PUS10 and USP25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PUS10	USP25
Description		pseudouridine synthase 10	ubiquitin specific peptidase 25
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol
	Molecular Function	RNA Binding Protein Binding Pseudouridine Synthase Activity Isomerase Activity Metal Ion Binding Primary MiRNA Binding TRNA Pseudouridine Synthase Activity TRNA Pseudouridine(55) Synthase Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin-like Protein Peptidase Activity Ubiquitin Protein Ligase Binding SUMO Binding Ubiquitin Binding ATPase Binding Deubiquitinase Activity
	Biological Process	Pseudouridine Synthesis TRNA Processing RNA Modification Primary MiRNA Processing TRNA Pseudouridine Synthesis	Proteolysis Protein Deubiquitination Regulation Of Protein Stability Cellular Response To Oxidative Stress Protein Modification Process Interleukin-17A-mediated Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Response To Oxidative Stress Negative Regulation Of Interleukin-17-mediated Signaling Pathway Negative Regulation Of ERAD Pathway
Pathways			Ub-specific processing proteases
Drugs
Diseases
GWAS		Atopic dermatitis ( 26482879) Celiac disease ( 22057235 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 22412388 28067908) Crohn's disease and celiac disease ( 21298027) Erectile dysfunction ( 30583798) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244) Ulcerative colitis ( 20228799 21297633 28067908)	Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Severe autoimmune type 2 diabetes ( 34737425) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		4 interacting genes: KRT14 KRT16 NECAB2 USP25	37 interacting genes: ACTA1 ARMC8 CDC73 CNTN1 EIF4A3 FBXL17 FLNC GAPDH GDI1 MAGEB4 MAVS MID2 MT2A NAP1L3 PAX6 PUS10 RAD23A RAD23B RPS10-NUDT3 RSL1D1 SENP1 SKIL SNRNP70 SUMO1 SUMO2 SUMO3 SYK TMEM43 TNKS TNKS2 TUBB UBC UBE2I VPS45 YARS1 ZNF426 ZNF841
Entrez ID		150962	29761
HPRD ID		08126	05296
Ensembl ID		ENSG00000162927	ENSG00000155313
Uniprot IDs		A8K6R4 Q3MIT2	Q9UHP3
PDB IDs		2V9K	2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM
Enriched GO Terms of Interacting Partners?		Hair Cycle Cornified Envelope Structural Constituent Of Skin Epidermis Keratinocyte Differentiation Intermediate Filament Organization Structural Constituent Of Cytoskeleton Intermediate Filament Cytoskeleton Organization Keratin Filament Epidermal Cell Differentiation Intermediate Filament-based Process Epidermis Development Negative Regulation Of G Protein-coupled Receptor Internalization Intermediate Filament Structural Molecule Activity Negative Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Type 5 Metabotropic Glutamate Receptor Binding Ubiquitin-like Protein Peptidase Activity Keratin Filament Binding Keratinocyte Migration Interleukin-17A-mediated Signaling Pathway Negative Regulation Of ERAD Pathway Intermediate Filament Bundle Assembly Morphogenesis Of An Epithelium Negative Regulation Of Response To Oxidative Stress Positive Regulation Of Glutamate Receptor Signaling Pathway SUMO Binding Regulation Of Glutamate Receptor Signaling Pathway Epithelial Cell Differentiation Tissue Morphogenesis Basal Part Of Cell Negative Regulation Of Receptor Internalization Regulation Of Amyloid Precursor Protein Biosynthetic Process Supramolecular Fiber Organization Protein K63-linked Deubiquitination Regulation Of ERAD Pathway Deubiquitinase Activity Protein K48-linked Deubiquitination Regulation Of Response To Oxidative Stress Negative Regulation Of Receptor-mediated Endocytosis Epithelial Cell Migration Establishment Of Skin Barrier Regulation Of Glycoprotein Biosynthetic Process Skin Epidermis Development Tissue Development Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Response To Endoplasmic Reticulum Stress	Presynaptic Cytosol Protein Tag Activity Protein Sumoylation Postsynaptic Cytosol Nucleus Post-translational Protein Modification Protein Modification By Small Protein Conjugation PML Body Protein Poly-ADP-ribosylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Ubiquitin-like Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Small Protein Activating Enzyme Binding Positive Regulation Of Telomere Capping Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Glutamatergic Synapse Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity Regulation Of Telomere Capping Protein Localization To Organelle Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Cytosol Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Proteasome Binding Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-specific Protease Binding Cellular Response To Cadmium Ion SUMO Transferase Activity Transcription Factor Binding Nuclear Pore NAD+-protein Mono-ADP-ribosyltransferase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Response To Cytokine
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