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CAV1 and SOS1
Number of citations of the paper that reports this interaction (PubMedID
15976327
)
0
Data Source:
HPRD
(in vivo)
CAV1
SOS1
Description
caveolin 1
SOS Ras/Rac guanine nucleotide exchange factor 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Acrosomal Membrane
Caveolar Macromolecular Signaling Complex
Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Lipid Droplet
Plasma Membrane
Caveola
Focal Adhesion
Cilium
Cell Cortex
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Endocytic Vesicle Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Protein-containing Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Neuronal Cell Body
Glutamatergic Synapse
GTPase Complex
Molecular Function
Signaling Receptor Binding
Patched Binding
Protein Binding
Oxysterol Binding
Cholesterol Binding
Peptidase Activator Activity
Enzyme Binding
Protein Kinase Binding
Protein Tyrosine Kinase Inhibitor Activity
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Nitric-oxide Synthase Inhibitor Activity
Identical Protein Binding
Transmembrane Transporter Binding
Protein-containing Complex Binding
Protein Heterodimerization Activity
Nitric-oxide Synthase Binding
ATPase Binding
Molecular Adaptor Activity
Inward Rectifier Potassium Channel Inhibitor Activity
Protein Sequestering Activity
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Epidermal Growth Factor Receptor Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Protein Heterodimerization Activity
Molecular Condensate Scaffold Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Angiogenesis
Vasculogenesis
Response To Hypoxia
Endothelial Cell Proliferation
Negative Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of The Force Of Heart Contraction
Glandular Epithelial Cell Differentiation
Response To Ischemia
Regulation Of The Force Of Heart Contraction By Chemical Signal
Triglyceride Metabolic Process
Nitric Oxide Biosynthetic Process
Calcium Ion Transport
Intracellular Calcium Ion Homeostasis
Regulation Of Smooth Muscle Contraction
Skeletal Muscle Tissue Development
Lactation
Intracellular Protein Localization
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Cellular Response To Starvation
Response To Bacterium
Negative Regulation Of Signal Transduction
Positive Regulation Of Calcium Ion Transport Into Cytosol
Post-transcriptional Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Positive Regulation Of Cholesterol Efflux
Protein Transport
Vesicle Organization
Receptor-mediated Endocytosis Of Virus By Host Cell
Regulation Of Fatty Acid Metabolic Process
Cytokine-mediated Signaling Pathway
Lipid Storage
Cell Differentiation
Regulation Of Blood Coagulation
Cholesterol Transport
Positive Regulation Of Cell Migration
Negative Regulation Of BMP Signaling Pathway
Negative Regulation Of Epithelial Cell Differentiation
Mammary Gland Development
T Cell Costimulation
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Receptor Internalization
Maintenance Of Protein Location In Cell
Response To Progesterone
Intracellular Nitric Oxide Homeostasis
Toll-like Receptor 4 Signaling Pathway
Regulation Of Toll-like Receptor 4 Signaling Pathway
Insulin Receptor Internalization
Angiotensin-activated Signaling Pathway
Vasoconstriction
Cholesterol Homeostasis
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of MAPK Cascade
Response To Estrogen
Protein Localization To Plasma Membrane Raft
Negative Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Vasoconstriction
Nitric Oxide Metabolic Process
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Muscle Cell Cellular Homeostasis
Fibroblast Proliferation
Negative Regulation Of Fibroblast Proliferation
Negative Regulation Of Pinocytosis
Regulation Of Cytosolic Calcium Ion Concentration
Response To Calcium Ion
Establishment Of Localization In Cell
Membrane Depolarization
Calcium Ion Homeostasis
Mammary Gland Involution
Canonical Wnt Signaling Pathway
Negative Regulation Of Necroptotic Process
Caveola Assembly
Cellular Response To Misfolded Protein
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Hyperoxia
Cellular Response To Transforming Growth Factor Beta Stimulus
Basement Membrane Organization
Caveolin-mediated Endocytosis
Regulation Of Heart Rate By Cardiac Conduction
Negative Regulation Of Canonical Wnt Signaling Pathway
Apoptotic Signaling Pathway
Regulation Of Membrane Repolarization During Action Potential
Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction
Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Ruffle Assembly
Negative Regulation Of Potassium Ion Transmembrane Transport
Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Protein Localization To Basolateral Plasma Membrane
Positive Regulation Of Gap Junction Assembly
Positive Regulation Of ERAD Pathway
Regulation Of Entry Of Bacterium Into Host Cell
Negative Regulation Of Anoikis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
B Cell Homeostasis
Hair Follicle Development
Lymphocyte Homeostasis
Response To Ischemia
Heart Morphogenesis
Cardiac Atrium Morphogenesis
Pericardium Morphogenesis
Regulation Of Transcription By RNA Polymerase II
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase-mediated Signal Transduction
Ras Protein Signal Transduction
Vitellogenesis
Axon Guidance
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Schwann Cell Development
Cytokine-mediated Signaling Pathway
Regulation Of T Cell Differentiation In Thymus
Multicellular Organism Growth
Fc-epsilon Receptor Signaling Pathway
T Cell Activation
Regulation Of Cell Population Proliferation
Regulation Of T Cell Proliferation
Myelination
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Blood Vessel Morphogenesis
B Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Small GTPase Mediated Signal Transduction
Roof Of Mouth Development
Eyelid Development In Camera-type Eye
Heart Trabecula Morphogenesis
Midbrain Morphogenesis
Regulation Of Pro-B Cell Differentiation
Pathways
Triglyceride catabolism
eNOS activation
NOSTRIN mediated eNOS trafficking
Thyroxine biosynthesis
Basigin interactions
Disassembly of the destruction complex and recruitment of AXIN to the membrane
VEGFR2 mediated vascular permeability
RHOA GTPase cycle
Extra-nuclear estrogen signaling
RHOB GTPase cycle
RHOC GTPase cycle
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOD GTPase cycle
RHOQ GTPase cycle
RHOH GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RAC3 GTPase cycle
RHOF GTPase cycle
FOXO-mediated transcription of cell cycle genes
RND3 GTPase cycle
RND2 GTPase cycle
RND1 GTPase cycle
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
SOS-mediated signalling
SOS-mediated signalling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
Signalling to RAS
Signalling to RAS
GRB2 events in EGFR signaling
SHC1 events in EGFR signaling
Downstream signal transduction
NRAGE signals death through JNK
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
Tie2 Signaling
EGFR Transactivation by Gastrin
DAP12 signaling
SHC-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
GRB2:SOS provides linkage to MAPK signaling for Integrins
NCAM signaling for neurite out-growth
G alpha (12/13) signalling events
Activation of RAC1
Constitutive Signaling by EGFRvIII
SHC-mediated cascade:FGFR1
FRS-mediated FGFR1 signaling
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
Signaling by FGFR3 in disease
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor signalling cascade
MET activates RAS signaling
RET signaling
Interleukin-15 signaling
RAC1 GTPase cycle
Activated NTRK2 signals through RAS
Erythropoietin activates RAS
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK3 signals through RAS
Interleukin receptor SHC signaling
FLT3 Signaling
Constitutive Signaling by Overexpressed ERBB2
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Potential therapeutics for SARS
Signaling by CSF1 (M-CSF) in myeloid cells
Signaling by FLT3 fusion proteins
Signaling by FLT3 ITD and TKD mutants
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Signaling by LTK
Drugs
Diseases
Congenital generalized lipodystrophy (CGL)
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Atrial fibrillation (
33990960
22544366
30061737
29892015
28416822
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic traits (
20062063
25055868
)
Electrocardiographic traits (multivariate) (
32602732
)
Glaucoma (
30054594
)
Glaucoma (primary open-angle) (
25173105
29891935
33627673
20835238
)
Heart rate increase in response to exercise (
29497042
)
Heart rate response to recovery post exercise (10 sec) (
29497042
)
Heart rate response to recovery post exercise (20 sec) (
29497042
)
Heart rate response to recovery post exercise (30 sec) (
29497042
)
Heart rate response to recovery post exercise (40 sec) (
29497042
)
Heart rate response to recovery post exercise (50 sec) (
29497042
)
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Immature fraction of reticulocytes (
27863252
32888494
)
Intraocular pressure (
29235454
25173106
28073927
29617998
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte percentage of white cells (
32888494
)
P wave duration (
28794112
)
Platelet distribution width (
32888494
)
PR interval (
20062060
25035420
32439900
30679814
23139255
30046033
29127183
)
PR segment duration (
24850809
)
Proportion of activated microglia (inferior temporal cortex) (
30679421
)
QRS duration (
30012220
)
QT interval (
29874175
24952745
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Aseptic loosening in total joint arthroplasty (
31791832
)
Corticobasal degeneration (
26077951
)
Sensorimotor dexterity (
31596458
)
Interacting Genes
86 interacting genes:
ABCB1
ABL1
AKAP1
APP
AR
BMX
BSG
BST1
BTK
CAV2
CD40
CSK
CSNK2A1
CSNK2A2
DAG1
DANCR
DNM1
EDNRB
EGFR
ERBB2
ESR1
FLNA
FLOT2
FYN
GJA1
GJA3
GJB2
GLP1R
GNAI2
GRB7
GRK1
GRK2
GRK5
HRAS
HTR1F
IGF1R
IGFBP3
ILK
INSR
IRS1
KCNA3
KDR
LRP1
MALL
MAPK1
MAPK3
MMP14
NEU3
NGFR
NOS2
NOS3
NTRK1
PDGFRA
PDGFRB
PLD1
PLD2
PPP1CA
PPP2CA
PRNP
PTEN
PTGS2
PTPN1
PTPN11
PTPN6
PTPRF
RAC1
RCVRN
RHOA
RHOC
S1PR1
SCP2
SNCA
SOS1
SRC
STOML3
STRN
STRN4
TEK
TGFBR1
TNFRSF1B
TRAF2
TRAF4
TRAF6
TRPC1
USP7
VAV2
56 interacting genes:
ABI1
ABI3
ANXA2
ATP6V1E1
BIN1
CAV1
CD19
CD2AP
COPS3
CRK
CRKL
CSF1R
EGFR
EPS8
EPS8L1
EPS8L2
ERBB2
ERBB3
ESR1
FGFR1
FRS2
FYN
GAB1
GRAP
GRB2
HCK
HDLBP
HRAS
ITSN1
ITSN2
LAT2
LCK
MAPK1
MAPK3
MUC1
NCK1
NCK2
PACSIN1
PACSIN3
PIK3R2
PLCG1
PTPN11
PTPN6
RANBP9
RIT2
RRAS
SH3BP5
SH3KBP1
SHC1
SIRPA
SNX18
SNX9
SPTAN1
TNIK
UBASH3A
ZAP70
Entrez ID
857
6654
HPRD ID
03028
01681
Ensembl ID
ENSG00000105974
ENSG00000115904
Uniprot IDs
A9XTE5
Q03135
Q2TNI1
Q59E85
Q7Z4F3
G5E9C8
Q07889
PDB IDs
7SC0
1AWE
1BKD
1DBH
1NVU
1NVV
1NVW
1NVX
1Q9C
1XD2
1XD4
1XDV
2II0
3KSY
4NYI
4NYJ
4NYM
4URU
4URV
4URW
4URX
4URY
4URZ
4US0
4US1
4US2
5OVD
5OVE
5OVF
5OVG
5OVH
5OVI
5WFO
5WFP
5WFQ
5WFR
6BVI
6BVJ
6BVK
6BVL
6BVM
6CUO
6CUP
6CUR
6D55
6D56
6D59
6D5E
6D5G
6D5H
6D5J
6D5L
6D5M
6D5V
6D5W
6EPL
6EPM
6EPN
6EPO
6EPP
6F08
6SCM
6SFR
6V94
6V9F
6V9J
6V9L
6V9M
6V9N
6V9O
6Y44
7AVI
7AVL
7AVS
7AVT
7AVU
7AVV
7KFZ
7UKR
7UKS
8BE2
8BE4
8BE5
8BE6
8BE7
8BE8
8BE9
8BEA
8XJJ
Enriched GO Terms of Interacting Partners
?
Regulation Of Signal Transduction
Plasma Membrane
Regulation Of Cell Communication
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Regulation Of Cell Migration
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Locomotion
Regulation Of Cell Motility
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Regulation Of MAPK Cascade
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Intracellular Signal Transduction
Positive Regulation Of Locomotion
Regulation Of Multicellular Organismal Process
Membrane Raft
Regulation Of Cellular Component Organization
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Positive Regulation Of MAPK Cascade
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Cellular Response To Oxygen-containing Compound
Regulation Of Programmed Cell Death
Negative Regulation Of Signal Transduction
Regulation Of Apoptotic Process
Intracellular Signaling Cassette
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of Biological Quality
Kinase Activity
Protein Phosphorylation
Regulation Of Transport
Regulation Of Protein Metabolic Process
Negative Regulation Of Programmed Cell Death
Membrane
Anatomical Structure Morphogenesis
Phosphorylation
Receptor Complex
Regulation Of ERK1 And ERK2 Cascade
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Enzyme-linked Receptor Protein Signaling Pathway
Intracellular Signal Transduction
Regulation Of Signal Transduction
Plasma Membrane
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Signaling
Intracellular Signaling Cassette
Peptidyl-tyrosine Phosphorylation
ERBB Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Cellular Component Organization
Antigen Receptor-mediated Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Positive Regulation Of MAPK Cascade
Cell Migration
Positive Regulation Of Intracellular Signal Transduction
Immune Response-activating Signaling Pathway
Positive Regulation Of Cellular Component Organization
T Cell Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Regulation Of Immune System Process
Regulation Of Developmental Process
Cell Motility
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Signaling
Regulation Of Immune Response
Regulation Of Actin Filament-based Process
Response To Growth Factor
Cytosol
Receptor Tyrosine Kinase Binding
Schwann Cell Development
Cytoplasm
Regulation Of Cell Adhesion
Positive Regulation Of Cell Adhesion
Positive Regulation Of Cell Communication
Regulation Of Actin Cytoskeleton Organization
Regulation Of Cytoskeleton Organization
Endocytosis
Regulation Of Anatomical Structure Morphogenesis
Cell Development
MAPK Cascade
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