ADRA2B and PPP1R9B

Number of citations of the paper that reports this interaction (PMID 11154706)
28

Data Source:
BioGRID (pull down)

		ADRA2B	PPP1R9B
Gene Name		adrenoceptor alpha 2B	protein phosphatase 1, regulatory subunit 9B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Protein Phosphatase Type 1 Complex Nucleoplasm Cytoplasm Plasma Membrane Adherens Junction Lamellipodium Filopodium Cortical Actin Cytoskeleton Ruffle Membrane Dendritic Spine Synapse
	Molecular Function	Alpha2-adrenergic Receptor Activity Protein Binding Epinephrine Binding	Actin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding
	Biological Process	MAPK Cascade Angiogenesis Regulation Of Vascular Smooth Muscle Contraction G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Blood Coagulation Negative Regulation Of Norepinephrine Secretion Platelet Activation Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Neuron Differentiation Positive Regulation Of Blood Pressure Positive Regulation Of Uterine Smooth Muscle Contraction Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway	Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Protein Phosphorylation Actin Filament Organization Cell Cycle Arrest Regulation Of Exit From Mitosis RNA Splicing Dendrite Development Cell Migration Calcium-mediated Signaling Negative Regulation Of Cell Growth Regulation Of Cell Proliferation Negative Regulation Of Catalytic Activity Filopodium Assembly Regulation Of Synaptic Transmission Cellular Response To Morphine Regulation Of Opioid Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Adrenaline signalling through Alpha-2 adrenergic receptor Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Platelet Aggregation (Plug Formation) GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Adrenoceptors G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation
Drugs		Bethanidine Ziprasidone Cabergoline Ropinirole Etomidate Olanzapine Clozapine Norepinephrine Pramipexole Brimonidine Clonidine Lisuride Epinephrine Ergotamine Tizanidine Apomorphine Trimipramine Risperidone Fenoldopam Phenoxybenzamine Doxepin Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra Yohimbine Methotrimeprazine Methamphetamine Dronedarone Rotigotine Asenapine Droxidopa Xylometazoline
Diseases
GWAS
Protein-Protein Interactions		5 interactors: EIF2B1 GNAI2 PPP1R9B UCHL1 YWHAZ	23 interactors: ACTA1 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C CCKAR CCKBR CDKN2A CHRM3 DCX DRD2 MAPK1 PPP1CA PPP1CB PPP1CC PPP1R2 PPP1R9A PRKACA RGS2 RPS6KB1 TGOLN2 TIAM1
Entrez ID		151	84687
HPRD ID		00086	04506
Ensembl ID		ENSG00000222040	ENSG00000108819
Uniprot IDs		A2RUS0 P18089	D3DTX6 Q96SB3
PDB IDs		2CVA
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Opioid Receptor Signaling Pathway Regulation Of Catalytic Activity Cellular Response To Morphine Platelet Activation Golgi Reassembly Axon Target Recognition Cellular Response To Isoquinoline Alkaloid Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Axon Transport Of Mitochondrion Histamine Secretion By Mast Cell Negative Regulation Of Translational Initiation In Response To Stress Regulation Of Signaling Establishment Of Golgi Localization Golgi Inheritance Regulation Of Phosphorylation Regulation Of Synaptic Transmission Negative Regulation Of Translation In Response To Stress Histamine Secretion Response To Stress Regulation Of Phosphorus Metabolic Process Regulation Of Translational Initiation In Response To Stress Histamine Transport Regulation Of Exit From Mitosis Adenosine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Blood Coagulation Neurogenesis Hemostasis Golgi Localization Regulation Of Translation In Response To Stress Response To Extracellular Stimulus Filopodium Assembly Cell Development Negative Regulation Of Translational Initiation Mast Cell Degranulation Cellular Response To Ammonium Ion Intracellular Signal Transduction Production Of Molecular Mediator Involved In Inflammatory Response Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Lyase Activity Response To Stimulus Mast Cell Mediated Immunity Regulation Of Body Fluid Levels Lysosome Localization	Energy Reserve Metabolic Process Adrenergic Receptor Signaling Pathway Regulation Of Signaling Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Regulation Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Signaling Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Cell Communication Negative Regulation Of Signaling Regulation Of MAPK Cascade Generation Of Precursor Metabolites And Energy Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Regulation Of Hormone Secretion Triglyceride Catabolic Process Positive Regulation Of MAPK Cascade Regulation Of Phosphorylation Receptor Transactivation Acylglycerol Catabolic Process Developmental Process Negative Regulation Of Epinephrine Secretion Response To External Stimulus Regulation Of Kinase Activity Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Glycogen Catabolic Process G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Norepinephrine Secretion Response To Organic Substance Response To Stimulus Positive Regulation Of Signal Transduction Muscle System Process Regulation Of Intracellular Signal Transduction Activation Of Protein Kinase Activity Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Cellular Localization Regulation Of Protein Kinase Activity Regulation Of MAP Kinase Activity System Development Anatomical Structure Development Regulation Of Norepinephrine Secretion Negative Regulation Of Signal Transduction Response To Abiotic Stimulus
Tagcloud ?		adra1a adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill	accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation retardation syndrome transcriptome trinucleotide unc13b untranslated
Tagcloud (Difference) ?		adra1a adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill	accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation retardation syndrome transcriptome trinucleotide unc13b untranslated
Tagcloud (Intersection) ?