DEFB1

Name	defensin beta 1
Structure
Interactors	6 interactors: ASPH CCR6 HAP1 MAP4K2 RIF1 VIM
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Membrane Extracellular Exosome Sperm Midpiece Microvesicle
	Molecular Function	Protein Binding CCR6 Chemokine Receptor Binding Identical Protein Binding
	Biological Process	Innate Immune Response In Mucosa Chemotaxis Defense Response Immune Response G Protein-coupled Receptor Signaling Pathway Response To Bacterium Calcium-mediated Signaling Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Symbiont
Pathways	Beta defensins Defensins
GWAS	Blood pressure ( 24954895 ) Blood protein levels ( 30072576 ) Dental caries (decayed and filled deciduous teeth) ( 31533690 ) Metabolite levels ( 23823483 ) Night sleep phenotypes ( 27126917 ) Plasma kynurenine levels in major depressive disorder ( 29317604 ) Plasma kynurenine to tryptophan ratio in major depressive disorder ( 29317604 ) Psoriatic arthritis ( 26626624 )
Entrez ID	1672
HPRD ID	03634
Ensembl ID	ENSG00000164825
Uniprot IDs	P60022
PDB IDs	1E4S 1IJU 1IJV 1KJ5 2NLB 2NLC 2NLD 2NLE 2NLF 2NLG 2NLH 2NLP 2NLQ 2NLS 2PLZ
GO Terms Enriched among Interactors ?	Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cation Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Regulation Of Microtubule-based Movement Regulation Of Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Calcium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transporter Activity Isotype Switching To IgA Isotypes DN3 Thymocyte Differentiation Positive Regulation Of Neurotrophin Production Chromosome, Telomeric Repeat Region Positive Regulation Of Calcium Ion Transport Peptidyl-aspartic Acid 3-dioxygenase Activity Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Sequestering Of Calcium Ion Transmembrane Transporter Binding Regulation Of Calcium Ion Transmembrane Transport Thymocyte Migration Brain-derived Neurotrophic Factor Binding Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling DN2 Thymocyte Differentiation Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Monoatomic Ion Transport Hypothalamus Cell Differentiation Positive Regulation Of Store-operated Calcium Channel Activity MAP Kinase Kinase Kinase Kinase Activity Keratin Filament Binding Intracellular Signaling Cassette Regulation Of Calcium Ion Transport Cortical Endoplasmic Reticulum Sperm Plasma Membrane Lens Fiber Cell Development Male Pronucleus Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Regulation Of Intracellular Transport Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Microtubule-based Process Positive Regulation Of Dendritic Cell Chemotaxis Cellular Response To Muramyl Dipeptide Bergmann Glial Cell Differentiation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Non-motile Cilium Assembly Female Pronucleus