SLN and PLN

Number of citations of the paper that reports this interaction (PubMedID 12692302)
30

Data Source:
HPRD (in vivo)

		SLN	PLN
Description		sarcolipin	phospholamban
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Mitochondrial Membrane Vesicle Protein-containing Complex Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Calcium Ion-transporting ATPase Complex Phospholamban Complex
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Enzyme Regulator Activity ATPase Binding	Enzyme Inhibitor Activity Protein Binding ATPase Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding ATPase Binding Transporter Inhibitor Activity
	Biological Process	Calcium Ion Transport Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Calcium Ion Transport Sarcoplasmic Reticulum Calcium Ion Transport Negative Regulation Of Calcium Ion Import Positive Regulation Of Cold-induced Thermogenesis Regulation Of Relaxation Of Muscle Positive Regulation Of Protein Depolymerization Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum	Acrosome Assembly Regulation Of The Force Of Heart Contraction Calcium Ion Transport Intracellular Calcium Ion Homeostasis Notch Signaling Pathway Spermatogenesis Blood Circulation Regulation Of Heart Contraction Visual Learning Response To Zinc Ion Negative Regulation Of Heart Rate Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Insulin Response To Testosterone Locomotor Rhythm Negative Regulation Of Heart Contraction Muscle Cell Cellular Homeostasis Cardiac Muscle Tissue Development Circadian Sleep/wake Cycle, Sleep Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Relaxation Of Cardiac Muscle Regulation Of Cardiac Muscle Cell Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of The Force Of Heart Contraction By Cardiac Conduction Regulation Of Calcium Ion Import Negative Regulation Of Calcium Ion Import Regulation Of Relaxation Of Muscle Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways		Ion homeostasis Ion transport by P-type ATPases	Ion homeostasis Ion transport by P-type ATPases
Drugs
Diseases
GWAS			Atrial fibrillation ( 28416818 30061737) Cardiac structure and function ( 19584346) Hypertrophic cardiomyopathy ( 33495597) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) QRS complex (Sokolow-Lyon) ( 27659466) QRS duration ( 27577874 27659466) QT interval ( 19305408 19305409 19587794 23166209 24952745 29874175) Resting heart rate ( 27798624)
Interacting Genes		7 interacting genes: ATP2A1 KASH5 LMNA PLN PTPN11 SYNE4 TMEM79	68 interacting genes: AQP6 ARL13B ARLN ASGR2 ATP2A1 ATP2A2 ATP6V0E1 BCL2L13 BIK CD53 CLDN7 CLEC2D CPLX4 CREB3 CREB3L1 DMPK DVL3 EDA ELN ELOVL4 ERGIC3 FAM209A FKBP8 FNDC9 GJA8 GPR152 GPR37L1 GPX8 HIBADH HSD17B13 KIR2DL3 LDLRAD1 LSMEM2 MFF MGST2 MGST3 MS4A7 MTIF3 MUC1 PLPPR1 PPP1R3A PRKACA RTN3 S100A1 SAR1A SDC3 SIT1 SLC14A2 SLC30A8 SLC34A2 SLC35H1 SLC39A2 SLC61A1 SLN SPACA1 SPAG4 STX1A STX2 TMEM106C TMEM179B TMEM205 TMEM31 TMEM45A TMEM45B TMEM52B TMEM79 TMEM86B TMPRSS2
Entrez ID		6588	5350
HPRD ID		03729	01395
Ensembl ID		ENSG00000170290	ENSG00000198523
Uniprot IDs		A0A158RFT9 O00631	P26678 Q5R352
PDB IDs		1JDM	1PLP 1ZLL 2HYN 6Y40 7E0Z 7E11 7E12
Enriched GO Terms of Interacting Partners?		Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Meiotic Nuclear Membrane Microtubule Tethering Complex Relaxation Of Muscle Regulation Of Cardiac Muscle Cell Contraction Regulation Of ATP-dependent Activity Regulation Of System Process Nuclear Envelope Nuclear Outer Membrane Sarcoplasmic Reticulum Membrane Regulation Of Muscle System Process Regulation Of Intracellular Transport Maintenance Of Mitochondrion Location Calcium-dependent ATPase Activity Sarcoplasmic Reticulum Regulation Of Transmembrane Transporter Activity Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Relaxation Of Skeletal Muscle H Zone Regulation Of Cardiac Muscle Contraction Positive Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction Regulation Of Striated Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transporter Activity DNA Double-strand Break Attachment To Nuclear Envelope Chromosome Localization Structural Constituent Of Nuclear Lamina Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Circadian Sleep/wake Cycle, Sleep Phospholamban Complex Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Intestinal Epithelial Cell Migration Meiotic Spindle Pole Organelle Localization Developmental Process Negative Regulation Of Multicellular Organismal Process Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Cellular Localization Negative Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Cerebellar Cortex Formation Cuticle Development Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Circadian Sleep/wake Cycle Process Negative Regulation Of Glucocorticoid Secretion Anterior Head Development	Membrane Endoplasmic Reticulum Membrane Protein Binding Sarcoplasmic Reticulum Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Sarcoplasmic Reticulum Membrane Endoplasmic Reticulum Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Import Into Sarcoplasmic Reticulum Glutathione Peroxidase Activity Leukotriene-C4 Synthase Activity Regulation Of Cardiac Conduction Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity
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