PUS10 and NECAB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PUS10	NECAB2
Description		pseudouridine synthase 10	N-terminal EF-hand calcium binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Cytoplasm Plasma Membrane Membrane Axon Dendrite Cell Projection Presynapse Postsynapse
	Molecular Function	RNA Binding Protein Binding Pseudouridine Synthase Activity Isomerase Activity Metal Ion Binding Primary MiRNA Binding TRNA Pseudouridine Synthase Activity TRNA Pseudouridine(55) Synthase Activity	Calcium Ion Binding Protein Binding A2A Adenosine Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Pseudouridine Synthesis TRNA Processing RNA Modification Primary MiRNA Processing TRNA Pseudouridine Synthesis	Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Adenosine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Protein Localization To Membrane
Pathways
Drugs
Diseases
GWAS		Atopic dermatitis ( 26482879) Celiac disease ( 22057235 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 22412388 28067908) Crohn's disease and celiac disease ( 21298027) Erectile dysfunction ( 30583798) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244) Ulcerative colitis ( 20228799 21297633 28067908)	Body mass index (change over time) ( 25378290) Corneal astigmatism ( 29422769) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Rheumatoid arthritis ( 30891314)
Interacting Genes		4 interacting genes: KRT14 KRT16 NECAB2 USP25	91 interacting genes: ADORA2A AIMP2 AIRIM BEX2 BEX3 BYSL C19orf25 C1orf216 CAGE1 CAPN3 CARD9 CCDC121 CCDC146 CCDC33 CCNK CDC37 CENPO CPEB2 DAXX DFFA DGCR6 DGCR6L DRC12 DTNBP1 DYNC1I2 EAF2 EHHADH EIF4E2 EMILIN1 FAM161A FAM161B FANCG FMR1 FXR1 FXR2 GCC1 GOLGA2 GTPBP10 HAUS1 INPP1 INTS10 ISCU KANK2 KANSL1 KDM1A KIFC3 KLC3 KLC4 KPNA2 LENG1 LNX1 MED14 MRPS27 MSGN1 MTCL2 MTMR9 MYO15B MYPOP NEK6 NIP7 NOC4L NTAQ1 ODAD3 ODAD4 OIP5 PATJ PICK1 POLR2C PRKAA2 PRPF18 PSMA1 PUS10 RCOR3 RIC8A RUNX1T1 SDCBP SH2D4A SMARCA2 SMARCD1 SNAPIN SSC5D TCEA2 TEX11 TRIM59 TRIML2 TSC1 TTR USHBP1 USP7 VTA1 ZNF655
Entrez ID		150962	54550
HPRD ID		08126	13263
Ensembl ID		ENSG00000162927	ENSG00000103154
Uniprot IDs		A8K6R4 Q3MIT2	Q7Z6G3
PDB IDs		2V9K
Enriched GO Terms of Interacting Partners?		Hair Cycle Cornified Envelope Structural Constituent Of Skin Epidermis Keratinocyte Differentiation Intermediate Filament Organization Structural Constituent Of Cytoskeleton Intermediate Filament Cytoskeleton Organization Keratin Filament Epidermal Cell Differentiation Intermediate Filament-based Process Epidermis Development Negative Regulation Of G Protein-coupled Receptor Internalization Intermediate Filament Structural Molecule Activity Negative Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding Ubiquitin-like Protein Peptidase Activity Keratin Filament Binding Keratinocyte Migration Interleukin-17A-mediated Signaling Pathway Negative Regulation Of ERAD Pathway Intermediate Filament Bundle Assembly Morphogenesis Of An Epithelium Negative Regulation Of Response To Oxidative Stress Positive Regulation Of Glutamate Receptor Signaling Pathway SUMO Binding Regulation Of Glutamate Receptor Signaling Pathway Epithelial Cell Differentiation Tissue Morphogenesis Basal Part Of Cell Negative Regulation Of Receptor Internalization Regulation Of Amyloid Precursor Protein Biosynthetic Process Supramolecular Fiber Organization Protein K63-linked Deubiquitination Regulation Of ERAD Pathway Deubiquitinase Activity Protein K48-linked Deubiquitination Regulation Of Response To Oxidative Stress Negative Regulation Of Receptor-mediated Endocytosis Epithelial Cell Migration Establishment Of Skin Barrier Regulation Of Glycoprotein Biosynthetic Process Skin Epidermis Development Tissue Development Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Response To Endoplasmic Reticulum Stress	Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Translation Regulator Activity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Presynaptic Modulation Of Chemical Synaptic Transmission Cytoplasm Microtubule Outer Dynein Arm Docking Complex Cellular Component Assembly Microtubule-based Movement Spermatid Development Regulation Of DNA-templated Transcription Elongation RNA Strand Annealing Activity Regulation Of Long-term Neuronal Synaptic Plasticity Organelle Assembly Ribosome Biogenesis Positive Regulation Of Receptor Internalization
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