ADRA2B and EIF2B1

Number of citations of the paper that reports this interaction (PMID 9235896)
9

Data Source:
HPRD (in vitro, in vivo)

		ADRA2B	EIF2B1
Gene Name		adrenoceptor alpha 2B	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane
	Molecular Function	Alpha2-adrenergic Receptor Activity Protein Binding Epinephrine Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding GDP Binding Enzyme Regulator Activity S-methyl-5-thioribose-1-phosphate Isomerase Activity
	Biological Process	MAPK Cascade Angiogenesis Regulation Of Vascular Smooth Muscle Contraction G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Blood Coagulation Negative Regulation Of Norepinephrine Secretion Platelet Activation Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Neuron Differentiation Positive Regulation Of Blood Pressure Positive Regulation Of Uterine Smooth Muscle Contraction Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway	Translation Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development L-methionine Biosynthetic Process From Methylthioadenosine Negative Regulation Of Translational Initiation In Response To Stress Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Cellular Response To Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Adrenaline signalling through Alpha-2 adrenergic receptor Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Platelet Aggregation (Plug Formation) GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Adrenoceptors G alpha (z) signalling events G alpha (i) signalling events Platelet activation, signaling and aggregation	Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation
Drugs		Bethanidine Ziprasidone Cabergoline Ropinirole Etomidate Olanzapine Clozapine Norepinephrine Pramipexole Brimonidine Clonidine Lisuride Epinephrine Ergotamine Tizanidine Apomorphine Trimipramine Risperidone Fenoldopam Phenoxybenzamine Doxepin Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra Yohimbine Methotrimeprazine Methamphetamine Dronedarone Rotigotine Asenapine Droxidopa Xylometazoline
Diseases
GWAS
Protein-Protein Interactions		5 interactors: EIF2B1 GNAI2 PPP1R9B UCHL1 YWHAZ	14 interactors: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D CREBBP EIF2B2 EIF2B5 EIF2S1 EIF2S2 GORASP2 MRPL4 RD3 WDYHV1
Entrez ID		151	1967
HPRD ID		00086	09458
Ensembl ID		ENSG00000222040
Uniprot IDs		A2RUS0 P18089	Q14232
PDB IDs		2CVA	3ECS
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Opioid Receptor Signaling Pathway Regulation Of Catalytic Activity Cellular Response To Morphine Platelet Activation Golgi Reassembly Axon Target Recognition Cellular Response To Isoquinoline Alkaloid Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Axon Transport Of Mitochondrion Histamine Secretion By Mast Cell Negative Regulation Of Translational Initiation In Response To Stress Regulation Of Signaling Establishment Of Golgi Localization Golgi Inheritance Regulation Of Phosphorylation Regulation Of Synaptic Transmission Negative Regulation Of Translation In Response To Stress Histamine Secretion Response To Stress Regulation Of Phosphorus Metabolic Process Regulation Of Translational Initiation In Response To Stress Histamine Transport Regulation Of Exit From Mitosis Adenosine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Blood Coagulation Neurogenesis Hemostasis Golgi Localization Regulation Of Translation In Response To Stress Response To Extracellular Stimulus Filopodium Assembly Cell Development Negative Regulation Of Translational Initiation Mast Cell Degranulation Cellular Response To Ammonium Ion Intracellular Signal Transduction Production Of Molecular Mediator Involved In Inflammatory Response Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Lyase Activity Response To Stimulus Mast Cell Mediated Immunity Regulation Of Body Fluid Levels Lysosome Localization	Adrenergic Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Receptor Transactivation Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Regulation Of Smooth Muscle Contraction Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Norepinephrine Secretion Negative Regulation Of Smooth Muscle Contraction Translational Initiation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Muscle Contraction Negative Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of ERBB Signaling Pathway Activation Of Protein Kinase B Activity Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Muscle Contraction Positive Regulation Of Receptor Activity Response To Temperature Stimulus Regulation Of Vasoconstriction Positive Regulation Of Protein Kinase Activity Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Kinase Activity Negative Regulation Of Hormone Secretion Regulation Of Translational Initiation Positive Regulation Of Catalytic Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transferase Activity Regulation Of Translational Initiation In Response To Stress Regulation Of ERBB Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Translation Regulation Of Translation In Response To Stress Response To Heat Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Receptor Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Reproductive Process Regulation Of Kinase Activity Activation Of MAPK Activity Positive Regulation Of Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Protein Metabolic Process Negative Regulation Of Secretion By Cell
Tagcloud ?		adra1a adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill	1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm
Tagcloud (Difference) ?		adra1a adrenergic arg347cys bk2r check chronotropic dbp enos exercise glu298asp melting neurohumoral nitric overt paulo polymorphisms programme reserve rs1048101 rs1799983 rs2070744 rs28365031 rs553668 rs5810761 sao sbp synthase treadmill	1223t 3days 4months 584g antenatal ataxia cach cle cree deterioration exome hypomyelination i408t infantile lethargy leukoencephalopathy optic patch poliovirus r195h resembling resides spasticity vanishing vomiting vwm
Tagcloud (Intersection) ?