CCL21 and DCTN3

		CCL21	DCTN3
Description		C-C motif chemokine ligand 21	dynactin subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Chromosome, Centromeric Region Kinetochore Chromosome Nucleolus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Dynactin Complex Microtubule Associated Complex Midbody Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CCR7 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding	Structural Molecule Activity Protein Binding
	Biological Process	Establishment Of T Cell Polarity Immunological Synapse Formation Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of T Cell Chemotaxis Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Ruffle Organization Killing Of Cells Of Another Organism Positive Regulation Of Cell Adhesion Mediated By Integrin Mesangial Cell-matrix Adhesion Chemokine (C-C Motif) Ligand 21 Signaling Pathway CCL21-activated CCR7 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade Eosinophil Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Neutrophil Chemotaxis Dendritic Cell Dendrite Assembly Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Negative Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Chemokine Positive Regulation Of Cell Motility Positive Regulation Of T Cell Migration Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process	Mitotic Cell Cycle Microtubule-based Process Cell Division Cytoskeleton-dependent Cytokinesis
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Blood protein levels ( 30072576) Celiac disease ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Rheumatoid arthritis ( 18794853 23143596 24390342 30423114 30572963) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Appendicular lean mass ( 33097823)
Interacting Genes		32 interacting genes: ACKR2 ACKR4 C3orf52 CCL13 CCL17 CCL23 CCL24 CCL26 CCL28 CCL5 CCR7 CTSD CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL17 CXCL2 CXCL9 GOT2 IGFBP7 LRRK1 OTP PF4 PF4V1 PPBP TMEM107 UBQLN4 VCAN XCL1 XCL2	11 interacting genes: ATXN1 DCTN1 GSK3B KRT34 NUP54 PBX2 PITX1 TRIM55 TRIP13 USHBP1 VPS37C
Entrez ID		6366	11258
HPRD ID		04113	06303
Ensembl ID		ENSG00000137077	ENSG00000137100
Uniprot IDs		O00585	O75935 X6RLR1
PDB IDs		2L4N 5EKI
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Antimicrobial Humoral Response Cytokine Activity Leukocyte Chemotaxis Humoral Immune Response Chemokine-mediated Signaling Pathway Myeloid Leukocyte Migration Leukocyte Migration Cell Migration Granulocyte Chemotaxis CXCR Chemokine Receptor Binding Cell Motility Killing Of Cells Of Another Organism Granulocyte Migration Inflammatory Response Cell Killing Cytokine-mediated Signaling Pathway Defense Response To Symbiont Immune Response Defense Response To Other Organism Extracellular Space Mononuclear Cell Migration Immune System Process Defense Response Neutrophil Chemotaxis Extracellular Region Response To Other Organism Response To External Biotic Stimulus Neutrophil Migration CXCR3 Chemokine Receptor Binding CCR Chemokine Receptor Binding G Protein-coupled Receptor Signaling Pathway Lymphocyte Chemotaxis Chemokine Receptor Binding Lymphocyte Migration Cell-cell Signaling Signaling Cell Communication Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Regulation Of Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Response To Molecule Of Bacterial Origin Positive Regulation Of Cell Motility	Regulation Of Dendritic Cell Dendrite Assembly CCR7 Chemokine Receptor Binding Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Establishment Of T Cell Polarity Negative Regulation Of Dendritic Cell Apoptotic Process Chemokine Receptor Binding Establishment Of Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Mononuclear Cell Migration Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Glycoprotein Biosynthetic Process Cellular Response To Prostaglandin E Stimulus Eosinophil Chemotaxis Positive Regulation Of Glycoprotein Metabolic Process Eosinophil Migration Myeloid Leukocyte Migration Regulation Of Antigen Processing And Presentation Dendritic Cell Migration Positive Regulation Of Neutrophil Chemotaxis Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Cell Maturation Positive Regulation Of Granulocyte Chemotaxis CCR Chemokine Receptor Binding Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Neutrophil Migration Regulation Of Neutrophil Chemotaxis Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cellular Component Biogenesis Neuron Projection Organization Tau Protein Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Maturation Regulation Of Neutrophil Migration T Cell Costimulation Chemokine Activity Leukocyte Migration Regulation Of Cell Projection Assembly Regulation Of Granulocyte Chemotaxis Regulation Of Microtubule Anchoring At Centrosome Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Dendritic Cell Dendrite Assembly Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Leukocyte Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Recognition
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?