CCL21 and GOT2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		CCL21	GOT2
Gene Name		chemokine (C-C motif) ligand 21	glutamic-oxaloacetic transaminase 2, mitochondrial
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Chemokine Activity CCR7 Chemokine Receptor Binding Chemokine Receptor Binding	L-aspartate:2-oxoglutarate Aminotransferase Activity Kynurenine-oxoglutarate Transaminase Activity Pyridoxal Phosphate Binding Poly(A) RNA Binding L-phenylalanine:2-oxoglutarate Aminotransferase Activity
	Biological Process	Establishment Of T Cell Polarity Immunological Synapse Formation Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Ruffle Organization Activation Of Rho GTPase Activity Positive Regulation Of Cell Adhesion Mediated By Integrin Response To Prostaglandin E Mesangial Cell-matrix Adhesion Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Dendritic Cell Dendrite Assembly Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of T Cell Migration Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Dendrite Assembly	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Cellular Amino Acid Biosynthetic Process Pathogenesis Fatty Acid Transport 4-hydroxyproline Catabolic Process Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Response To Ethanol L-kynurenine Metabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Amino acid synthesis and interconversion (transamination) Metabolism of carbohydrates Metabolism of amino acids and derivatives
Drugs			Pyridoxal Phosphate L-Aspartic Acid L-Glutamic Acid 4\'-Deoxy-4\'-Acetylyamino-Pyridoxal-5\'-Phosphate
Diseases
GWAS		Rheumatoid arthritis ( 18794853 20453842)	Aortic root size ( 21223598) QT interval ( 19305408)
Protein-Protein Interactions		10 interactors: ACKR2 ACKR4 CCR10 CCR7 CTSD CXCL13 GOT2 IGFBP7 UBQLN4 VCAN	10 interactors: APCS CCL21 GAPDH GLRX GLUD1 HSPA8 MDH2 PC THOC7 ZDHHC6
Entrez ID		6366	2806
HPRD ID		04113	00684
Ensembl ID		ENSG00000137077	ENSG00000125166
Uniprot IDs		O00585 Q6ICR7	E7ERW2 P00505
PDB IDs		2L4N
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Chemotaxis Locomotion Response To Cytokine Response To Organic Substance Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Neutrophil Activation Cellular Response To Organic Substance Cytosolic Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Lymphocyte Migration Immune System Process Immune Response Regulation Of Humoral Immune Response Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Activation Of Ras GTPase Activity Positive Regulation Of Leukocyte Chemotaxis Receptor-mediated Endocytosis Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-C Motif) Ligand 19 Signaling Pathway Lymphocyte Chemotaxis Across High Endothelial Venule Positive Regulation Of Immunological Synapse Formation Endothelial Cell Chemotaxis To Fibroblast Growth Factor B Cell Chemotaxis Across High Endothelial Venule Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Lymphocyte Migration Into Lymph Node Response To External Stimulus Cellular Metal Ion Homeostasis Positive Regulation Of Leukocyte Migration Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Interleukin-12 Secretion Activation Of Rap GTPase Activity Positive Regulation Of T Cell Costimulation Leukocyte Chemotaxis Leukocyte Activation Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Cellular Chemical Homeostasis Cell Recognition Positive Regulation Of Behavior	Gluconeogenesis Hexose Biosynthetic Process Dicarboxylic Acid Metabolic Process Oxaloacetate Metabolic Process Glucose Metabolic Process Carbohydrate Biosynthetic Process Pathogenesis Hexose Metabolic Process Monosaccharide Metabolic Process Tricarboxylic Acid Metabolic Process Protein Deglutathionylation Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Dendrite Assembly Dendritic Cell Dendrite Assembly Negative Regulation Of Fibril Organization Peptidyl-cysteine S-trans-nitrosylation Carboxylic Acid Metabolic Process Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Mesangial Cell-matrix Adhesion Negative Regulation Of Exo-alpha-sialidase Activity Organic Acid Metabolic Process Pyruvate Metabolic Process Regulation Of Dendritic Cell Dendrite Assembly Regulation Of Fibril Organization Small Molecule Metabolic Process Negative Regulation Of Leukocyte Tethering Or Rolling Clathrin Coat Disassembly Peptidyl-cysteine S-nitrosylation Establishment Of T Cell Polarity Oxidation-reduction Process Negative Regulation Of Monocyte Differentiation Glutamate Catabolic Process Positive Regulation Of Dendritic Cell Chemotaxis Cellular Metabolic Process Positive Regulation Of Transport Viral MRNA Export From Host Cell Nucleus Glutamate Biosynthetic Process Cellular Protein Metabolic Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Locomotion Biotin Metabolic Process Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Dicarboxylic Acid Catabolic Process Chaperone-mediated Protein Complex Assembly Protein Folding Regulation Of Monocyte Differentiation Dendritic Cell Chemotaxis
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Tagcloud (Difference) ?		aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl20 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger	aggravating anxa1 banks bedside confidently cons fth1 ftl gliosis immunochemical infarct infarcted infarcts itraq lagging leak malate mdh2 mortem plex pros proteome proteomics putamen shuttle slc25a11 slc25a12 tca vim
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