PUS10 and KRT16

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PUS10	KRT16
Description		pseudouridine synthase 10	keratin 16
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Cornified Envelope Nucleus Cytosol Cytoskeleton Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Pseudouridine Synthase Activity Isomerase Activity Metal Ion Binding Primary MiRNA Binding TRNA Pseudouridine Synthase Activity TRNA Pseudouridine(55) Synthase Activity	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Pseudouridine Synthesis TRNA Processing RNA Modification Primary MiRNA Processing TRNA Pseudouridine Synthesis	Morphogenesis Of An Epithelium Inflammatory Response Cytoskeleton Organization Keratinocyte Differentiation Negative Regulation Of Cell Migration Keratinization Hair Cycle Innate Immune Response Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Keratinocyte Migration Establishment Of Skin Barrier
Pathways			Keratinization Formation of the cornified envelope
Drugs			Zinc Zinc acetate
Diseases			Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex Non-epidermolytic palmoplantar keratoderma (NEPPK)
GWAS		Atopic dermatitis ( 26482879) Celiac disease ( 22057235 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 22412388 28067908) Crohn's disease and celiac disease ( 21298027) Erectile dysfunction ( 30583798) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244) Ulcerative colitis ( 20228799 21297633 28067908)
Interacting Genes		4 interacting genes: KRT14 KRT16 NECAB2 USP25	53 interacting genes: AIRIM AMOT ARFIP2 C1orf216 CARD9 CCDC146 CCDC17 CCHCR1 CCNC CDK18 CYTH4 DRC4 EPM2AIP1 GNG10 HGS KIFC3 KLC4 KRT1 KRT6C KRT71 KRT72 KRT73 KRT74 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 LMO1 LNX1 MBD3 PKN1 POLL PPP1R18 PRKAA2 PRPH PUS10 SEMA4C SGF29 SMARCD1 SMARCE1 SNAPIN TCHP TSG101 TTC23 TXLNB USHBP1
Entrez ID		150962	3868
HPRD ID		08126	01018
Ensembl ID		ENSG00000162927	ENSG00000186832
Uniprot IDs		A8K6R4 Q3MIT2	P08779
PDB IDs		2V9K
Enriched GO Terms of Interacting Partners?		Hair Cycle Cornified Envelope Structural Constituent Of Skin Epidermis Keratinocyte Differentiation Intermediate Filament Organization Structural Constituent Of Cytoskeleton Intermediate Filament Cytoskeleton Organization Keratin Filament Epidermal Cell Differentiation Intermediate Filament-based Process Epidermis Development Negative Regulation Of G Protein-coupled Receptor Internalization Intermediate Filament Structural Molecule Activity Negative Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding Ubiquitin-like Protein Peptidase Activity Keratin Filament Binding Keratinocyte Migration Interleukin-17A-mediated Signaling Pathway Negative Regulation Of ERAD Pathway Intermediate Filament Bundle Assembly Morphogenesis Of An Epithelium Negative Regulation Of Response To Oxidative Stress Positive Regulation Of Glutamate Receptor Signaling Pathway SUMO Binding Regulation Of Glutamate Receptor Signaling Pathway Epithelial Cell Differentiation Tissue Morphogenesis Basal Part Of Cell Negative Regulation Of Receptor Internalization Regulation Of Amyloid Precursor Protein Biosynthetic Process Supramolecular Fiber Organization Protein K63-linked Deubiquitination Regulation Of ERAD Pathway Deubiquitinase Activity Protein K48-linked Deubiquitination Regulation Of Response To Oxidative Stress Negative Regulation Of Receptor-mediated Endocytosis Epithelial Cell Migration Establishment Of Skin Barrier Regulation Of Glycoprotein Biosynthetic Process Skin Epidermis Development Tissue Development Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Response To Endoplasmic Reticulum Stress	Intermediate Filament Organization Keratin Filament Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Protein Binding Cytosol
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