ADRA2B and PPP1R9B

Number of citations of the paper that reports this interaction (PubMedID 11154706)
0

Data Source:
BioGRID (pull down)

		ADRA2B	PPP1R9B
Description		adrenoceptor alpha 2B	protein phosphatase 1 regulatory subunit 9B
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell Surface Membrane	Protein Phosphatase Type 1 Complex Nucleus Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Lamellipodium Filopodium Dendrite Growth Cone Cortical Actin Cytoskeleton Ruffle Membrane Dendritic Spine Membrane Cell Projection Neuronal Cell Body Dendritic Spine Dendritic Spine Neck Dendritic Spine Head Synapse Anchoring Junction Spine Apparatus Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse Plasma Membrane Bounded Cell Projection Cytoplasmic Side Of Dendritic Spine Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Protein Binding Epinephrine Binding	Actin Binding Protein Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Kinase Binding D2 Dopamine Receptor Binding Transmembrane Transporter Binding Protein-containing Complex Binding Actin Filament Binding
	Biological Process	Regulation Of Vascular Associated Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Platelet Activation Negative Regulation Of Epinephrine Secretion Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Blood Pressure Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway	Regulation Of Cell Growth By Extracellular Stimulus Response To Amphetamine Developmental Process Involved In Reproduction Actin Filament Organization Regulation Of Exit From Mitosis Nervous System Development Learning RNA Splicing Response To Xenobiotic Stimulus Dendrite Development Cell Migration Calcium-mediated Signaling Hippocampus Development Cerebral Cortex Development Actin Filament Depolymerization Cell Differentiation Negative Regulation Of Cell Growth Neuron Projection Development Response To Estradiol Response To Prostaglandin E Response To Nicotine Response To Immobilization Stress Regulation Of Cell Population Proliferation Response To Amino Acid Filopodium Assembly Response To Steroid Hormone Regulation Of Cell Cycle Male Mating Behavior Reproductive System Development Cellular Response To Morphine Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Xenobiotic Stimulus Regulation Of Postsynapse Assembly Cellular Response To Peptide Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Actin Cytoskeleton Positive Regulation Of Protein Localization Positive Regulation Of Protein Localization To Actin Cortical Patch Response To Kainic Acid Response To L-phenylalanine Derivative Protein Localization To Cell Periphery Regulation Of Opioid Receptor Signaling Pathway
Pathways		Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor G alpha (i) signalling events G alpha (z) signalling events
Drugs		Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Etomidate Dihydroergotamine Clozapine Norepinephrine Phenylpropanolamine Loxapine Prochlorperazine Prazosin Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Clonidine Lisuride Guanabenz Epinephrine Tizanidine Apomorphine Paroxetine Trimipramine Risperidone Tolazoline Fenoldopam Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Guanfacine Ergoloid mesylate Promethazine Carvedilol Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine Dextroamphetamine Metamfetamine Celiprolol Dronedarone Rotigotine OPC-28326 Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Esmirtazapine Xylometazoline Levonordefrin Tetryzoline Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine Xylazine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Monocyte percentage of white cells ( 32888494)	Platelet distribution width ( 32888494) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		8 interacting genes: EIF2B1 GGA1 GGA2 GGA3 GNAI2 PPP1R9B UCHL1 YWHAZ	29 interacting genes: ACTA1 ACTN2 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C CCKAR CCKBR CDKN2A CHRM3 DCX DRD2 ITGB8 LRRC7 MAPK1 MECOM PPP1CA PPP1R2 PPP1R9A PRKACA RB1 RBL1 RBL2 RGS2 RPS6KB1 SHANK3 TGOLN2 TIAM1
Entrez ID		151	84687
HPRD ID		00086	04506
Ensembl ID		ENSG00000274286	ENSG00000108819
Uniprot IDs		P18089	Q96SB3
PDB IDs		6K41 6K42
Enriched GO Terms of Interacting Partners?		Ubiquitin Binding Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Protein Localization To Cell Periphery Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Vesicle-mediated Transport To The Plasma Membrane Trans-Golgi Network Protein Localization To Plasma Membrane Early Endosome Membrane Establishment Of Protein Localization To Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Hippocampal Mossy Fiber To CA3 Synapse Endosome Membrane Small GTPase Binding Golgi Vesicle Transport Cellular Response To Xenobiotic Stimulus Establishment Of Localization In Cell Protein Localization To Membrane Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Synaptic Target Recognition Intracellular Protein Localization Protein Metabolic Process Axon Target Recognition Omega Peptidase Activity Male Germ Cell Proliferation D2 Dopamine Receptor Binding Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Opioid Receptor Signaling Pathway Cellular Response To Morphine Eukaryotic Translation Initiation Factor 2B Complex Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Alpha-2A Adrenergic Receptor Binding Positive Regulation Of Catabolic Process Intracellular Transport Transmembrane Transporter Binding Golgi Reassembly Localization Within Membrane Intracellular Protein Transport Positive Regulation Of Lysosomal Protein Catabolic Process Protein Localization To Actin Cytoskeleton Response To Kainic Acid Dendritic Spine Head	Adrenergic Receptor Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Negative Regulation Of Catecholamine Secretion Alpha2-adrenergic Receptor Activity Regulation Of Muscle System Process Intracellular Signaling Cassette Regulation Of Blood Circulation G Protein-coupled Receptor Activity Signal Transduction Regulation Of System Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Lipid Kinase Activity Intracellular Signal Transduction Negative Regulation Of Epinephrine Secretion Regulation Of Vasoconstriction Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Regulation Of Amine Transport System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Catecholamine Secretion Regulation Of Biological Quality Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Norepinephrine Secretion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Muscle Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Developmental Process Phospholipase C-activating Adrenergic Receptor Signaling Pathway Cholecystokinin Receptor Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Hormone Secretion Dendritic Spine Positive Regulation Of Signal Transduction Regulation Of Tube Size Blood Vessel Diameter Maintenance Regulation Of Intracellular Signal Transduction Alpha1-adrenergic Receptor Activity Cholecystokinin Signaling Pathway Regulation Of Insulin Secretion ERBB Signaling Pathway Positive Regulation Of Cellular Component Organization
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