DEFB1 and MAP4K2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		DEFB1	MAP4K2
Gene Name		defensin, beta 1	mitogen-activated protein kinase kinase kinase kinase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extracellular Vesicular Exosome	Golgi Membrane Cytoplasm Basolateral Plasma Membrane
	Molecular Function		Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Small GTPase Regulator Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Innate Immune Response In Mucosa Acute Inflammatory Response Chemotaxis Immune Response G-protein Coupled Receptor Signaling Pathway Response To Bacterium Antibacterial Humoral Response Response To Testosterone Innate Immune Response Defense Response To Gram-positive Bacterium	Protein Phosphorylation Vesicle Targeting Immune Response JNK Cascade Activation Of JUN Kinase Activity Intracellular Signal Transduction Innate Immune Response Positive Regulation Of JNK Cascade
Pathways		Beta defensins Defensins Innate Immune System
Drugs
Diseases
GWAS			Urate levels ( 21768215)
Protein-Protein Interactions		5 interactors: CCR6 HAP1 MAP4K2 RIF1 VIM	13 interactors: DEFB1 HNRNPA2B1 MAP2K4 MAP3K11 MCM3AP-AS1 NACAD POT1 PRDX4 RAB8A SERPINA4 SNRNP35 TRAF2 XRCC6
Entrez ID		1672	5871
HPRD ID		03634	04408
Ensembl ID		ENSG00000164825	ENSG00000168067
Uniprot IDs		P60022	Q12851 Q86VU3
PDB IDs		1E4S 1IJU 1IJV 1KJ5 2NLB 2NLC 2NLD 2NLE 2NLF 2NLG 2NLH 2NLP 2NLQ 2NLS 2PLZ
Enriched GO Terms of Interacting Partners?		Movement Of Cell Or Subcellular Component Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cilium Assembly Establishment Of Vesicle Localization Vesicle Localization Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Bergmann Glial Cell Differentiation Cellular Response To Stimulus Establishment Of Organelle Localization Hypothalamus Cell Differentiation Response To Stress Negative Regulation Of Beta-amyloid Formation Retrograde Axon Cargo Transport Cellular Response To Stress Regulation Of Cell Differentiation Dendritic Cell Chemotaxis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Microtubule-based Movement Organelle Localization Positive Regulation Of Synaptic Transmission, GABAergic Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Smooth Muscle Cell Migration DNA Demethylation Intermediate Filament Organization Regulation Of Cell Projection Organization Lens Fiber Cell Development Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Telomere Maintenance Via Semi-conservative Replication Regulation Of Beta-amyloid Formation Astrocyte Development Regulation Of Cilium Assembly Nuclear DNA Replication Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Amyloid Precursor Protein Catabolic Process Telomere Maintenance Via Recombination Response To Stimulus Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Dendritic Cell Migration Hypothalamus Development Positive Regulation Of Organelle Assembly Positive Regulation Of Cell Cycle G1/S Phase Transition Anterograde Axon Cargo Transport Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening	Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transferase Activity Positive Regulation Of MAP Kinase Activity Activation Of JUN Kinase Activity Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Neuron Death Regulation Of MAP Kinase Activity I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Innate Immune Response Toll-like Receptor 3 Signaling Pathway Positive Regulation Of DNA Replication Telomere Maintenance Positive Regulation Of DNA Strand Elongation Negative Regulation Of Male Germ Cell Proliferation Positive Regulation Of Neuron Death DNA Duplex Unwinding DNA Geometric Change Toll-like Receptor 4 Signaling Pathway JNK Cascade Positive Regulation Of MAPK Cascade Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Intracellular Signal Transduction Cellular Hyperosmotic Salinity Response Regulation Of Male Germ Cell Proliferation Golgi Vesicle Fusion To Target Membrane Telomere Formation Via Telomerase Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Kinase Activity Regulation Of DNA Replication Cellular Response To Sorbitol Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of MAPK Activity Activation Of Innate Immune Response Positive Regulation Of DNA Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To X-ray
Tagcloud ?		20g 44c 52g 5g 87a analysed antimicrobial brazilian constitutively corrections defence defensin gcaaa genital haplotype hbd hpv innate member microorganisms mucosa namely nucleotide papillomavirus polymorphisms snp snps utr viruses
Tagcloud (Difference) ?		20g 44c 52g 5g 87a analysed antimicrobial brazilian constitutively corrections defence defensin gcaaa genital haplotype hbd hpv innate member microorganisms mucosa namely nucleotide papillomavirus polymorphisms snp snps utr viruses
Tagcloud (Intersection) ?