PDCL and CCT5

Number of citations of the paper that reports this interaction (PubMedID 15889144)
36

Data Source:
HPRD (in vivo)

		PDCL	CCT5
Description		phosducin like	chaperonin containing TCP1 subunit 5
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cilium Cell Projection	Cytoplasm Centrosome Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Cell Body Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding MRNA 3'-UTR Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity G-protein Beta-subunit Binding Protein Folding Chaperone MRNA 5'-UTR Binding Beta-tubulin Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Signal Transduction Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Positive Regulation Of Smoothened Signaling Pathway Heterotrimeric G-protein Complex Assembly	Protein Folding Binding Of Sperm To Zona Pellucida Response To Virus Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Metabolite levels ( 23823483) Pain ( 22956598)
Interacting Genes		10 interacting genes: CCT5 GNB1 GNGT1 GRK2 IKBKG LRRK2 MFHAS1 MRPL11 PSMC5 TCP1	23 interacting genes: ACTA1 ACTA2 ACTB CEBPA DCAF12 DUXAP9 ELP1 ERCC6 HDAC3 IMMT MCPH1 OGT PDCL SPMAP2 SUMO2 SUMO4 TBC1D17 TCP1 TERT TP53 VHL XRN1 ZNRD2
Entrez ID		5082	22948
HPRD ID		05108	06468
Ensembl ID		ENSG00000136940	ENSG00000150753
Uniprot IDs		Q13371	B4DDU6 B4DX08 B4DYC8 B7ZAR1 E7ENZ3 E9PCA1 P48643 V9HW37
PDB IDs		8SFF 8SG8 8SGC 8SH9 8SHA 8SHF 8SHG 8SHL 8SHO 8SHP 8SHQ 8SHT	5UYX 5UYZ 6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8 7LUM 7LUP 7NVL 7NVM 7NVN 7NVO 7TRG 7TTN 7TTT 7TUB 7WU7 7WZ3 7X0A 7X0S 7X0V 7X3J 7X3U 7X6Q 7X7Y 8AJM 8AJO 8HKI 8I1U 8I9U 8IB8 8SFE 8SFF 8SG8 8SG9 8SGC 8SGL 8SGQ 8SH9 8SHA 8SHD 8SHE 8SHF 8SHG 8SHL 8SHN 8SHO 8SHP 8SHQ 8SHT
Enriched GO Terms of Interacting Partners?		Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Regulation Of Telomerase RNA Localization To Cajal Body G Protein-coupled Acetylcholine Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Response To Catecholamine Photoreceptor Disc Membrane G-protein Beta-subunit Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Protein Localization To Nucleus Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Binding Of Sperm To Zona Pellucida Nucleotide Binding Signaling Receptor Complex Adaptor Activity Heterotrimeric G-protein Complex Positive Regulation Of Proteolysis ATP-dependent Protein Folding Chaperone Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Sperm-egg Recognition Acetylcholine Receptor Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Postsynaptic Signal Transduction Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Protein Folding Chaperone Cell-cell Recognition Regulation Of Macrophage Activation Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Ubiquitin Protein Ligase Binding ATP Binding Photoreceptor Outer Segment GTPase Activity Positive Regulation Of Telomere Maintenance Edg-2 Lysophosphatidic Acid Receptor Binding Nuclear Proteasome Complex ATP Hydrolysis Activity Regulation Of Proteolysis Cell Body Regulation Of Protein Stability Regulation Of DNA Biosynthetic Process	Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Mesenchyme Migration Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of RNA Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Protein Localization To Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Protein Stability Regulation Of Metabolic Process Cell Body Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Initiation Protein Tag Activity Replicative Senescence Regulation Of Stem Cell Proliferation Regulation Of DNA Biosynthetic Process Chromatin DNA Binding Regulation Of Primary Metabolic Process Positive Regulation Of Protein Localization To Nucleus Regulation Of Cell Cycle Mitochondrion Organization Negative Regulation Of Telomere Maintenance Via Telomerase PML Body Regulation Of Telomere Maintenance Telomerase RNA Binding Regulation Of DNA Metabolic Process Regulation Of Protein Metabolic Process Ubiquitin-like Protein Ligase Binding Regulation Of RNA Metabolic Process Negative Regulation Of Stem Cell Proliferation Response To X-ray Nuclear Matrix Histone Deacetylase Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Circadian Rhythm Negative Regulation Of DNA Metabolic Process Cellular Response To Hypoxia Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
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