DPYSL2 and PLD2

Number of citations of the paper that reports this interaction (PMID 11741937)
7

Data Source:
HPRD (in vivo, in vitro)

		DPYSL2	PLD2
Gene Name		dihydropyrimidinase-like 2	phospholipase D2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol Microtubule Membrane Dendrite Growth Cone Neuronal Cell Body Terminal Bouton Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane Plasma Membrane Brush Border Membrane
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Protein Kinase Binding	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity
	Biological Process	Response To Amphetamine Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Endocytosis Cytoskeleton Organization Signal Transduction Nervous System Development Axon Guidance Regulation Of Neuron Projection Development Positive Regulation Of Glutamate Secretion Spinal Cord Development Olfactory Bulb Development Response To Cocaine Response To Drug Synaptic Vesicle Transport	G-protein Coupled Receptor Internalization Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylglycerol Biosynthetic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Lipid Catabolic Process Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Glycerophospholipid Biosynthetic Process
Pathways		Axon guidance Semaphorin interactions L1CAM interactions CRMPs in Sema3A signaling Recycling pathway of L1	Synthesis of PA Metabolism of lipids and lipoproteins Synthesis of PG Role of phospholipids in phagocytosis Phospholipid metabolism Glycerophospholipid biosynthesis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System
Drugs
Diseases
GWAS			Sphingolipid levels ( 22359512)
Protein-Protein Interactions		14 interactors: AP2A1 CRMP1 DISC1 DPYSL3 DPYSL4 DPYSL5 GORASP2 GSK3B LEF1 NUMB PLD2 ROCK1 TNIK TUBB	26 interactors: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A LCK MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1
Entrez ID		1808	5338
HPRD ID		03914	03857
Ensembl ID		ENSG00000092964	ENSG00000129219
Uniprot IDs		Q16555 Q59GB4	I3L2C9 O14939
PDB IDs		2GSE 2VM8
Enriched GO Terms of Interacting Partners?		Pyrimidine Nucleobase Catabolic Process Chemotaxis Axon Guidance Movement Of Cell Or Subcellular Component Generation Of Neurons Cell Morphogenesis Involved In Differentiation Neurogenesis Locomotion Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Neuron Differentiation Nervous System Development Cell Projection Organization Neuron Projection Development Pyrimidine Nucleobase Metabolic Process Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Development Response To External Stimulus Cell Differentiation System Development Anatomical Structure Morphogenesis Multicellular Organismal Development Regulation Of Cell Development Anatomical Structure Development Positive Regulation Of Cell Development Response To Stimulus Regulation Of Cell Differentiation Wnt Signaling Pathway Developmental Process Telencephalon Development Canonical Wnt Signaling Pathway Cytoskeleton Organization Forebrain Neuroblast Division Neural Precursor Cell Proliferation Regulation Of Neurogenesis Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Regulation Of Epithelial Cell Differentiation Positive Regulation Of Neurogenesis Positive Regulation Of Cell Differentiation Forebrain Development Somatic Stem Cell Division Cell Surface Receptor Signaling Pathway Organelle Organization Regulation Of Cell Projection Organization	Platelet Activation Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Epidermal Growth Factor Receptor Signaling Pathway Response To Wounding ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Stress Response To Organic Substance Endocytosis Cell Activation Vesicle-mediated Transport Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To External Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process T Cell Costimulation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Response To Organonitrogen Compound Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Protein Autophosphorylation Immune Response Regulation Of Cellular Localization Regulation Of Cell-cell Adhesion Defense Response Regulation Of Intracellular Signal Transduction Response To Growth Factor Immune System Process Regulation Of Signaling Positive Regulation Of Phosphorylation Negative Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Transport Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Cellular Response To Organonitrogen Compound Regulation Of Cell Activation
Tagcloud ?		24months 2de 8months astrocytic avenues coactosin creatine diamond dihydropyrimidinase dynamin e693delta glutamic glyoxalase illuminate isocitrate littermates oligomers pea phosphoprotein phosphoproteins possessed presumed profilin ruby sh3 sypro transgenic triphosphatase vacuolar	1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld1 responsive se secretion tumorigenesis u87 utilize vegf
Tagcloud (Difference) ?		24months 2de 8months astrocytic avenues coactosin creatine diamond dihydropyrimidinase dynamin e693delta glutamic glyoxalase illuminate isocitrate littermates oligomers pea phosphoprotein phosphoproteins possessed presumed profilin ruby sh3 sypro transgenic triphosphatase vacuolar	1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld1 responsive se secretion tumorigenesis u87 utilize vegf
Tagcloud (Intersection) ?