HIST1H2AL and SAP30

Number of citations of the paper that reports this interaction (PMID 9651585)
107

Data Source:
HPRD (in vivo)

		HIST1H2AL	SAP30
Gene Name		histone cluster 1, H2al	Sin3A-associated protein, 30kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nucleus Extracellular Vesicular Exosome	Histone Deacetylase Complex Nucleoplasm
	Molecular Function	DNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity	DNA Binding Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Biological_process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression Skeletal Muscle Cell Differentiation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		Chromatin modifying enzymes HDACs deacetylate histones Chromatin organization HATs acetylate histones RMTs methylate histone arginines	NoRC negatively regulates rRNA expression Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: BRD7 CRP GADD45A SAP30 TERF2IP	27 interactors: ARID4A BRMS1 BRMS1L CIR1 HBP1 HDAC1 HDAC2 HIST1H2AL HIST2H2BE HIST3H3 HIST4H4 HTT ID3 ING1 LINC00152 MXD1 NCOR1 NCOR2 PCBD1 RBBP4 RBBP7 RBP1 SAMSN1 SAP30BP SIN3A YY1 ZNF395
Entrez ID		8332	8819
HPRD ID		09103	04540
Ensembl ID		ENSG00000198374	ENSG00000164105
Uniprot IDs		A4FTV9 P0C0S8	O75446
PDB IDs			2KDP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Cellular Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Chromosome Organization Protection From Non-homologous End Joining At Telomere Telomere Capping Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Vasodilation Activation Of MAPKKK Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Superoxide Anion Generation Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Opsonization Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Superoxide Anion Generation Regulation Of Interleukin-8 Secretion Regulation Of P38MAPK Cascade Regulation Of Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Lipid Storage Regulation Of Telomere Maintenance RNA-dependent DNA Replication Positive Regulation Of Histone Acetylation Regulation Of Cellular Component Organization Negative Regulation Of DNA Recombination Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Regulation Of Double-strand Break Repair Nucleobase-containing Compound Metabolic Process Protein Localization To Chromosome Response To Lead Ion Telomere Maintenance Via Telomere Lengthening Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Transcription, DNA-templated Acute-phase Response Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Vasodilation Regulation Of Histone Acetylation Cellular Response To Calcium Ion Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction	Chromosome Organization Negative Regulation Of Gene Expression Chromatin Organization Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Gene Expression Heterocycle Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Organelle Organization Regulation Of Metabolic Process Histone Deacetylation Histone Modification Protein Deacetylation ATP-dependent Chromatin Remodeling Rhythmic Process Histone H3-K9 Modification Transcription From RNA Polymerase II Promoter Circadian Rhythm Chromatin Remodeling CENP-A Containing Nucleosome Assembly Histone Exchange DNA Replication-independent Nucleosome Assembly Homeostatic Process Nucleosome Assembly Cellular Metabolic Process Chromatin Assembly Establishment Of Sertoli Cell Barrier
Tagcloud ?			affects chip deacetylation detecting differential dual encoded enzyme hdac herpes hsv htrp inhibit interact kmb luciferase lysine msin3a promote real regulator repressor reveal significance simplex synergistically transfer viral whose
Tagcloud (Difference) ?			affects chip deacetylation detecting differential dual encoded enzyme hdac herpes hsv htrp inhibit interact kmb luciferase lysine msin3a promote real regulator repressor reveal significance simplex synergistically transfer viral whose
Tagcloud (Intersection) ?