DHPS and EIF5A2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		DHPS	EIF5A2
Gene Name		deoxyhypusine synthase	eukaryotic translation initiation factor 5A2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nuclear Pore Endoplasmic Reticulum Membrane Cytosol
	Molecular Function	Protein Binding Deoxyhypusine Synthase Activity	Translation Elongation Factor Activity Protein Binding Ribosome Binding
	Biological Process	Translation Positive Regulation Of Cell Proliferation Peptidyl-lysine Modification To Peptidyl-hypusine Positive Regulation Of T Cell Proliferation Glucose Homeostasis Post-translational Protein Modification Cellular Protein Metabolic Process Deoxyhypusine Biosynthetic Process From Spermidine Protein Homotetramerization	Translational Frameshifting Spermatogenesis Positive Regulation Of Cell Proliferation Peptidyl-lysine Modification To Peptidyl-hypusine Polyamine Homeostasis Protein Transport Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination MRNA Transport
Pathways		Post-translational protein modification Hypusine synthesis from eIF5A-lysine Gamma carboxylation, hypusine formation and arylsulfatase activation	Post-translational protein modification Hypusine synthesis from eIF5A-lysine Gamma carboxylation, hypusine formation and arylsulfatase activation
Drugs		Nicotinamide-Adenine-Dinucleotide 1-Guanidinium-7-Aminoheptane
Diseases
GWAS
Protein-Protein Interactions		13 interactors: BRCA1 EIF5A EIF5A2 MAPK3 NIF3L1 NUDT18 PTPRH RAB27B REL RPL9 VASH1 WDYHV1 ZNF138	7 interactors: CDC23 DHPS NIF3L1 PTBP2 RAB30 REL SDCBP
Entrez ID		1725	56648
HPRD ID		02969	10426
Ensembl ID		ENSG00000095059	ENSG00000163577
Uniprot IDs		P49366	Q9GZV4
PDB IDs		1DHS 1RLZ 1ROZ 1RQD
Enriched GO Terms of Interacting Partners?		Translational Frameshifting Positive Regulation Of Translational Termination Positive Regulation Of Translational Elongation Regulation Of Translational Termination Peptidyl-lysine Modification To Peptidyl-hypusine Positive Regulation Of Histone Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Protein Complex Disassembly Translational Elongation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Histone Acetylation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Lymphangiogenesis Positive Regulation Of Histone H4-K20 Methylation DGDP Catabolic Process DADP Catabolic Process Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Apolipoprotein Binding Polyamine Homeostasis GDP Catabolic Process Positive Regulation Of Histone Modification Positive Regulation Of Translation Positive Regulation Of Histone H3-K9 Acetylation 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Cellular Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Apoptotic Process Macromolecule Biosynthetic Process Dihydrobiopterin Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Programmed Cell Death MRNA Transport Cell Death Regulation Of Protein Complex Disassembly Death Regulation Of Histone Modification Multivesicular Body Sorting Pathway Regulation Of Golgi Inheritance Positive Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process RNA Transport Caveolin-mediated Endocytosis Positive Regulation Of Histone Phosphorylation Cellular Response To Indole-3-methanol RNA Localization
Tagcloud ?		administrations antihypertensive blocker cas ceb curves diastolic dihydropyridine dihydropyridines dogs exerted felodipine hypertensive intravenous lasting lercanidipine nicardipine nitrendipine orally potency rec reference repeated shr spontaneously starting systolic tachyphylaxis	aggressiveness blotting cadherin cck cyclind1 cyclind3 d3 downregulating expressions gastric ges hgc27 immortalized interfering invasion knockdown metallopeptidase mkn28 mta1 mucosal myc qrt silenced sirna suppressing transwell vimentin vimintin
Tagcloud (Difference) ?		administrations antihypertensive blocker cas ceb curves diastolic dihydropyridine dihydropyridines dogs exerted felodipine hypertensive intravenous lasting lercanidipine nicardipine nitrendipine orally potency rec reference repeated shr spontaneously starting systolic tachyphylaxis	aggressiveness blotting cadherin cck cyclind1 cyclind3 d3 downregulating expressions gastric ges hgc27 immortalized interfering invasion knockdown metallopeptidase mkn28 mta1 mucosal myc qrt silenced sirna suppressing transwell vimentin vimintin
Tagcloud (Intersection) ?