CAV1 and NOS2

Number of citations of the paper that reports this interaction (PMID 11114180)
20

Data Source:
BioGRID (biochemical, pull down)
HPRD (in vitro)

		CAV1	NOS2
Gene Name		caveolin 1, caveolae protein, 22kDa	nitric oxide synthase 2, inducible
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Acrosomal Membrane Intracellular Endosome Endoplasmic Reticulum Lipid Particle Plasma Membrane Integral Component Of Plasma Membrane Caveola Focal Adhesion Cilium Cell Cortex Basolateral Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Protein Complex Membrane Raft Perinuclear Region Of Cytoplasm	Intracellular Nucleus Cytoplasm Peroxisome Cytosol Cortical Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Binding Patched Binding Structural Molecule Activity Protein Binding Cholesterol Binding Peptidase Activator Activity Enzyme Binding Protein Kinase Binding Protein Complex Scaffold Identical Protein Binding Ion Channel Binding Nitric-oxide Synthase Binding Inward Rectifier Potassium Channel Inhibitor Activity	NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Receptor Binding Iron Ion Binding Protein Binding Calmodulin Binding FMN Binding Heme Binding Tetrahydrobiopterin Binding Arginine Binding Protein Homodimerization Activity Flavin Adenine Dinucleotide Binding NADP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Inactivation Of MAPK Activity Angiogenesis Vasculogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Response To Ischemia Regulation Of The Force Of Heart Contraction By Chemical Signal Triglyceride Metabolic Process Calcium Ion Transport Cellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Skeletal Muscle Tissue Development Lactation Blood Coagulation Protein Localization Cellular Response To Starvation Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Peptidase Activity Viral Process Vesicle Organization Regulation Of Fatty Acid Metabolic Process Lipid Storage Regulation Of Blood Coagulation Cholesterol Transport Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Maintenance Of Protein Location In Cell Response To Progesterone Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Nitric Oxide Homeostasis Vasoconstriction Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Cholesterol Homeostasis Negative Regulation Of MAPK Cascade Response To Estrogen Small Molecule Metabolic Process Protein Localization To Plasma Membrane Raft Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Vasoconstriction Nitric Oxide Metabolic Process Negative Regulation Of JAK-STAT Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Pinocytosis Positive Regulation Of Metalloenzyme Activity Leukocyte Migration Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Nitric-oxide Synthase Activity Protein Homooligomerization Cytosolic Calcium Ion Homeostasis Response To Calcium Ion Membrane Depolarization Regulation Of Peptidase Activity Calcium Ion Homeostasis Mammary Gland Involution Negative Regulation Of Protein Tyrosine Kinase Activity Caveola Assembly Cellular Response To Hyperoxia Caveolin-mediated Endocytosis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Membrane Repolarization During Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Inward Rectifier Potassium Channel Activity Protein Localization To Basolateral Plasma Membrane Receptor Internalization Involved In Canonical Wnt Signaling Pathway Negative Regulation Of Anoikis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Response To Hypoxia Positive Regulation Of Leukocyte Mediated Cytotoxicity Innate Immune Response In Mucosa Arginine Catabolic Process Superoxide Metabolic Process Nitric Oxide Biosynthetic Process Inflammatory Response Nitric Oxide Mediated Signal Transduction Blood Coagulation Circadian Rhythm Response To Bacterium Negative Regulation Of Gene Expression Peptidyl-cysteine S-nitrosylation Positive Regulation Of Guanylate Cyclase Activity Regulation Of Cell Proliferation Negative Regulation Of Protein Catabolic Process Defense Response To Bacterium Regulation Of Cellular Respiration Negative Regulation Of Blood Pressure Positive Regulation Of Vasodilation Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Interaction With Host Positive Regulation Of Killing Of Cells Of Other Organism Oxidation-reduction Process Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Phagosome Maturation
Pathways		Metabolism of lipids and lipoproteins misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Lipid digestion, mobilization, and transport Signaling by Wnt Basigin interactions VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall eNOS activation disassembly of the destruction complex and recruitment of AXIN to the membrane Metabolism of nitric oxide Signaling by VEGF TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis NOSTRIN mediated eNOS trafficking VEGFR2 mediated vascular permeability XAV939 inhibits tankyrase, stabilizing AXIN eNOS activation and regulation Signaling by WNT in cancer	Platelet homeostasis Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Nitric oxide stimulates guanylate cyclase
Drugs			L-Arginine L-Citrulline Miconazole Dexamethasone N,N-dimethylarginine 4r-Fluoro-N6-Ethanimidoyl-L-Lysine 3-Bromo-7-Nitroindazole N-(3-(Aminomethyl)Benzyl)Acetamidine 7-Nitroindazole Ethylisothiourea Thiocoumarin Aminoguanidine S-Ethylisothiourea N-Omega-Propyl-L-Arginine (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin Heme 6-Nitroindazole N-Omega-Hydroxy-L-Arginine 7,8-Dihydro-L-Biopterin N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine L-Thiocitrulline 7,8-Dihydrobiopterin 5-Nitroindazole 5-(4\'-AMINO-1\'-ETHYL-5\',8\'-DIFLUORO-1\'H-SPIRO[PIPERIDINE-4,2\'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE 1-(6-CYANO-3-PYRIDYLCARBONYL)-5\',8\'-DIFLUOROSPIRO[PIPERIDINE-4,2\'(1\'H)-QUINAZOLINE]-4\'-AMINE 4-(1H-IMIDAZOL-1-YL)PHENOL 1-[4-(AMINOMETHYL)BENZOYL]-5\'-FLUORO-1\'H-SPIRO[PIPERIDINE-4,2\'-QUINAZOLIN]-4\'-AMINE Triflusal
Diseases
GWAS		Atrial fibrillation ( 22544366) Electrocardiographic traits ( 20062063) Glaucoma (primary open-angle) ( 20835238) PR interval ( 20062060 23139255)	Crohn's disease ( 23128233) Psoriasis ( 20953189)
Protein-Protein Interactions		81 interactors: ABCB1 ABL1 ADRBK1 AKAP1 APP AR BMX BSG BST1 BTK CAV2 CD40 CSK CSNK2A1 CSNK2A2 DAG1 DNM1 EDNRB EGFR ERBB2 ESR1 FLNA FLOT2 FYN GJA1 GJA3 GJB2 GNAI2 GRB7 GRK1 GRK5 HRAS HTR1F IGF1R IGFBP3 ILK INSR IRS1 KDR LATS1 LRP1 MALL MAPK1 MAPK3 MMP14 NEU3 NGFR NOS2 NOS3 NTRK1 PDGFRA PDGFRB PLD1 PLD2 PPP1CA PPP2CA PRNP PTEN PTGS2 PTPN1 PTPN11 PTPN6 PTPRF RAC1 RCVRN RHOA RHOC S1PR1 SCP2 SNCA SOS1 SRC STOML3 STRN STRN4 TGFBR1 TNFRSF1B TRAF2 TRAF6 TRPC1 VCP	11 interactors: ACTB ACTN4 CAV1 PEX5 RAC1 RAC2 SLC9A3R1 SPSB1 SPSB2 SPSB4 SRC
Entrez ID		857	4843
HPRD ID		03028	01225
Ensembl ID		ENSG00000105974	ENSG00000007171
Uniprot IDs		A9XTE5 Q03135 Q2TNI1 Q59E85 Q7Z4F3	P35228
PDB IDs			1NSI 2LL6 2NSI 3E7G 3EJ8 3HR4 4NOS
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Signal Transduction Locomotion Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Response To External Stimulus Response To Stimulus Response To Organic Substance Cellular Response To Stimulus Regulation Of Cell Proliferation Regulation Of Phosphorylation Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Wound Healing Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Response To Wounding Positive Regulation Of Phosphorylation Cell Development Regulation Of Catalytic Activity Developmental Process Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Kinase Activity Regulation Of Body Fluid Levels Chemotaxis Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Catalytic Activity Blood Coagulation Anatomical Structure Development Hemostasis Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Tissue Development Intracellular Signal Transduction Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway System Development Neurotrophin Signaling Pathway Neuron Projection Morphogenesis Response To Stress Cell Morphogenesis Involved In Neuron Differentiation	Blood Coagulation Hemostasis Platelet Activation Regulation Of Body Fluid Levels Vascular Endothelial Growth Factor Receptor Signaling Pathway Wound Healing Tissue Remodeling Cellular Component Assembly Regulation Of Cellular Component Movement Response To Wounding Bone Resorption Tissue Homeostasis Regulation Of Endocytosis Cell-cell Junction Organization Bone Remodeling Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Protein Homooligomerization Signal Transduction Multicellular Organismal Homeostasis Actin Cytoskeleton Organization Intracellular Signal Transduction Signaling T Cell Costimulation Actin Filament-based Process Cell Communication Negative Regulation Of Protein Oligomerization Cell Activation Locomotion Actin Filament Organization Regulation Of Hydrogen Peroxide Metabolic Process Organelle Organization Ephrin Receptor Signaling Pathway Regulation Of Respiratory Burst Homeostatic Process Positive Regulation Of Cellular Component Movement Regulation Of Proton Transport Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Anoikis Regulation Of Vesicle-mediated Transport Regulation Of Cell Projection Assembly Movement Of Cell Or Subcellular Component Axon Guidance Membrane Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Lamellipodium Organization Regulation Of Anoikis Positive Regulation Of Immune System Process Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity
Tagcloud ?		17beta caveolae caveolin cgg cingulate copyright coupling demonstration electrophysiological eralpha facilitation fear fmr1 fmrp fragile fxs glua1 inherited interacted ko plasticity potentiation raft recording rescued reserved retardation rights shrna	17q 2q35 5p 6p 9p bcg candidates demonstration dichotomy exacerbation examines helper histocompatibility il4 immunology inbred ity leishmania leishmanial leishmaniasis lsh mexicana mip1 nramp1 parasites pleiotropic positionally reflecting sigje
Tagcloud (Difference) ?		17beta caveolae caveolin cgg cingulate copyright coupling electrophysiological eralpha facilitation fear fmr1 fmrp fragile fxs glua1 inherited interacted ko plasticity potentiation raft recording rescued reserved retardation rights shrna	17q 2q35 5p 6p 9p bcg candidates dichotomy exacerbation examines helper histocompatibility il4 immunology inbred ity leishmania leishmanial leishmaniasis lsh mexicana mip1 nramp1 parasites pleiotropic positionally reflecting sigje
Tagcloud (Intersection) ?		demonstration