HEATR5B and KDM8

Number of citations of the paper that reports this interaction (PubMedID 35538499)
53

Data Source:
BioGRID (pull down, enzymatic study)

		HEATR5B	KDM8
Description		HEAT repeat containing 5B	lysine demethylase 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Clathrin-coated Vesicle Endocytic Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	Protein Binding	P53 Binding Chromatin Binding Endopeptidase Activity Aminopeptidase Activity Protein Binding Peptidase Activity Oxidoreductase Activity Hydrolase Activity Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Peptidyl-arginine 3-dioxygenase Activity
	Biological Process	Endocytosis Intracellular Protein Localization Protein Transport Retrograde Transport, Endosome To Golgi	G2/M Transition Of Mitotic Cell Cycle In Utero Embryonic Development Chromatin Organization Chromatin Remodeling Proteolysis Regulation Of Gene Expression Protein Destabilization Circadian Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Fibroblast Proliferation Rhythmic Process Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Protein hydroxylation
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 28552196) QRS duration ( 30012220) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30578418) Urate levels ( 31578528)	Asthma ( 31619474 31959851) Gut microbiota (bacterial taxa) ( 27723756) Night sleep phenotypes ( 27126917)
Interacting Genes		2 interacting genes: AP1G1 KDM8	8 interacting genes: DDIT4L H3C1 HEATR5B IFT20 ISY1 MEOX2 NUBPL PCYT2
Entrez ID		54497	79831
HPRD ID		11145	07836
Ensembl ID		ENSG00000008869	ENSG00000155666
Uniprot IDs		Q9P2D3	A0A0S2Z5P8 A0A0S2Z5T1 Q8N371
PDB IDs			3UYJ 4AAP 4GAZ 4GJY 4GJZ 4QU1 5FBJ 6AVS 6AX3 6F4M 6F4N 6F4O 6F4P 6F4Q 6F4R 6F4S 6F4T 6I9L 6I9M 6I9N 7DYT 7DYU 7DYV 7DYW 7DYX 7UQ3
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Budding From Endosome Basolateral Protein Secretion Positive Regulation Of Natural Killer Cell Degranulation Peptidyl-arginine 3-dioxygenase Activity Golgi To Lysosome Transport Endosome To Melanosome Transport AP-1 Adaptor Complex Histone H3K36 Demethylase Activity Clathrin Adaptor Activity Intracellular Vesicle Golgi To Vacuole Transport GTP-dependent Protein Binding Melanosome Assembly Platelet Dense Granule Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Clathrin-coated Vesicle Membrane Vesicle Budding From Membrane Synaptic Vesicle Endocytosis Melanosome Organization Membrane Coat Pigment Granule Organization Aminopeptidase Activity Fibroblast Proliferation Presynaptic Endocytosis Kinesin Binding Positive Regulation Of Regulated Secretory Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity G2/M Transition Of Mitotic Cell Cycle Regulation Of Natural Killer Cell Mediated Immunity Cell Cycle G2/M Phase Transition Protein Destabilization Collagen Binding Secretory Granule Organization Clathrin-coated Pit Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Cell Killing Circadian Regulation Of Gene Expression P53 Binding Clathrin-coated Vesicle Dioxygenase Activity Positive Regulation Of Exocytosis Endopeptidase Activity Vesicle-mediated Transport In Synapse Regulation Of Leukocyte Mediated Cytotoxicity Post-Golgi Vesicle-mediated Transport
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