DHPS and NUDT18

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DHPS	NUDT18
Gene Name		deoxyhypusine synthase	nudix (nucleoside diphosphate linked moiety X)-type motif 18
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Cytosol
	Molecular Function	Protein Binding Deoxyhypusine Synthase Activity	Magnesium Ion Binding Protein Binding 8-oxo-dGDP Phosphatase Activity 8-oxo-GDP Phosphatase Activity 8-hydroxy-dADP Phosphatase Activity
	Biological Process	Translation Positive Regulation Of Cell Proliferation Peptidyl-lysine Modification To Peptidyl-hypusine Positive Regulation Of T Cell Proliferation Glucose Homeostasis Post-translational Protein Modification Cellular Protein Metabolic Process Deoxyhypusine Biosynthetic Process From Spermidine Protein Homotetramerization	Nucleobase-containing Small Molecule Catabolic Process Small Molecule Metabolic Process DADP Catabolic Process DGDP Catabolic Process GDP Catabolic Process Nucleobase-containing Small Molecule Metabolic Process
Pathways		Post-translational protein modification Hypusine synthesis from eIF5A-lysine Gamma carboxylation, hypusine formation and arylsulfatase activation
Drugs		Nicotinamide-Adenine-Dinucleotide 1-Guanidinium-7-Aminoheptane
Diseases
GWAS
Protein-Protein Interactions		13 interactors: BRCA1 EIF5A EIF5A2 MAPK3 NIF3L1 NUDT18 PTPRH RAB27B REL RPL9 VASH1 WDYHV1 ZNF138	34 interactors: APIP COIL CUTC DCTD DHPS DUT EVI5L GLUL GNMT GSE1 HSD17B14 KCTD13 KCTD17 KHDRBS3 KRT15 KRTAP4-12 KXD1 NADK NAT9 NT5C2 PAICS PCBD1 PSME3 RAB3IL1 RABAC1 RAD54B RWDD1 SDPR TARBP2 TERF2IP TIFA TRAF2 TRIM37 ZBED1
Entrez ID		1725	79873
HPRD ID		02969	07992
Ensembl ID		ENSG00000095059
Uniprot IDs		P49366	Q6ZVK8
PDB IDs		1DHS 1RLZ 1ROZ 1RQD	3GG6
Enriched GO Terms of Interacting Partners?		Translational Frameshifting Positive Regulation Of Translational Termination Positive Regulation Of Translational Elongation Regulation Of Translational Termination Peptidyl-lysine Modification To Peptidyl-hypusine Positive Regulation Of Histone Acetylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Protein Complex Disassembly Translational Elongation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Histone Acetylation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Lymphangiogenesis Positive Regulation Of Histone H4-K20 Methylation DGDP Catabolic Process DADP Catabolic Process Positive Regulation Of Histone H4-K16 Acetylation Negative Regulation Of Apolipoprotein Binding Polyamine Homeostasis GDP Catabolic Process Positive Regulation Of Histone Modification Positive Regulation Of Translation Positive Regulation Of Histone H3-K9 Acetylation 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Cellular Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Apoptotic Process Macromolecule Biosynthetic Process Dihydrobiopterin Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Programmed Cell Death MRNA Transport Cell Death Regulation Of Protein Complex Disassembly Death Regulation Of Histone Modification Multivesicular Body Sorting Pathway Regulation Of Golgi Inheritance Positive Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process RNA Transport Caveolin-mediated Endocytosis Positive Regulation Of Histone Phosphorylation Cellular Response To Indole-3-methanol RNA Localization	Protein Homooligomerization Protein Oligomerization Nucleoside Metabolic Process Protein Tetramerization Nucleobase-containing Small Molecule Metabolic Process Protein Complex Assembly Cellular Nitrogen Compound Metabolic Process Cellular Component Assembly Protein Homotetramerization Nitrogen Compound Metabolic Process Catabolic Process Small Molecule Metabolic Process S-adenosylmethionine Metabolic Process Purine Nucleoside Metabolic Process Methionine Metabolic Process Regulation Of Protein Homodimerization Activity IMP Metabolic Process Alpha-amino Acid Metabolic Process Nucleotide Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide Metabolic Process Polyamine Metabolic Process Cofactor Metabolic Process Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Protein Autoubiquitination Purine Nucleobase Metabolic Process Sulfur Amino Acid Metabolic Process DUMP Biosynthetic Process Deoxyhypusine Biosynthetic Process From Spermidine DUTP Catabolic Process Negative Regulation Of DNA Recombination At Telomere Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Pyrimidine Nucleoside Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Amino Acid Metabolic Process I-kappaB Kinase/NF-kappaB Signaling Glutamine Biosynthetic Process MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Spermidine Catabolic Process L-methionine Biosynthetic Process From S-adenosylmethionine Cellular Modified Amino Acid Metabolic Process Pyrimidine Nucleotide Metabolic Process Pyrimidine Nucleoside Metabolic Process Targeting Of MRNA For Destruction Involved In RNA Interference DUMP Metabolic Process NADP Biosynthetic Process DUTP Metabolic Process Negative Regulation Of Cilium Assembly
Tagcloud ?		administrations antihypertensive blocker cas ceb curves diastolic dihydropyridine dihydropyridines dogs exerted felodipine hypertensive intravenous lasting lercanidipine nicardipine nitrendipine orally potency rec reference repeated shr spontaneously starting systolic tachyphylaxis
Tagcloud (Difference) ?		administrations antihypertensive blocker cas ceb curves diastolic dihydropyridine dihydropyridines dogs exerted felodipine hypertensive intravenous lasting lercanidipine nicardipine nitrendipine orally potency rec reference repeated shr spontaneously starting systolic tachyphylaxis
Tagcloud (Intersection) ?