ADRA2B and GGA2

Number of citations of the paper that reports this interaction (PubMedID 27901063)
77

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ADRA2B	GGA2
Description		adrenoceptor alpha 2B	golgi associated, gamma adaptin ear containing, ARF binding protein 2
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell Surface Membrane	Endosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Membrane Clathrin-coated Vesicle Early Endosome Membrane
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Protein Binding Epinephrine Binding	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding
	Biological Process	Regulation Of Vascular Associated Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Platelet Activation Negative Regulation Of Epinephrine Secretion Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Blood Pressure Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway	Intracellular Protein Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle-mediated Transport Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport
Pathways		Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor G alpha (i) signalling events G alpha (z) signalling events	TBC/RABGAPs Amyloid fiber formation
Drugs		Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Etomidate Dihydroergotamine Clozapine Norepinephrine Phenylpropanolamine Loxapine Prochlorperazine Prazosin Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Clonidine Lisuride Guanabenz Epinephrine Tizanidine Apomorphine Paroxetine Trimipramine Risperidone Tolazoline Fenoldopam Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Guanfacine Ergoloid mesylate Promethazine Carvedilol Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine Dextroamphetamine Metamfetamine Celiprolol Dronedarone Rotigotine OPC-28326 Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Esmirtazapine Xylometazoline Levonordefrin Tetryzoline Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine Xylazine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Monocyte percentage of white cells ( 32888494)
Interacting Genes		8 interacting genes: EIF2B1 GGA1 GGA2 GGA3 GNAI2 PPP1R9B UCHL1 YWHAZ	43 interacting genes: ADRA2B AFTPH AP1G1 APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC ETS1 FBXO7 GGA1 GGA3 GOLGA2 GTPBP4 HGS HTT IGF2R JUN LRP3 M6PR MAP3K1 MEMO1 NPM1 PIN1 RABEP1 RABGEF1 RNF11 RTN4IP1 SORL1 SORT1 SPG21 STAB1 SYNRG TOLLIP TP53 TRIM23 VPS18 ZNF536
Entrez ID		151	23062
HPRD ID		00086	09347
Ensembl ID		ENSG00000274286	ENSG00000103365
Uniprot IDs		P18089	Q9UJY4
PDB IDs		6K41 6K42	1MHQ
Enriched GO Terms of Interacting Partners?		Ubiquitin Binding Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Protein Localization To Cell Periphery Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Vesicle-mediated Transport To The Plasma Membrane Trans-Golgi Network Protein Localization To Plasma Membrane Early Endosome Membrane Establishment Of Protein Localization To Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Hippocampal Mossy Fiber To CA3 Synapse Endosome Membrane Small GTPase Binding Golgi Vesicle Transport Cellular Response To Xenobiotic Stimulus Establishment Of Localization In Cell Protein Localization To Membrane Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Synaptic Target Recognition Intracellular Protein Localization Protein Metabolic Process Axon Target Recognition Omega Peptidase Activity Male Germ Cell Proliferation D2 Dopamine Receptor Binding Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Opioid Receptor Signaling Pathway Cellular Response To Morphine Eukaryotic Translation Initiation Factor 2B Complex Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Alpha-2A Adrenergic Receptor Binding Positive Regulation Of Catabolic Process Intracellular Transport Transmembrane Transporter Binding Golgi Reassembly Localization Within Membrane Intracellular Protein Transport Positive Regulation Of Lysosomal Protein Catabolic Process Protein Localization To Actin Cytoskeleton Response To Kainic Acid Dendritic Spine Head	Vesicle-mediated Transport Intracellular Transport Early Endosome Endosome Cellular Localization Establishment Of Protein Localization Establishment Of Localization In Cell Protein Transport Intracellular Protein Transport Endocytosis Golgi Apparatus Lysosomal Transport Trans-Golgi Network Import Into Cell Intracellular Protein Localization Vacuolar Transport Clathrin-coated Vesicle Golgi Vesicle Transport Recycling Endosome Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Protein Targeting To Lysosome Protein Targeting Perinuclear Region Of Cytoplasm Establishment Of Protein Localization To Organelle Protein Targeting To Vacuole Protein-containing Complex Trans-Golgi Network Membrane Protein Localization To Lysosome Endosome Membrane Establishment Of Protein Localization To Vacuole Early Endosome Membrane Cytoplasmic Vesicle Cytosolic Transport Clathrin-coated Pit Retromer Complex Binding Golgi To Lysosome Transport Nuclear Envelope Lumen Lysosome Protein Localization To Organelle AP-1 Adaptor Complex Endosomal Transport Protein Localization To Vacuole Ubiquitin Binding Protein Transporter Activity Regulation Of Amyloid Precursor Protein Catabolic Process Trans-Golgi Network Transport Vesicle Golgi To Vacuole Transport Vesicle-mediated Transport To The Plasma Membrane Amyloid-beta Metabolic Process
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