DHPS and NIF3L1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DHPS	NIF3L1
Gene Name		deoxyhypusine synthase	NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Cytoplasm Mitochondrion
	Molecular Function	Protein Binding Deoxyhypusine Synthase Activity	GTP Cyclohydrolase I Activity Protein Binding GTP Binding Transcription Factor Binding Metal Ion Binding
	Biological Process	Translation Positive Regulation Of Cell Proliferation Peptidyl-lysine Modification To Peptidyl-hypusine Positive Regulation Of T Cell Proliferation Glucose Homeostasis Post-translational Protein Modification Cellular Protein Metabolic Process Deoxyhypusine Biosynthetic Process From Spermidine Protein Homotetramerization	7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Positive Regulation Of Transcription, DNA-templated
Pathways		Post-translational protein modification Hypusine synthesis from eIF5A-lysine Gamma carboxylation, hypusine formation and arylsulfatase activation
Drugs		Nicotinamide-Adenine-Dinucleotide 1-Guanidinium-7-Aminoheptane
Diseases
GWAS
Protein-Protein Interactions		13 interactors: BRCA1 EIF5A EIF5A2 MAPK3 NIF3L1 NUDT18 PTPRH RAB27B REL RPL9 VASH1 WDYHV1 ZNF138	64 interactors: AP5B1 APIP ARPIN BEND7 CCDC102B CCDC85B CDKN2B CDKN2C COIL COPS2 CUTC DCDC2 DCTD DCTPP1 DHPS DMC1 DMRTB1 DUSP23 DYNLT3 EIF5A2 ENOX1 EPHB6 FAM49B FXR2 GNMT GRB2 KCTD17 KRT15 KXD1 LAMTOR3 LMO2 MAGEA11 MAPRE2 MLXIPL NATD1 NME1 NOL3 NUDT14 NUDT21 ORC5 PAICS PCBD1 PRTFDC1 RABAC1 RAD54B RPIA S100A1 SAT1 SNF8 STAT3 STK16 SULT1A2 SULT1A3 SYT17 THOC7 TIFA TRAF2 TRIM21 TRIP13 TSC22D4 VIM YES1 YWHAQ ZBED1
Entrez ID		1725	60491
HPRD ID		02969	10424
Ensembl ID		ENSG00000095059	ENSG00000196290
Uniprot IDs		P49366	Q9GZT8
PDB IDs		1DHS 1RLZ 1ROZ 1RQD
Enriched GO Terms of Interacting Partners?		Translational Frameshifting Positive Regulation Of Translational Termination Positive Regulation Of Translational Elongation Regulation Of Translational Termination Peptidyl-lysine Modification To Peptidyl-hypusine Positive Regulation Of Histone Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Protein Complex Disassembly Translational Elongation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Histone Acetylation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Lymphangiogenesis Positive Regulation Of Histone H4-K20 Methylation DGDP Catabolic Process DADP Catabolic Process Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Apolipoprotein Binding Polyamine Homeostasis GDP Catabolic Process Positive Regulation Of Histone Modification Positive Regulation Of Translation Positive Regulation Of Histone H3-K9 Acetylation 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Cellular Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Apoptotic Process Macromolecule Biosynthetic Process Dihydrobiopterin Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Programmed Cell Death MRNA Transport Cell Death Regulation Of Protein Complex Disassembly Death Regulation Of Histone Modification Multivesicular Body Sorting Pathway Regulation Of Golgi Inheritance Positive Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process RNA Transport Caveolin-mediated Endocytosis Positive Regulation Of Histone Phosphorylation Cellular Response To Indole-3-methanol RNA Localization	Protein Oligomerization Nucleobase-containing Compound Metabolic Process Protein Tetramerization Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Nitrogen Compound Metabolic Process Nucleoside Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Protein Complex Assembly Protein Homotetramerization Purine Nucleoside Metabolic Process Protein Homooligomerization Peptidyl-lysine Modification To Peptidyl-hypusine Polyamine Metabolic Process Polyamine Catabolic Process Ribose Phosphate Metabolic Process Reciprocal Meiotic Recombination Nucleotide Metabolic Process Amine Metabolic Process Ribonucleotide Metabolic Process Biosynthetic Process Cellular Metabolic Process Purine Nucleotide Metabolic Process S-adenosylmethionine Metabolic Process Methionine Metabolic Process Regulation Of Protein Homodimerization Activity Cellular Component Assembly Sulfation Sulfur Compound Metabolic Process Positive Regulation Of T Cell Activation Gene Expression Amine Biosynthetic Process Oocyte Maturation Positive Regulation Of Homotypic Cell-cell Adhesion Transcription, DNA-templated Regulation Of Glycolytic Process Meiosis I Organophosphate Metabolic Process Male Meiosis I Cell Cycle Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cell-cell Adhesion RNA Biosynthetic Process Response To Injury Involved In Regulation Of Muscle Adaptation Deoxyhypusine Biosynthetic Process From Spermidine Glucose Mediated Signaling Pathway Polyamine Homeostasis Response To Brefeldin A
Tagcloud ?		administrations antihypertensive blocker cas ceb curves diastolic dihydropyridine dihydropyridines dogs exerted felodipine hypertensive intravenous lasting lercanidipine nicardipine nitrendipine orally potency rec reference repeated shr spontaneously starting systolic tachyphylaxis
Tagcloud (Difference) ?		administrations antihypertensive blocker cas ceb curves diastolic dihydropyridine dihydropyridines dogs exerted felodipine hypertensive intravenous lasting lercanidipine nicardipine nitrendipine orally potency rec reference repeated shr spontaneously starting systolic tachyphylaxis
Tagcloud (Intersection) ?