ADRA2B and YWHAZ

Number of citations of the paper that reports this interaction (PMID 10224112)
17

Data Source:
HPRD (in vitro)

		ADRA2B	YWHAZ
Gene Name		adrenoceptor alpha 2B	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Focal Adhesion Postsynaptic Density Cytoplasmic Vesicle Membrane Cell Leading Edge Melanosome Mast Cell Granule Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Alpha2-adrenergic Receptor Activity Protein Binding Epinephrine Binding	Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Domain Specific Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	MAPK Cascade Angiogenesis Regulation Of Vascular Smooth Muscle Contraction G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Blood Coagulation Negative Regulation Of Norepinephrine Secretion Platelet Activation Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Neuron Differentiation Positive Regulation Of Blood Pressure Positive Regulation Of Uterine Smooth Muscle Contraction Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway	Histamine Secretion By Mast Cell Protein Targeting To Mitochondrion Apoptotic Process Signal Transduction Blood Coagulation Gene Expression Platelet Activation Response To Drug Negative Regulation Of Apoptotic Process Establishment Of Golgi Localization Membrane Organization Golgi Reassembly Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Adrenaline signalling through Alpha-2 adrenergic receptor Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Platelet Aggregation (Plug Formation) GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Adrenoceptors G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation	Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Signaling by Wnt deactivation of the beta-catenin transactivating complex Rap1 signalling RNF mutants show enhanced WNT signaling and proliferation Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN Intrinsic Pathway for Apoptosis Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Cytokine Signaling in Immune system Activation of BAD and translocation to mitochondria Signaling by Interleukins TCF dependent signaling in response to WNT KSRP destabilizes mRNA GP1b-IX-V activation signalling Signaling by WNT in cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System
Drugs		Bethanidine Ziprasidone Cabergoline Ropinirole Etomidate Olanzapine Clozapine Norepinephrine Pramipexole Brimonidine Clonidine Lisuride Epinephrine Ergotamine Tizanidine Apomorphine Trimipramine Risperidone Fenoldopam Phenoxybenzamine Doxepin Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra Yohimbine Methotrimeprazine Methamphetamine Dronedarone Rotigotine Asenapine Droxidopa Xylometazoline
Diseases
GWAS			Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		5 interactors: EIF2B1 GNAI2 PPP1R9B UCHL1 YWHAZ	191 interactors: AANAT ABL1 ADAM22 ADRA2A ADRA2B ADRA2C AKAP13 AKT1 APP ARAF ARHGEF2 ATP5A1 ATXN1 BAD BCAR1 BCR BRAF BSPRY CBL CDC25A CDC25B CDC25C CDC5L CDK11B CDK16 CDK17 CDKN1B CENPJ CFL1 CGNL1 CLIC4 CRTC2 CSF2RB CSNK1A1 CSNK1D DFFA DISC1 EFNB3 EGFR EIF3A ENO1 EPB41L1 EPB41L2 EPB41L3 EXO1 FAM13B FAM53C FHOD1 FOXO1 FOXO3 FOXO4 GABARAPL2 GABBR1 GCH1 GP1BA GP1BB GP5 HDAC4 HDAC9 HIST1H3A HIVEP2 HMGN1 HSPA1A HSPA1B IGF1R IL9R ING1 INPP5A IRS1 IRS2 KCNK15 KCNK3 KCNK9 KIAA0232 KIAA0930 KIAA1377 KIF1C KIF5B KLC2 KLC4 KLF11 KRT18 KSR1 LARP1 LCP2 LIMK1 LRMP LYST MADD MAP2K5 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK8 MAPKAPK2 MAPT MARK2 MARK3 MARK4 MDM4 MEF2C MINK1 MLF1 MPHOSPH9 MSL2 MST1R MYH9 NEDD4L NFATC2 NFATC4 NR4A1 PAK1 PAK4 PARD3 PARD6A PARD6B PDC PFKFB2 PIAS1 PPP1CC PPP1R14A PRDX2 PRKCA PRKCD PRKCI PRKCZ PRKD1 PRLR PRMT5 PSMA5 PTPN13 PTPRO RAF1 RALGPS2 RAP1GAP2 RASAL3 REM1 RFWD2 RGS3 RIN1 RMDN3 RPRD1A RRAD SAMSN1 SH3GL1 SIK1 SIK3 SIMC1 SLC8A2 SNX24 SORBS2 SQSTM1 SSFA2 SSX2IP STK25 STK38 SYN2 SYNPO SYNPO2 TAB2 TBXA2R TERT TH TJP2 TLK2 TNFAIP3 TNS1 TP53 TPD52L1 TPH1 TRA2B TRIM21 TSC1 TSC2 TUBB UBC UBE3A UCHL5 UCP2 UCP3 VCP VIM WEE1 WNK1 WNK2 WWTR1 XRCC6 YWHAE ZAK ZNF839
Entrez ID		151	7534
HPRD ID		00086	03183
Ensembl ID		ENSG00000222040	ENSG00000164924
Uniprot IDs		A2RUS0 P18089	D0PNI1 P63104
PDB IDs		2CVA	1IB1 1QJA 1QJB 2C1J 2C1N 2O02 2WH0 3CU8 3NKX 3RDH 4BG6 4FJ3 4HKC 4IHL
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Opioid Receptor Signaling Pathway Regulation Of Catalytic Activity Cellular Response To Morphine Platelet Activation Golgi Reassembly Axon Target Recognition Cellular Response To Isoquinoline Alkaloid Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Axon Transport Of Mitochondrion Histamine Secretion By Mast Cell Negative Regulation Of Translational Initiation In Response To Stress Regulation Of Signaling Establishment Of Golgi Localization Golgi Inheritance Regulation Of Phosphorylation Regulation Of Synaptic Transmission Negative Regulation Of Translation In Response To Stress Histamine Secretion Response To Stress Regulation Of Phosphorus Metabolic Process Regulation Of Translational Initiation In Response To Stress Histamine Transport Regulation Of Exit From Mitosis Adenosine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Blood Coagulation Neurogenesis Hemostasis Golgi Localization Regulation Of Translation In Response To Stress Response To Extracellular Stimulus Filopodium Assembly Cell Development Negative Regulation Of Translational Initiation Mast Cell Degranulation Cellular Response To Ammonium Ion Intracellular Signal Transduction Production Of Molecular Mediator Involved In Inflammatory Response Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Lyase Activity Response To Stimulus Mast Cell Mediated Immunity Regulation Of Body Fluid Levels Lysosome Localization	Intracellular Signal Transduction Cell Communication Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Signal Transduction Regulation Of Kinase Activity Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Protein Kinase Activity Response To Stress Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Signal Transduction Protein Phosphorylation Neurotrophin Signaling Pathway Response To Growth Factor Positive Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Response To Organic Substance Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Cellular Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Death Regulation Of MAPK Cascade Apoptotic Process Cell Death Death Programmed Cell Death Positive Regulation Of Protein Modification Process Phosphate-containing Compound Metabolic Process Regulation Of Apoptotic Process Innate Immune Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization
Tagcloud ?		adra1a adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill	actb arfgap2 arl1 bestkeeper bmi1 casc3 cynomolgus ddx3x gapdh genorm lists monkey morf4 mrfap1 normalization normfinder ormdl1 prerequisite reference ribosylation rps19 rsl24d1 sar1a traditionally transcriptome usp22 vitally zc3h11a zranb2
Tagcloud (Difference) ?		adra1a adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill	actb arfgap2 arl1 bestkeeper bmi1 casc3 cynomolgus ddx3x gapdh genorm lists monkey morf4 mrfap1 normalization normfinder ormdl1 prerequisite reference ribosylation rps19 rsl24d1 sar1a traditionally transcriptome usp22 vitally zc3h11a zranb2
Tagcloud (Intersection) ?