chaperone Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process M Band Regulation Of ERAD Pathway Negative Regulation Of Apoptotic Process Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Establishment Of Protein Localization Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium
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