DEFB1 and CCR6

Number of citations of the paper that reports this interaction (PMID 12149255)
45

Data Source:
HPRD (in vivo)

		DEFB1	CCR6
Gene Name		defensin, beta 1	chemokine (C-C motif) receptor 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function		Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity
	Biological Process	Innate Immune Response In Mucosa Acute Inflammatory Response Chemotaxis Immune Response G-protein Coupled Receptor Signaling Pathway Response To Bacterium Antibacterial Humoral Response Response To Testosterone Innate Immune Response Defense Response To Gram-positive Bacterium	Dendritic Cell Chemotaxis Movement Of Cell Or Subcellular Component Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Innate Immune Response Chemokine-mediated Signaling Pathway
Pathways		Beta defensins Defensins Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Beta defensins Defensins G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Innate Immune System
Drugs
Diseases
GWAS			Crohn's disease ( 18587394 20570966 21102463) Inflammatory bowel disease ( 23128233) Rheumatoid arthritis ( 20453841 20453842) Vitiligo ( 20526339)
Protein-Protein Interactions		5 interactors: CCR6 HAP1 MAP4K2 RIF1 VIM	4 interactors: CCL20 DEFB1 DEFB103B DEFB4A
Entrez ID		1672	1235
HPRD ID		03634	03498
Ensembl ID		ENSG00000164825	ENSG00000112486
Uniprot IDs		P60022	P51684
PDB IDs		1E4S 1IJU 1IJV 1KJ5 2NLB 2NLC 2NLD 2NLE 2NLF 2NLG 2NLH 2NLP 2NLQ 2NLS 2PLZ
Enriched GO Terms of Interacting Partners?		Movement Of Cell Or Subcellular Component Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cilium Assembly Establishment Of Vesicle Localization Vesicle Localization Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Bergmann Glial Cell Differentiation Cellular Response To Stimulus Establishment Of Organelle Localization Hypothalamus Cell Differentiation Response To Stress Negative Regulation Of Beta-amyloid Formation Retrograde Axon Cargo Transport Cellular Response To Stress Regulation Of Cell Differentiation Dendritic Cell Chemotaxis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Microtubule-based Movement Organelle Localization Positive Regulation Of Synaptic Transmission, GABAergic Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Smooth Muscle Cell Migration DNA Demethylation Intermediate Filament Organization Regulation Of Cell Projection Organization Lens Fiber Cell Development Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Telomere Maintenance Via Semi-conservative Replication Regulation Of Beta-amyloid Formation Astrocyte Development Regulation Of Cilium Assembly Nuclear DNA Replication Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Amyloid Precursor Protein Catabolic Process Telomere Maintenance Via Recombination Response To Stimulus Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Dendritic Cell Migration Hypothalamus Development Positive Regulation Of Organelle Assembly Positive Regulation Of Cell Cycle G1/S Phase Transition Anterograde Axon Cargo Transport Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening	Defense Response To Bacterium Response To Bacterium Response To Other Organism Response To Biotic Stimulus Immune Response Defense Response Response To External Stimulus Chemotaxis Immune System Process Innate Immune Response Positive Regulation Of Interleukin-1 Alpha Biosynthetic Process Response To Stress Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria Locomotion Positive Regulation Of Antimicrobial Humoral Response Regulation Of Antimicrobial Humoral Response Positive Regulation Of Interleukin-1 Alpha Production Regulation Of Defense Response To Bacterium Inflammatory Response Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cellular Response To Lipoteichoic Acid Positive Regulation Of Humoral Immune Response Innate Immune Response In Mucosa Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Antibacterial Humoral Response Antimicrobial Humoral Response Regulation Of Lymphocyte Migration Mucosal Immune Response Positive Regulation Of Interleukin-1 Production Response To Testosterone Response To Lipid Positive Regulation Of Immune System Process Regulation Of Humoral Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of Cytokine Biosynthetic Process Acute Inflammatory Response G-protein Coupled Receptor Signaling Pathway Response To Stimulus Positive Regulation Of Leukocyte Migration Regulation Of Immune System Process Regulation Of Cytokine Biosynthetic Process Regulation Of Leukocyte Migration Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Cell Chemotaxis
Tagcloud ?		20g 44c 52g 5g 87a analysed antimicrobial brazilian constitutively corrections defence defensin gcaaa genital haplotype hbd hpv innate member microorganisms mucosa namely nucleotide papillomavirus polymorphisms snp snps utr viruses	confounding conservation corresponded cxcr3 elicit eliminating epitopes hc hcs hyperconserved intragenus latent ltbi mtb mycobacteria naturally nonexposed nontuberculous ntm ntms opposite phenotypically reactivity recognize responded translated true unbiased unexpectedly
Tagcloud (Difference) ?		20g 44c 52g 5g 87a analysed antimicrobial brazilian constitutively corrections defence defensin gcaaa genital haplotype hbd hpv innate member microorganisms mucosa namely nucleotide papillomavirus polymorphisms snp snps utr viruses	confounding conservation corresponded cxcr3 elicit eliminating epitopes hc hcs hyperconserved intragenus latent ltbi mtb mycobacteria naturally nonexposed nontuberculous ntm ntms opposite phenotypically reactivity recognize responded translated true unbiased unexpectedly
Tagcloud (Intersection) ?