SYP and STARD4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYP	STARD4
Description		synaptophysin	StAR related lipid transfer domain containing 4
Image		No pdb structure
GO Annotations	Cellular Component	Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Presynaptic Membrane Neuron Projection Terminal Bouton Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Excitatory Synapse Schaffer Collateral - CA1 Synapse Presynapse	Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Vesicle
	Molecular Function	Protein Binding Cholesterol Binding SH2 Domain Binding Identical Protein Binding	Protein Binding Lipid Binding Cholesterol Binding Cholesterol Transfer Activity
	Biological Process	Endocytosis Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Maturation Regulation Of Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Membrane Organization Modulation Of Chemical Synaptic Transmission Regulation Of Opioid Receptor Signaling Pathway	Lipid Transport Cholesterol Transport Involved In Cholesterol Storage Intracellular Cholesterol Transport Cholesterol Import Positive Regulation Of Bile Acid Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process
Pathways		Sensory processing of sound by inner hair cells of the cochlea	Pregnenolone biosynthesis
Drugs
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS			Asthma ( 31959851) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Diisocyanate-induced asthma ( 25918132) Menarche (age at onset) ( 25231870) PR interval ( 32439900)
Interacting Genes		41 interacting genes: AP1G1 ARFIP2 CAND2 CD160 DIABLO FARS2 GAB1 GDNF GRB2 HSFX1 HSFX2 JOSD2 LNPK MIEF1 MIEF2 MRM1 MRRF MTERF3 MYG1 NDRG4 PBX3 PITPNC1 PLIN3 PNKP PPIF PTCD1 PTPN9 RBFA SH3GLB1 SIAH1 SIAH2 SMG9 SNX1 SPG21 SSX5 STARD4 THAP4 TUFM VAMP2 WDFY2 WIPI2	6 interacting genes: AGTRAP ARL6IP1 CCHCR1 GDAP1 MTIF3 SYP
Entrez ID		6855	134429
HPRD ID		02435	06133
Ensembl ID		ENSG00000102003	ENSG00000164211
Uniprot IDs		P08247	B0AZS2 Q96DR4
PDB IDs			6L1D 6L1M
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Natural Killer Cell Degranulation Dorsal Spinal Cord Development Mitochondrion Mitochondrial Matrix Mitochondrial Outer Membrane	Regulation Of Opioid Receptor Signaling Pathway Identical Protein Binding Sec61 Translocon Complex Protein Targeting Positive Regulation Of L-glutamate Import Across Plasma Membrane Regulation Of Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Angiotensin Type II Receptor Activity Mitochondrial Translational Initiation Organelle Organization Synaptic Vesicle Maturation Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Membrane Organization Neuron Projection Terminus Regulation Of Synaptic Vesicle Priming Endoplasmic Reticulum Tubular Network Membrane Organization Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Membrane Organization Regulation Of L-glutamate Import Across Plasma Membrane Endoplasmic Reticulum Tubular Network Organization Cotranslational Protein Targeting To Membrane Establishment Of Protein Localization Mitochondrial Fusion Cellular Response To Vitamin D Mitochondrial Fission Angiotensin-activated Signaling Pathway Translation Factor Activity, RNA Binding Ribosomal Small Subunit Binding Positive Regulation Of Amino Acid Transport
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