ADRA2B and GNAI2

Number of citations of the paper that reports this interaction (PubMedID 2169434)
0

Data Source:
HPRD (in vivo)

		ADRA2B	GNAI2
Description		adrenoceptor alpha 2B	G protein subunit alpha i2
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell Surface Membrane	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Dendrite Midbody Ciliary Basal Body Cell Body Extracellular Exosome Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle Extracellular Vesicle
	Molecular Function	G Protein-coupled Receptor Activity Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Protein Binding Epinephrine Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Regulation Of Vascular Associated Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Platelet Activation Negative Regulation Of Epinephrine Secretion Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Blood Pressure Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway	G Protein-coupled Adenosine Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Nutrient Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Urine Volume Negative Regulation Of Calcium Ion-dependent Exocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor G alpha (i) signalling events G alpha (z) signalling events	Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs		Amphetamine Tramadol Bethanidine Ziprasidone Cabergoline Ropinirole Etomidate Dihydroergotamine Clozapine Norepinephrine Phenylpropanolamine Loxapine Prochlorperazine Prazosin Chlorpromazine Brimonidine Haloperidol Nortriptyline Amoxapine Clonidine Lisuride Guanabenz Epinephrine Tizanidine Apomorphine Paroxetine Trimipramine Risperidone Tolazoline Fenoldopam Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Guanfacine Ergoloid mesylate Promethazine Carvedilol Desipramine Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra sinica root Mephentermine Yohimbine Methotrimeprazine Dextroamphetamine Metamfetamine Celiprolol Dronedarone Rotigotine OPC-28326 Epicept NP-1 Mianserin Pizotifen Asenapine Ocaperidone Droxidopa Esmirtazapine Xylometazoline Levonordefrin Tetryzoline Dosulepin Etoperidone Lorpiprazole Cirazoline Moxisylyte Aranidipine Setiptiline Racepinephrine Dihydroergocornine DL-Methylephedrine Xylazine Indigotindisulfonic acid Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases			Adrenal carcinoma
GWAS		Monocyte percentage of white cells ( 32888494)	Body mass index ( 26426971) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Morning person ( 30696823) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		8 interacting genes: EIF2B1 GGA1 GGA2 GGA3 GNAI2 PPP1R9B UCHL1 YWHAZ	66 interacting genes: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CRYAA CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NLA NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PCP2 PLSCR1 PTEN PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TNFAIP3 TRIP6 TSHR TTC1 TUBA4A
Entrez ID		151	2771
HPRD ID		00086	00764
Ensembl ID		ENSG00000274286	ENSG00000114353
Uniprot IDs		P18089	B3KP24 B3KX51 P04899
PDB IDs		6K41 6K42	6D9H 7F8V 7LD3 7LD4 7WV9 7WVV 7WVW 7WVX 7WVY 7XXI 7YJ4 7YK6 7YK7 8K6M 8K6N 8K6O 8KGG 8THK 8THL 8Y45 8ZSJ 8ZSP 8ZSS 8ZSV
Enriched GO Terms of Interacting Partners?		Ubiquitin Binding Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Protein Localization To Cell Periphery Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Vesicle-mediated Transport To The Plasma Membrane Trans-Golgi Network Protein Localization To Plasma Membrane Early Endosome Membrane Establishment Of Protein Localization To Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Hippocampal Mossy Fiber To CA3 Synapse Endosome Membrane Small GTPase Binding Golgi Vesicle Transport Cellular Response To Xenobiotic Stimulus Establishment Of Localization In Cell Protein Localization To Membrane Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Synaptic Target Recognition Intracellular Protein Localization Protein Metabolic Process Axon Target Recognition Omega Peptidase Activity Male Germ Cell Proliferation D2 Dopamine Receptor Binding Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Opioid Receptor Signaling Pathway Cellular Response To Morphine Eukaryotic Translation Initiation Factor 2B Complex Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Alpha-2A Adrenergic Receptor Binding Positive Regulation Of Catabolic Process Intracellular Transport Transmembrane Transporter Binding Golgi Reassembly Localization Within Membrane Intracellular Protein Transport Positive Regulation Of Lysosomal Protein Catabolic Process Protein Localization To Actin Cytoskeleton Response To Kainic Acid Dendritic Spine Head	G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Negative Regulation Of Signal Transduction Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of MAPK Cascade Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway System Process Signaling Regulation Of Blood Circulation Cell Communication Positive Regulation Of Cell Communication Regulation Of Metal Ion Transport Positive Regulation Of MAPK Cascade Positive Regulation Of Signaling Nervous System Process Positive Regulation Of Monoatomic Ion Transport GTPase Regulator Activity Response To Stress Cell-cell Signaling Vascular Process In Circulatory System Negative Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Locomotion Regulation Of Smooth Muscle Contraction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Vasoconstriction Regulation Of System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Blood Pressure Regulation Of Intracellular Signal Transduction
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