ADRB3 and IDO1

Data Source: HiPPIP (Novel)

		ADRB3	IDO1
Name		adrenoceptor beta 3	indoleamine 2,3-dioxygenase 1
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Cytoplasm Cytosol Smooth Muscle Contractile Fiber Stereocilium Bundle
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Beta-adrenergic Receptor Activity Protein Binding Beta3-adrenergic Receptor Activity Beta-3 Adrenergic Receptor Binding Protein Homodimerization Activity Epinephrine Binding Norepinephrine Binding	Tryptophan 2,3-dioxygenase Activity Electron Transfer Activity Oxidoreductase Activity Heme Binding Indoleamine 2,3-dioxygenase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Carbohydrate Metabolic Process Generation Of Precursor Metabolites And Energy Energy Reserve Metabolic Process Receptor-mediated Endocytosis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Cold Heat Generation Negative Regulation Of Multicellular Organism Growth Eating Behavior Positive Regulation Of MAPK Cascade Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Brown Fat Cell Differentiation Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Immune System Process Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Type 2 Immune Response L-tryptophan Catabolic Process Inflammatory Response Female Pregnancy L-tryptophan Catabolic Process To Kynurenine Quinolinate Biosynthetic Process Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Multicellular Organismal Response To Stress Kynurenic Acid Biosynthetic Process 'de Novo' NAD+ Biosynthetic Process From L-tryptophan Swimming Behavior T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of T Cell Apoptotic Process
Pathways		Adrenoceptors G alpha (s) signalling events	Tryptophan catabolism
Drugs		Amphetamine Bethanidine Metoprolol Dihydroergotamine Olanzapine Norepinephrine Nortriptyline Propranolol Paroxetine Trimipramine Cryptenamine Alprenolol Ritodrine Terbutaline Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Fenoterol Ephedra sinica root Mephentermine Clenbuterol Oxprenolol Celiprolol Nebivolol Amibegron Solabegron Droxidopa Bufuralol Bopindolol Bupranolol Mirabegron Racepinephrine Dihydroergocornine DL-Methylephedrine Dihydroergocristine Vibegron	Nitric Oxide Cannabidiol Medical Cannabis Nabiximols
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		3 novel interactors: IDO1 UBXN8 WRN	6 novel interactors: ADRB3 DCTN6 DUSP4 RBPMS SFRP1 SLC20A2
Interacting Genes		4 interacting genes: ADRB2 CFTR GNAS SRC	5 interacting genes: APP DDX24 FBXL17 PPP1R16A TERF2IP
Entrez ID		155	3620
HPRD ID		00188	00935
Ensembl ID		ENSG00000188778	ENSG00000131203
Uniprot IDs		A8KAG8 P13945	A0A348GSI3 P14902
PDB IDs		9IJD 9IJE	2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW 5WHR 5WMU 5WMV 5WMW 5WMX 5WN8 5XE1 6AZU 6AZV 6AZW 6CXU 6CXV 6DPQ 6DPR 6E35 6E40 6E41 6E42 6E43 6E44 6E45 6E46 6F0A 6KOF 6KPS 6KW7 6MQ6 6O3I 6PU7 6PZ1 6R63 6UBP 6V52 6WJY 6WPE 6X5Y 7A62 7AH4 7AH5 7AH6 7B1O 7E0O 7E0P 7E0Q 7E0S 7E0T 7E0U 7M63 7M7D 7NGE 7P0N 7P0R 7RRB 7RRC 7RRD 7YXT 7Z2L 7ZV3 8ABX 8FUR 8I7L 8U5I 9ESB 9ESC 9ESE 9ESG
GO Terms Enriched among Interactors		Response To Stress Negative Regulation Of Multicellular Organism Growth Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Multicellular Organismal-level Homeostasis Adrenergic Receptor Signaling Pathway Bone Resorption Reproductive Process Multicellular Organismal-level Water Homeostasis Response To Ketone Ionotropic Glutamate Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Stress Response To Fluid Shear Stress Response To Lipid Positive Regulation Of Biomineral Tissue Development Vasodilation Cellular Response To Oxygen-containing Compound Positive Regulation Of Catalytic Activity Enzyme Binding Clathrin-coated Endocytic Vesicle Membrane Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Apical Plasma Membrane Regulation Of Multicellular Organism Growth Positive Regulation Of Mini Excitatory Postsynaptic Potential Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multicellular Organismal-level Chemical Homeostasis Positive Regulation Of Strand Invasion 3'-flap-structured DNA Binding Female Pregnancy Regulation Of Inflammatory Response Regulation Of Membrane Potential Negative Regulation Of Developmental Growth Beta2-adrenergic Receptor Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cold-induced Thermogenesis Odontogenesis Positive Regulation Of Anion Channel Activity Cellular Response To Lipid Mu-type Opioid Receptor Binding Kynurenic Acid Biosynthetic Process Indoleamine 2,3-dioxygenase Activity Swimming Behavior Forked DNA-dependent Helicase Activity Homeostatic Process Negative Regulation Of Immune System Process Heme Binding Regulation Of Vesicle-mediated Transport	None