DEFB1 and HAP1

Number of citations of the paper that reports this interaction (PubMedID 15383276)
0

Data Source:
HPRD (two hybrid, in vitro)

		DEFB1	HAP1
Description		defensin beta 1	huntingtin associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Membrane Extracellular Exosome Sperm Midpiece Microvesicle	Nucleus Nucleolus Cytoplasm Mitochondrion Lysosome Endosome Early Endosome Autophagosome Endoplasmic Reticulum Centrosome Centriole Cytosol Cytoskeleton Synaptic Vesicle Actin Cytoskeleton Inclusion Body Axon Dendrite Growth Cone Cytoplasmic Vesicle Cell Projection Neuron Projection Dendritic Spine Synapse Presynapse Axon Cytoplasm
	Molecular Function	Protein Binding CCR6 Chemokine Receptor Binding Identical Protein Binding	Signaling Receptor Binding Protein Binding Myosin Binding Transmembrane Transporter Binding Brain-derived Neurotrophic Factor Binding
	Biological Process	Innate Immune Response In Mucosa Chemotaxis Defense Response Immune Response G Protein-coupled Receptor Signaling Pathway Response To Bacterium Calcium-mediated Signaling Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Symbiont	Protein Targeting Exocytosis Autophagy Chemical Synaptic Transmission Brain Development Anterograde Axonal Transport Retrograde Axonal Transport Intracellular Protein Localization Protein Transport Regulation Of Exocytosis Cerebellum Development Hypothalamus Cell Differentiation Neurogenesis Cell Projection Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotrophin Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Distribution Positive Regulation Of Neurogenesis Negative Regulation Of Amyloid-beta Formation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Non-motile Cilium Assembly
Pathways		Beta defensins Defensins
Drugs
Diseases
GWAS		Blood pressure ( 24954895) Blood protein levels ( 30072576) Dental caries (decayed and filled deciduous teeth) ( 31533690) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Plasma kynurenine levels in major depressive disorder ( 29317604) Plasma kynurenine to tryptophan ratio in major depressive disorder ( 29317604) Psoriatic arthritis ( 26626624)	Developmental language disorder (syntactic complexity) ( 27016271) Esophageal cancer (squamous cell) ( 22960999)
Interacting Genes		6 interacting genes: ASPH CCR6 HAP1 MAP4K2 RIF1 VIM	93 interacting genes: AEN ANTKMT APLP1 ATP5MF BARD1 BRD7 C1orf216 C7orf25 C8orf33 CATSPERT CBX8 CCDC13 CDC73 CDK18 CDK5RAP2 CFAP263 COL9A2 CRIP1 DCTN1 DDX49 DEFB1 EIF3E FAM50B FEZ1 GABARAPL2 GADD45G GIT1 GPRASP2 HDAC4 HGS HMOX2 HOXB5 HSPA1A HSPA4 HTT IMMT ING5 KAT5 KAT7 KATNBL1 KBTBD7 KPNA2 LRIF1 LUC7L2 MPP3 MRPS9 MSGN1 NAP1L5 NDUFB9 NEUROD1 NIPSNAP3A NOD2 NOP53 PABPC4 PCM1 PDCD7 PFDN1 PKN1 PPID PPOX PPP1R18 PRPF31 PSMD11 RER1 RHPN1 RIF1 RPS10 RPS25 SCNM1 SNAPIN SRSF4 STX5 TAF1D TBP TIMM17A TNNT1 TNNT3 TOMM20 TSPYL1 UTP3 VIM ZFP1 ZMAT2 ZNF124 ZNF20 ZNF24 ZNF33B ZNF490 ZNF572 ZNF575 ZNF648 ZNF691 ZNF835
Entrez ID		1672	9001
HPRD ID		03634	02972
Ensembl ID		ENSG00000164825	ENSG00000173805
Uniprot IDs		P60022	P54257
PDB IDs		1E4S 1IJU 1IJV 1KJ5 2NLB 2NLC 2NLD 2NLE 2NLF 2NLG 2NLH 2NLP 2NLQ 2NLS 2PLZ
Enriched GO Terms of Interacting Partners?		Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cation Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Regulation Of Microtubule-based Movement Regulation Of Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Calcium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transporter Activity Isotype Switching To IgA Isotypes DN3 Thymocyte Differentiation Positive Regulation Of Neurotrophin Production Chromosome, Telomeric Repeat Region Positive Regulation Of Calcium Ion Transport Peptidyl-aspartic Acid 3-dioxygenase Activity Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Sequestering Of Calcium Ion Transmembrane Transporter Binding Regulation Of Calcium Ion Transmembrane Transport Thymocyte Migration Brain-derived Neurotrophic Factor Binding Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling DN2 Thymocyte Differentiation Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Monoatomic Ion Transport Hypothalamus Cell Differentiation Positive Regulation Of Store-operated Calcium Channel Activity MAP Kinase Kinase Kinase Kinase Activity Keratin Filament Binding Intracellular Signaling Cassette Regulation Of Calcium Ion Transport Cortical Endoplasmic Reticulum Sperm Plasma Membrane Lens Fiber Cell Development Male Pronucleus Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Regulation Of Intracellular Transport Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Microtubule-based Process Positive Regulation Of Dendritic Cell Chemotaxis Cellular Response To Muramyl Dipeptide Bergmann Glial Cell Differentiation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Non-motile Cilium Assembly Female Pronucleus	Nucleus Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Microtubule Nucleation Positive Regulation Of Microtubule Polymerization Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Localization Establishment Of Mitotic Spindle Orientation Mitotic Spindle Pole DNA Replication-dependent Chromatin Disassembly Establishment Of Spindle Orientation Regulation Of Microtubule Nucleation Chromatin Organization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Binding Regulation Of Metabolic Process Establishment Of Spindle Localization Positive Regulation Of Aggrephagy Protein Import Into Mitochondrial Matrix RNA Polymerase Transcription Factor SL1 Complex Histone Acetyltransferase Complex Spindle Localization Regulation Of Microtubule Polymerization Regulation Of Macromolecule Metabolic Process Establishment Of Organelle Localization Centriolar Satellite Male Pronucleus Troponin Complex Protein Acetylation Histone H4K16 Acetyltransferase Activity Gamma-tubulin Binding
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