PDCL and GNGT1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, affinity chromatography technology)

		PDCL	GNGT1
Description		phosducin like	G protein subunit gamma transducin 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cilium Cell Projection	Photoreceptor Outer Segment Photoreceptor Inner Segment Heterotrimeric G-protein Complex Plasma Membrane Membrane Photoreceptor Disc Membrane
	Molecular Function	Protein Binding	GTPase Activity Protein Binding G-protein Beta-subunit Binding
	Biological Process	Signal Transduction Visual Perception Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Projection Organization Positive Regulation Of Smoothened Signaling Pathway Heterotrimeric G-protein Complex Assembly	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phototransduction Intracellular Protein Localization Cardiac Muscle Cell Apoptotic Process Eye Photoreceptor Cell Development Cellular Response To Hypoxia
Pathways		Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Activation of G protein gated Potassium channels G-protein activation Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Appendicular lean mass ( 33097823) Body mass index ( 28552196) Body size at age 10 ( 32376654) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Mosquito bite size ( 28199695) Resting heart rate ( 27798624 29769521) Taxane-induced peripheral neuropathy in breast cancer ( 29278617)
Interacting Genes		10 interacting genes: CCT5 GNB1 GNGT1 GRK2 IKBKG LRRK2 MFHAS1 MRPL11 PSMC5 TCP1	14 interacting genes: GNAS GNB1 GNB2 GNB4 GNB5 GORASP2 IKBKG MSANTD4 NAGA PDCL PLEKHB1 RHO UBXN4 ZNF277
Entrez ID		5082	2792
HPRD ID		05108	01805
Ensembl ID		ENSG00000136940	ENSG00000127928
Uniprot IDs		Q13371	P63211
PDB IDs		8SFF 8SG8 8SGC 8SH9 8SHA 8SHF 8SHG 8SHL 8SHO 8SHP 8SHQ 8SHT	7L0P 7L0Q 7L0R 7L0S
Enriched GO Terms of Interacting Partners?		Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Regulation Of Telomerase RNA Localization To Cajal Body G Protein-coupled Acetylcholine Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Response To Catecholamine Photoreceptor Disc Membrane G-protein Beta-subunit Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Protein Localization To Nucleus Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Binding Of Sperm To Zona Pellucida Nucleotide Binding Signaling Receptor Complex Adaptor Activity Heterotrimeric G-protein Complex Positive Regulation Of Proteolysis ATP-dependent Protein Folding Chaperone Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Sperm-egg Recognition Acetylcholine Receptor Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process Postsynaptic Signal Transduction Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Relaxation Of Smooth Muscle Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Protein Folding Chaperone Cell-cell Recognition Regulation Of Macrophage Activation Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Ubiquitin Protein Ligase Binding ATP Binding Photoreceptor Outer Segment GTPase Activity Positive Regulation Of Telomere Maintenance Edg-2 Lysophosphatidic Acid Receptor Binding Nuclear Proteasome Complex ATP Hydrolysis Activity Regulation Of Proteolysis Cell Body Regulation Of Protein Stability Regulation Of DNA Biosynthetic Process	Heterotrimeric G-protein Complex Signaling Receptor Complex Adaptor Activity G Protein-coupled Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway GTPase Activity Response To Catecholamine Cellular Response To Prostaglandin E Stimulus Cellular Response To Catecholamine Stimulus Response To Light Intensity Photoreceptor Disc Membrane Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Sensory Perception GTPase Binding Phototransduction Alpha-N-acetylgalactosaminidase Activity Heterotrimeric G-protein Complex Assembly Rod Bipolar Cell Differentiation GTPase Activator Complex G-protein Gamma-subunit Binding Detection Of Light Stimulus Mu-type Opioid Receptor Binding Photoreceptor Outer Segment Alpha-galactosidase Activity Thermotaxis Dark Adaptation Retina Development In Camera-type Eye Signal Transduction Response To Light Stimulus Sperm Head Plasma Membrane Linear Polyubiquitin Binding Light Adaption Response To Unfolded Protein Protein-containing Complex Binding Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Regulator Activity Lysosomal Membrane Photoreceptor Inner Segment Membrane Absorption Of Visible Light Sensory Perception Of Chemical Stimulus Cellular Response To Light Stimulus Hair Follicle Placode Formation Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Detection Of Temperature Stimulus Involved In Thermoception G Protein-coupled Opsin Signaling Pathway 11-cis Retinal Binding Detection Of Abiotic Stimulus Nervous System Process
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