ADRB3 and WRN

Data Source: HiPPIP (Novel)

		ADRB3	WRN
Name		adrenoceptor beta 3	WRN RecQ like helicase
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Nucleolus Cytoplasm Centrosome Nuclear Speck
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Beta-adrenergic Receptor Activity Protein Binding Beta3-adrenergic Receptor Activity Beta-3 Adrenergic Receptor Binding Protein Homodimerization Activity Epinephrine Binding Norepinephrine Binding	Nucleotide Binding Magnesium Ion Binding Four-way Junction DNA Binding Y-form DNA Binding Bubble DNA Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Catalytic Activity Helicase Activity Nuclease Activity Exonuclease Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Four-way Junction Helicase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Manganese Ion Binding MutLalpha Complex Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity Protein-containing Complex Binding Metal Ion Binding G-quadruplex DNA Binding Forked DNA-dependent Helicase Activity Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding 3'-flap-structured DNA Binding Catalytic Activity, Acting On DNA 8-hydroxy-2'-deoxyguanosine DNA Binding
	Biological Process	Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Carbohydrate Metabolic Process Generation Of Precursor Metabolites And Energy Energy Reserve Metabolic Process Receptor-mediated Endocytosis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Cold Heat Generation Negative Regulation Of Multicellular Organism Growth Eating Behavior Positive Regulation Of MAPK Cascade Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Brown Fat Cell Differentiation Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Synthesis Involved In DNA Repair Nucleobase-containing Compound Metabolic Process DNA Metabolic Process DNA Replication DNA Repair Base-excision Repair Mismatch Repair Double-strand Break Repair DNA Recombination DNA Damage Response Response To Oxidative Stress Determination Of Adult Lifespan Cellular Response To Starvation Response To UV-C Replication Fork Processing Telomere Maintenance Via Semi-conservative Replication DNA Geometric Change Regulation Of Growth Rate Positive Regulation Of Hydrolase Activity Telomeric D-loop Disassembly Cellular Response To Gamma Radiation Cellular Senescence Replicative Senescence T-circle Formation Positive Regulation Of Strand Invasion Protein Localization To Nucleolus
Pathways		Adrenoceptors G alpha (s) signalling events	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs		Amphetamine Bethanidine Metoprolol Dihydroergotamine Olanzapine Norepinephrine Nortriptyline Propranolol Paroxetine Trimipramine Cryptenamine Alprenolol Ritodrine Terbutaline Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Fenoterol Ephedra sinica root Mephentermine Clenbuterol Oxprenolol Celiprolol Nebivolol Amibegron Solabegron Droxidopa Bufuralol Bopindolol Bupranolol Mirabegron Racepinephrine Dihydroergocornine DL-Methylephedrine Dihydroergocristine Vibegron	None
Diseases		None	Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
GWAS		No GWAS studies recorded	Chronotype ( 30696823 ) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903 ) Daytime sleep phenotypes ( 27126917 ) Exercise treadmill test traits ( 17903301 ) Fasting glucose change (long-term) ( 31263163 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Intelligence (MTAG) ( 29326435 ) Lifespan ( 25918517 ) Logical memory (delayed recall) in mild cognitive impairment ( 29274321 ) Logical memory (immediate recall) in mild cognitive impairment ( 29274321 ) Metabolite levels ( 23823483 ) Morning person ( 30696823 )
Novel Interactors		3 novel interactors: IDO1 UBXN8 WRN	4 novel interactors: ADRB3 HTR5A LINC03042 UBXN8
Interacting Genes		4 interacting genes: ADRB2 CFTR GNAS SRC	34 interacting genes: ATM ATRX BARD1 BLM BRCA1 CDKN2A FEN1 H2AX MDC1 MDM2 MIB1 PARP1 PCNA POLB POLD2 POLK POLR1C PRKAR1B PRKDC RAD1 RAD51 RAD52 RAD54B RAD9A RPA1 RPA2 SUMO1 SUMO2 TERF2 TP53 VCP WRNIP1 XRCC5 XRCC6
Entrez ID		155	7486
HPRD ID		00188	05212
Ensembl ID		ENSG00000188778	ENSG00000165392
Uniprot IDs		A8KAG8 P13945	Q14191
PDB IDs		9IJD 9IJE	2AXL 2DGZ 2E1E 2E1F 2FBT 2FBV 2FBX 2FBY 2FC0 3AAF 6TYV 6YHR 7GQS 7GQT 7GQU 7XUT 8PFL 8PFO 8PFP 8YLE
GO Terms Enriched among Interactors		Response To Stress Negative Regulation Of Multicellular Organism Growth Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Multicellular Organismal-level Homeostasis Adrenergic Receptor Signaling Pathway Bone Resorption Reproductive Process Multicellular Organismal-level Water Homeostasis Response To Ketone Ionotropic Glutamate Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Stress Response To Fluid Shear Stress Response To Lipid Positive Regulation Of Biomineral Tissue Development Vasodilation Cellular Response To Oxygen-containing Compound Positive Regulation Of Catalytic Activity Enzyme Binding Clathrin-coated Endocytic Vesicle Membrane Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Apical Plasma Membrane Regulation Of Multicellular Organism Growth Positive Regulation Of Mini Excitatory Postsynaptic Potential Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multicellular Organismal-level Chemical Homeostasis Positive Regulation Of Strand Invasion 3'-flap-structured DNA Binding Female Pregnancy Regulation Of Inflammatory Response Regulation Of Membrane Potential Negative Regulation Of Developmental Growth Beta2-adrenergic Receptor Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cold-induced Thermogenesis Odontogenesis Positive Regulation Of Anion Channel Activity Cellular Response To Lipid Mu-type Opioid Receptor Binding Kynurenic Acid Biosynthetic Process Indoleamine 2,3-dioxygenase Activity Swimming Behavior Forked DNA-dependent Helicase Activity Homeostatic Process Negative Regulation Of Immune System Process Heme Binding Regulation Of Vesicle-mediated Transport	DNA Repair DNA Damage Response DNA Metabolic Process Cellular Response To Stress Response To Ionizing Radiation Double-strand Break Repair Nucleic Acid Metabolic Process Damaged DNA Binding Chromosome, Telomeric Region Response To Radiation DNA Recombination Recombinational Repair Cellular Response To Radiation Nucleobase-containing Compound Metabolic Process Response To Stress Telomere Maintenance Cellular Response To Ionizing Radiation Telomere Organization Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Signal Transduction In Response To DNA Damage Response To Gamma Radiation Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Chromosome Organization Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process Protein Localization To Chromosome Nucleoplasm Regulation Of Cell Cycle Process Regulation Of DNA Repair DNA Binding Regulation Of Cell Cycle Phase Transition DNA Biosynthetic Process Site Of Double-strand Break Enzyme Binding Negative Regulation Of Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Nuclear Body Regulation Of Cell Cycle DNA Replication Cellular Response To Gamma Radiation Protein Localization To Organelle PML Body Replication Fork Processing Protein-containing Complex Regulation Of DNA Recombination Negative Regulation Of Mitotic Cell Cycle