SYP and GDNF

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYP	GDNF
Description		synaptophysin	glial cell derived neurotrophic factor
Image		No pdb structure
GO Annotations	Cellular Component	Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuromuscular Junction Presynaptic Membrane Neuron Projection Terminal Bouton Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Excitatory Synapse Schaffer Collateral - CA1 Synapse Presynapse	Extracellular Region Extracellular Space Golgi Apparatus
	Molecular Function	Protein Binding Cholesterol Binding SH2 Domain Binding Identical Protein Binding	Signaling Receptor Binding Protein Binding Growth Factor Activity Glial Cell-derived Neurotrophic Factor Receptor Binding Receptor Tyrosine Kinase Binding Protein Homodimerization Activity Chemoattractant Activity Involved In Axon Guidance
	Biological Process	Endocytosis Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Maturation Regulation Of Neuronal Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Synaptic Vesicle Membrane Organization Modulation Of Chemical Synaptic Transmission Regulation Of Opioid Receptor Signaling Pathway	Metanephros Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Neural Crest Cell Migration Organ Induction Postsynaptic Membrane Organization Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Signal Transduction Nervous System Development Peripheral Nervous System Development Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Tissue Development Regulation Of Gene Expression Dorsal Spinal Cord Development Postganglionic Parasympathetic Fiber Development Neuron Differentiation Peristalsis Neuron Projection Development Positive Regulation Of Dopamine Secretion Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Enteric Nervous System Development Sympathetic Nervous System Development Animal Organ Development Embryonic Organ Development Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ureteric Bud Formation Regulation Of Morphogenesis Of A Branching Structure Chemoattraction Of Axon Commissural Neuron Axon Guidance Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Semaphorin-plexin Signaling Pathway
Pathways		Sensory processing of sound by inner hair cells of the cochlea	NCAM1 interactions RAF/MAP kinase cascade RET signaling Formation of the ureteric bud
Drugs			Chondroitin sulfate
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)	Congenital central hypoventilation syndrome (CCHS) Hirschsprung disease (HD)
GWAS			Asthma ( 29273806) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Major depressive disorder ( 20125088)
Interacting Genes		41 interacting genes: AP1G1 ARFIP2 CAND2 CD160 DIABLO FARS2 GAB1 GDNF GRB2 HSFX1 HSFX2 JOSD2 LNPK MIEF1 MIEF2 MRM1 MRRF MTERF3 MYG1 NDRG4 PBX3 PITPNC1 PLIN3 PNKP PPIF PTCD1 PTPN9 RBFA SH3GLB1 SIAH1 SIAH2 SMG9 SNX1 SPG21 SSX5 STARD4 THAP4 TUFM VAMP2 WDFY2 WIPI2	8 interacting genes: AGTRAP GFRA1 GFRA2 MUC1 NCAM1 RET SCAMP5 SYP
Entrez ID		6855	2668
HPRD ID		02435	02906
Ensembl ID		ENSG00000102003	ENSG00000168621
Uniprot IDs		P08247	A0A0S2Z3T2 A0A0S2Z3V2 P39905
PDB IDs			2V5E 3FUB 4UX8 6Q2N
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Natural Killer Cell Degranulation Dorsal Spinal Cord Development Mitochondrion Mitochondrial Matrix Mitochondrial Outer Membrane	Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Activity Side Of Membrane Plasma Membrane Protein Complex Extrinsic Component Of Membrane Receptor Complex Signaling Receptor Activity Regulation Of Cell Adhesion Mediated By Integrin External Side Of Plasma Membrane Plasma Membrane Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Regulation Of Semaphorin-plexin Signaling Pathway Posterior Midgut Development Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Regulation Of Opioid Receptor Signaling Pathway Nervous System Development Neurotrophin Receptor Activity Ureter Maturation Synaptic Vesicle Membrane Angiotensin Type II Receptor Activity GDF15-GFRAL Signaling Pathway Positive Regulation Of Glomerulus Development Kidney Development Enzyme-linked Receptor Protein Signaling Pathway Golgi Membrane Heparan Sulfate Binding Synaptic Vesicle Maturation Endosome Developmental Maturation Lymphocyte Migration Into Lymphoid Organs Axon Guidance Neuron Projection Guidance Positive Regulation Of Kidney Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Synaptic Vesicle Priming Positive Regulation Of Cell Size Enteric Nervous System Development Cytoplasmic Vesicle Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Transcription By Competitive Promoter Binding Commissural Neuron Axon Guidance Regulation Of Short-term Neuronal Synaptic Plasticity
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