ADRB3 and UBXN8

Data Source: HiPPIP (Novel)

		ADRB3	UBXN8
Name		adrenoceptor beta 3	UBX domain protein 8
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Receptor Complex	Ubiquitin Ligase Complex Nucleoplasm Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Beta-adrenergic Receptor Activity Protein Binding Beta3-adrenergic Receptor Activity Beta-3 Adrenergic Receptor Binding Protein Homodimerization Activity Epinephrine Binding Norepinephrine Binding	Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Binding
	Biological Process	Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Carbohydrate Metabolic Process Generation Of Precursor Metabolites And Energy Energy Reserve Metabolic Process Receptor-mediated Endocytosis Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Cold Heat Generation Negative Regulation Of Multicellular Organism Growth Eating Behavior Positive Regulation Of MAPK Cascade Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Brown Fat Cell Differentiation Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis	Single Fertilization ERAD Pathway
Pathways		Adrenoceptors G alpha (s) signalling events	None
Drugs		Amphetamine Bethanidine Metoprolol Dihydroergotamine Olanzapine Norepinephrine Nortriptyline Propranolol Paroxetine Trimipramine Cryptenamine Alprenolol Ritodrine Terbutaline Salmeterol Pindolol Formoterol Salbutamol Ergoloid mesylate Isoprenaline Arbutamine Amiodarone Fenoterol Ephedra sinica root Mephentermine Clenbuterol Oxprenolol Celiprolol Nebivolol Amibegron Solabegron Droxidopa Bufuralol Bopindolol Bupranolol Mirabegron Racepinephrine Dihydroergocornine DL-Methylephedrine Dihydroergocristine Vibegron	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		3 novel interactors: IDO1 UBXN8 WRN	6 novel interactors: ADRB3 DCTN6 LINC03042 RBPMS SFRP1 WRN
Interacting Genes		4 interacting genes: ADRB2 CFTR GNAS SRC	7 interacting genes: AQP6 GJA8 HSD17B13 MEOX2 PGRMC2 SPCS1 TMEM14B
Entrez ID		155	7993
HPRD ID		00188	03692
Ensembl ID		ENSG00000188778	ENSG00000104691
Uniprot IDs		A8KAG8 P13945	A0A087WUA4 A0A087WV67 B4DKK1 O00124
PDB IDs		9IJD 9IJE	Not available
GO Terms Enriched among Interactors		Response To Stress Negative Regulation Of Multicellular Organism Growth Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Multicellular Organismal-level Homeostasis Adrenergic Receptor Signaling Pathway Bone Resorption Reproductive Process Multicellular Organismal-level Water Homeostasis Response To Ketone Ionotropic Glutamate Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Stress Response To Fluid Shear Stress Response To Lipid Positive Regulation Of Biomineral Tissue Development Vasodilation Cellular Response To Oxygen-containing Compound Positive Regulation Of Catalytic Activity Enzyme Binding Clathrin-coated Endocytic Vesicle Membrane Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Apical Plasma Membrane Regulation Of Multicellular Organism Growth Positive Regulation Of Mini Excitatory Postsynaptic Potential Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multicellular Organismal-level Chemical Homeostasis Positive Regulation Of Strand Invasion 3'-flap-structured DNA Binding Female Pregnancy Regulation Of Inflammatory Response Regulation Of Membrane Potential Negative Regulation Of Developmental Growth Beta2-adrenergic Receptor Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Cold-induced Thermogenesis Odontogenesis Positive Regulation Of Anion Channel Activity Cellular Response To Lipid Mu-type Opioid Receptor Binding Kynurenic Acid Biosynthetic Process Indoleamine 2,3-dioxygenase Activity Swimming Behavior Forked DNA-dependent Helicase Activity Homeostatic Process Negative Regulation Of Immune System Process Heme Binding Regulation Of Vesicle-mediated Transport	None