DPYSL2 and LUC7L

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		DPYSL2	LUC7L
Description		dihydropyrimidinase like 2	LUC7 like
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Extracellular Exosome Mitotic Spindle Plasma Membrane Bounded Cell Projection	U1 SnRNP U2-type Prespliceosome
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Identical Protein Binding	MRNA Binding Protein Binding Identical Protein Binding RS Domain Binding
	Biological Process	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Endocytosis Cytoskeleton Organization Signal Transduction Nervous System Development Cell Differentiation	MRNA Splice Site Recognition Negative Regulation Of Striated Muscle Tissue Development
Pathways		CRMPs in Sema3A signaling Recycling pathway of L1
Drugs		Artenimol
Diseases
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (1df test) ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)	Heel bone mineral density ( 30598549) Hemoglobin concentration ( 27863252) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 28453575 27863252 20139978 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		18 interacting genes: AP2A1 CDC42 CRMP1 DISC1 DPYSL5 DSCAM DSCR9 EXOSC7 GORASP2 GSK3B LEF1 LUC7L NUMB PLD2 ROCK1 TNIK TUBB UBE2I	20 interacting genes: ANTKMT APPL1 CALM1 CHERP CLK2 CTNNBL1 DPYSL2 EIF4ENIF1 FBXO25 GADD45G PRDX1 PRMT5 SRPK2 SRRM4 SRSF1 SRSF6 SRSF7 SRSF8 TCERG1 TSC1
Entrez ID		1808	55692
HPRD ID		03914	08476
Ensembl ID		ENSG00000092964	ENSG00000007392
Uniprot IDs		A0A1C7CYX9 Q16555 Q59GB4	A8MYV2 Q1W6G4 Q9NQ29
PDB IDs		2GSE 2VM8 5LXX 5MKV 5MLE 5X1A 5X1C 5X1D 5YZ5 5YZA 5YZB 6JV9 6JVB 7X68 8DNM
Enriched GO Terms of Interacting Partners?		Glutamatergic Synapse Nervous System Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Projection Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Projection Organization Positive Regulation Of Cell-matrix Adhesion System Development Cell Projection Organization Positive Regulation Of Cell Projection Organization Regulation Of Cell Development Regulation Of Neurogenesis Regulation Of Cell-substrate Adhesion Presynapse Cytoskeleton Organization Regulation Of Nervous System Development Wnt Signaling Pathway Neuron Projection Morphogenesis Regulation Of Cell-matrix Adhesion Cell Projection Morphogenesis Dihydropyrimidinase Activity Regulation Of Synapse Organization Regulation Of Cellular Component Organization Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Plasma Membrane Bounded Cell Projection Organization Pyrimidine Nucleobase Catabolic Process Positive Regulation Of Locomotion Regulation Of Dendrite Morphogenesis Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Muscle Organ Development Negative Regulation Of Muscle Tissue Development Regulation Of Axon Extension Epithelial To Mesenchymal Transition Regulation Of Locomotion Apical Part Of Cell Cytoskeleton Cellular Component Assembly Regulation Of Developmental Process Dendrite Positive Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Dendrite Development Regulation Of Cell Differentiation Canonical Wnt Signaling Pathway Organelle Organization Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Beta-catenin Binding Pyrimidine Nucleobase Metabolic Process	Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Splicing Nuclear Speck Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Processing MRNA Metabolic Process MRNA Binding RNA Binding Negative Regulation Of MRNA Metabolic Process RNA Metabolic Process Nucleus Protein-RNA Complex Assembly Protein Kinase B Binding Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Liver Regeneration Macromolecule Metabolic Process MRNA Splice Site Recognition Protein Methylation Regulation Of Cell Cycle Positive Regulation Of RNA Splicing Protein Localization To Nucleus Memory T Cell Differentiation Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Animal Organ Regeneration Nucleoplasm Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Protein Localization To P-body Peptidyl-arginine N-methylation Positive Regulation Of Macropinocytosis Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Stabilization Identical Protein Binding
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