AP2A1 and MYO6

Number of citations of the paper that reports this interaction (PMID 11447109)
68

Data Source:
BioGRID (pull down)

		AP2A1	MYO6
Gene Name		adaptor-related protein complex 2, alpha 1 subunit	myosin VI
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Ruffle Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Microvillus Coated Pit Cell Cortex Membrane Cytoplasmic Membrane-bounded Vesicle Unconventional Myosin Complex DNA-directed RNA Polymerase II, Holoenzyme Endocytic Vesicle Axon Clathrin-coated Vesicle Membrane Filamentous Actin Nuclear Membrane Ruffle Membrane Neuronal Cell Body Apical Part Of Cell Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity	Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ADP Binding Actin Filament Binding Minus-end Directed Microfilament Motor Activity
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process	Protein Targeting Intracellular Protein Transport Endocytosis Synaptic Transmission Synapse Assembly Sensory Perception Of Sound Locomotory Behavior Metabolic Process Glutamate Secretion Dendrite Development Actin Filament-based Movement DNA Damage Response, Signal Transduction By P53 Class Mediator Inner Ear Morphogenesis Auditory Receptor Cell Differentiation Response To Drug Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Synaptic Plasticity Regulation Of Secretion Membrane Organization Cellular Response To Electrical Stimulus
Pathways		Trafficking of GluR2-containing AMPA receptors Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Trafficking of AMPA receptors beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses	Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Hypertension ( 21626137)
Protein-Protein Interactions		27 interactors: AMPH AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 EHD1 EPN1 EPS15 GHR HIP1 MYO6 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1	17 interactors: ACTA1 AP2A1 APC CALCOCO2 CALM2 CDC42 DAB1 DAB2 DLG1 GIPC1 OPTN PAK1 PAK3 RNF11 TAX1BP1 TOM1 TOM1L2
Entrez ID		160	4646
HPRD ID		03016	02985
Ensembl ID		ENSG00000196961	ENSG00000196586
Uniprot IDs		O95782	Q9UM54
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Clathrin Coat Assembly Establishment Of Localization In Cell Synaptic Vesicle Transport Cellular Localization Regulation Of Vesicle-mediated Transport Membrane Budding Transport Cellular Protein Complex Assembly Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Synaptic Transmission Signaling Membrane Organization Cell Communication Cellular Macromolecular Complex Assembly Cell-cell Signaling Establishment Of Organelle Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Regulation Of Endocytosis Regulation Of ERBB Signaling Pathway Regulation Of Cellular Component Organization Organelle Localization Neuron Development Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Protein Complex Assembly Positive Regulation Of Transport Secretion By Cell Cellular Component Assembly Receptor Internalization Neuron Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Negative Regulation Of ERBB Signaling Pathway Generation Of Neurons Exocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Vesicle Priming ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurogenesis Secretion Neuron Projection Morphogenesis Response To Stimulus Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway	Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Regulation Of Cell Adhesion Movement Of Cell Or Subcellular Component Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Cell Morphogenesis Involved In Differentiation Regulation Of Signal Transduction Immune System Process Positive Regulation Of Protein Kinase Activity Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Division Neuron Projection Development Positive Regulation Of Protein Metabolic Process Locomotion Regulation Of Signaling Positive Regulation Of Phosphorylation Cellular Localization Cell Development Axonogenesis Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Cellular Protein Localization Protein Localization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Development Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Neuron Projection Morphogenesis Cell Morphogenesis Positive Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Axon Guidance Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Response To Stimulus Cell Projection Organization Negative Regulation Of Signaling Regulation Of Cytokinesis Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Response To External Stimulus Cell Projection Morphogenesis Regulation Of Immune System Process Regulation Of Cell Cycle Process
Tagcloud ?			109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt myb1 neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 tom1 ubbd ubbddelta weakened
Tagcloud (Difference) ?			109qmhtt 410delta 520delta 81qnmhtt autophagosome autophagosomes colocalize d474n e478g e50k htt huntingtin ibs interfered k63 mhtt myb1 neuro2a optineurin optn polyubiquitin polyubiquitinated puncta r6 tardbpnd251 tom1 ubbd ubbddelta weakened
Tagcloud (Intersection) ?