PUS10

Description		pseudouridine synthase 10
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol
	Molecular Function	RNA Binding Protein Binding Pseudouridine Synthase Activity Isomerase Activity Metal Ion Binding Primary MiRNA Binding TRNA Pseudouridine Synthase Activity TRNA Pseudouridine(55) Synthase Activity
	Biological Process	Pseudouridine Synthesis TRNA Processing RNA Modification Primary MiRNA Processing TRNA Pseudouridine Synthesis
Pathways
Drugs
Diseases
GWAS		Atopic dermatitis ( 26482879) Celiac disease ( 22057235 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 22412388 28067908) Crohn's disease and celiac disease ( 21298027) Erectile dysfunction ( 30583798) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244) Ulcerative colitis ( 20228799 21297633 28067908)
Interacting Genes		4 interacting genes: KRT14 KRT16 NECAB2 USP25
Entrez ID		150962
HPRD ID		08126
Ensembl ID		ENSG00000162927
Uniprot IDs		A8K6R4 Q3MIT2
PDB IDs		2V9K
Enriched GO Terms of Interacting Partners?		Hair Cycle Cornified Envelope Structural Constituent Of Skin Epidermis Keratinocyte Differentiation Intermediate Filament Organization Structural Constituent Of Cytoskeleton Intermediate Filament Cytoskeleton Organization Keratin Filament Epidermal Cell Differentiation Intermediate Filament-based Process Epidermis Development Negative Regulation Of G Protein-coupled Receptor Internalization Intermediate Filament Structural Molecule Activity Negative Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding Ubiquitin-like Protein Peptidase Activity Keratin Filament Binding Keratinocyte Migration Interleukin-17A-mediated Signaling Pathway Negative Regulation Of ERAD Pathway Intermediate Filament Bundle Assembly Morphogenesis Of An Epithelium Negative Regulation Of Response To Oxidative Stress Positive Regulation Of Glutamate Receptor Signaling Pathway SUMO Binding Regulation Of Glutamate Receptor Signaling Pathway Epithelial Cell Differentiation Tissue Morphogenesis Basal Part Of Cell Negative Regulation Of Receptor Internalization Regulation Of Amyloid Precursor Protein Biosynthetic Process Supramolecular Fiber Organization Protein K63-linked Deubiquitination Regulation Of ERAD Pathway Deubiquitinase Activity Protein K48-linked Deubiquitination Regulation Of Response To Oxidative Stress Negative Regulation Of Receptor-mediated Endocytosis Epithelial Cell Migration Establishment Of Skin Barrier Regulation Of Glycoprotein Biosynthetic Process Skin Epidermis Development Tissue Development Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Response To Endoplasmic Reticulum Stress
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