DEFB1 and MAP4K2

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		DEFB1	MAP4K2
Name		defensin beta 1	mitogen-activated protein kinase kinase kinase kinase 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Membrane Extracellular Exosome Sperm Midpiece Microvesicle	Golgi Membrane Cytoplasm Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Protein Binding CCR6 Chemokine Receptor Binding Identical Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Kinase Activity
	Biological Process	Innate Immune Response In Mucosa Chemotaxis Defense Response Immune Response G Protein-coupled Receptor Signaling Pathway Response To Bacterium Calcium-mediated Signaling Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Symbiont	Immune System Process Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of JNK Cascade
Pathways		Beta defensins Defensins	None
Drugs		None	Fostamatinib
GWAS		Blood pressure ( 24954895 ) Blood protein levels ( 30072576 ) Dental caries (decayed and filled deciduous teeth) ( 31533690 ) Metabolite levels ( 23823483 ) Night sleep phenotypes ( 27126917 ) Plasma kynurenine levels in major depressive disorder ( 29317604 ) Plasma kynurenine to tryptophan ratio in major depressive disorder ( 29317604 ) Psoriatic arthritis ( 26626624 )	Serum uric acid levels ( 32514006 ) Urate levels ( 21768215 )
Novel Interactors		None recorded	1 novel interactors: RELA
Interacting Genes		6 interacting genes: ASPH CCR6 HAP1 MAP4K2 RIF1 VIM	19 interacting genes: DEFB1 GABARAP GABARAPL1 GABARAPL2 HNRNPA2B1 LATS1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A SERPINA4 SNCA SNRNP35 STRN4 TRAF2 XRCC6
Entrez ID		1672	5871
HPRD ID		03634	04408
Ensembl ID		ENSG00000164825	ENSG00000168067
Uniprot IDs		P60022	Q12851
PDB IDs		1E4S 1IJU 1IJV 1KJ5 2NLB 2NLC 2NLD 2NLE 2NLF 2NLG 2NLH 2NLP 2NLQ 2NLS 2PLZ	Not available
GO Terms Enriched among Interactors		Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cation Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Regulation Of Microtubule-based Movement Regulation Of Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Calcium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transporter Activity Isotype Switching To IgA Isotypes DN3 Thymocyte Differentiation Positive Regulation Of Neurotrophin Production Chromosome, Telomeric Repeat Region Positive Regulation Of Calcium Ion Transport Peptidyl-aspartic Acid 3-dioxygenase Activity Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Sequestering Of Calcium Ion Transmembrane Transporter Binding Regulation Of Calcium Ion Transmembrane Transport Thymocyte Migration Brain-derived Neurotrophic Factor Binding Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling DN2 Thymocyte Differentiation Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Monoatomic Ion Transport Hypothalamus Cell Differentiation Positive Regulation Of Store-operated Calcium Channel Activity MAP Kinase Kinase Kinase Kinase Activity Keratin Filament Binding Intracellular Signaling Cassette Regulation Of Calcium Ion Transport Cortical Endoplasmic Reticulum Sperm Plasma Membrane Lens Fiber Cell Development Male Pronucleus Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Regulation Of Intracellular Transport Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Microtubule-based Process Positive Regulation Of Dendritic Cell Chemotaxis Cellular Response To Muramyl Dipeptide Bergmann Glial Cell Differentiation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Non-motile Cilium Assembly Female Pronucleus	Beta-tubulin Binding Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding GABA Receptor Binding Phospholipid Binding Single-stranded Telomeric DNA Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Disassembly Autophagosome Maturation Autophagosome Membrane Mitophagy Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Regulation Of Protein Modification Process Positive Regulation Of JUN Kinase Activity Autophagy Of Mitochondrion Autophagosome Regulation Of Protein Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Regulation Of Protein Metabolic Process Autophagosome Assembly Regulation Of Kinase Activity Cellular Response To Stress Autophagosome Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Autophagy Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Kinase Activity Telomeric DNA Binding Positive Regulation Of Kinase Activity Chromosome Organization Non-canonical NF-kappaB Signal Transduction Protein-containing Complex Binding Positive Regulation Of Protein Modification Process Positive Regulation Of MAP Kinase Activity Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Macroautophagy Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Protein Phosphorylation Chromosome, Telomeric Region Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission