CCL21

Gene Name		chemokine (C-C motif) ligand 21
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Chemokine Activity CCR7 Chemokine Receptor Binding Chemokine Receptor Binding
	Biological Process	Establishment Of T Cell Polarity Immunological Synapse Formation Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Ruffle Organization Activation Of Rho GTPase Activity Positive Regulation Of Cell Adhesion Mediated By Integrin Response To Prostaglandin E Mesangial Cell-matrix Adhesion Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Dendritic Cell Dendrite Assembly Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of T Cell Migration Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Dendrite Assembly
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 18794853 20453842)
Protein-protein Interactions		10 interactors: ACKR2 ACKR4 CCR10 CCR7 CTSD CXCL13 GOT2 IGFBP7 UBQLN4 VCAN
Entrez ID		6366
HPRD ID		04113
Ensembl ID		ENSG00000137077
Uniprot IDs		O00585 Q6ICR7
PDB IDs		2L4N
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Chemotaxis Locomotion Response To Cytokine Response To Organic Substance Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Neutrophil Activation Cellular Response To Organic Substance Cytosolic Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Lymphocyte Migration Immune System Process Immune Response Regulation Of Humoral Immune Response Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Activation Of Ras GTPase Activity Positive Regulation Of Leukocyte Chemotaxis Receptor-mediated Endocytosis Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-C Motif) Ligand 19 Signaling Pathway Lymphocyte Chemotaxis Across High Endothelial Venule Positive Regulation Of Immunological Synapse Formation Endothelial Cell Chemotaxis To Fibroblast Growth Factor B Cell Chemotaxis Across High Endothelial Venule Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Lymphocyte Migration Into Lymph Node Response To External Stimulus Cellular Metal Ion Homeostasis Positive Regulation Of Leukocyte Migration Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Interleukin-12 Secretion Activation Of Rap GTPase Activity Positive Regulation Of T Cell Costimulation Leukocyte Chemotaxis Leukocyte Activation Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Cellular Chemical Homeostasis Cell Recognition Positive Regulation Of Behavior
Tagcloud ?		aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl20 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger