CCL21 and CCR7

Number of citations of the paper that reports this interaction (PMID 9585422)
57

Data Source:
HPRD (in vivo)

		CCL21	CCR7
Gene Name		chemokine (C-C motif) ligand 21	chemokine (C-C motif) receptor 7
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Intracellular Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Chemokine Activity CCR7 Chemokine Receptor Binding Chemokine Receptor Binding	G-protein Coupled Receptor Activity C-C Chemokine Receptor Activity Chemokine (C-C Motif) Ligand 19 Binding Chemokine (C-C Motif) Ligand 21 Binding C-C Motif Chemokine 19 Receptor Activity C-C Motif Chemokine 21 Receptor Activity
	Biological Process	Establishment Of T Cell Polarity Immunological Synapse Formation Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Ruffle Organization Activation Of Rho GTPase Activity Positive Regulation Of Cell Adhesion Mediated By Integrin Response To Prostaglandin E Mesangial Cell-matrix Adhesion Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Dendritic Cell Dendrite Assembly Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of T Cell Migration Positive Regulation Of Myeloid Dendritic Cell Chemotaxis Negative Regulation Of Dendritic Cell Dendrite Assembly	Establishment Of T Cell Polarity Positive Regulation Of Cell-matrix Adhesion Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Hypersensitivity Positive Regulation Of Humoral Immune Response Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Ruffle Organization Response To Lipopolysaccharide Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Activation Of Rho GTPase Activity Response To Prostaglandin E Chemokine (C-C Motif) Ligand 19 Signaling Pathway Chemokine (C-C Motif) Ligand 21 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Thymic T Cell Selection Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of T Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Filopodium Assembly Positive Regulation Of Protein Kinase B Signaling Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Response To Nitric Oxide Interleukin-12 Secretion Positive Regulation Of Neutrophil Chemotaxis Lymphocyte Migration Into Lymph Node Mature Conventional Dendritic Cell Differentiation Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Chemotaxis Positive Regulation Of Immunological Synapse Formation Positive Regulation Of T Cell Costimulation Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Regulation Of Dendritic Cell Dendrite Assembly
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 18794853 20453842)
Protein-Protein Interactions		10 interactors: ACKR2 ACKR4 CCR10 CCR7 CTSD CXCL13 GOT2 IGFBP7 UBQLN4 VCAN	3 interactors: CCL19 CCL21 CCR10
Entrez ID		6366	1236
HPRD ID		04113	02588
Ensembl ID		ENSG00000137077	ENSG00000126353
Uniprot IDs		O00585 Q6ICR7	A0N0Q0 P32248
PDB IDs		2L4N
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Chemotaxis Locomotion Response To Cytokine Response To Organic Substance Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Neutrophil Activation Cellular Response To Organic Substance Cytosolic Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Lymphocyte Migration Immune System Process Immune Response Regulation Of Humoral Immune Response Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Activation Of Ras GTPase Activity Positive Regulation Of Leukocyte Chemotaxis Receptor-mediated Endocytosis Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-C Motif) Ligand 19 Signaling Pathway Lymphocyte Chemotaxis Across High Endothelial Venule Positive Regulation Of Immunological Synapse Formation Endothelial Cell Chemotaxis To Fibroblast Growth Factor B Cell Chemotaxis Across High Endothelial Venule Positive Regulation Of Glycoprotein Biosynthetic Process Involved In Immunological Synapse Formation Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Lymphocyte Migration Into Lymph Node Response To External Stimulus Cellular Metal Ion Homeostasis Positive Regulation Of Leukocyte Migration Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Interleukin-12 Secretion Activation Of Rap GTPase Activity Positive Regulation Of T Cell Costimulation Leukocyte Chemotaxis Leukocyte Activation Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Cellular Chemical Homeostasis Cell Recognition Positive Regulation Of Behavior	Regulation Of Dendritic Cell Dendrite Assembly Establishment Of T Cell Polarity Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Cytosolic Calcium Ion Homeostasis Dendritic Cell Chemotaxis Immunological Synapse Formation Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Glycoprotein Metabolic Process Response To Prostaglandin E Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Neutrophil Chemotaxis Dendritic Cell Migration Positive Regulation Of Granulocyte Chemotaxis Positive Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Glycoprotein Biosynthetic Process Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Cellular Metal Ion Homeostasis Inflammatory Response Cellular Cation Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Granulocyte Chemotaxis Cellular Ion Homeostasis Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Sequestering Of Calcium Ion Metal Ion Homeostasis Leukocyte Activation Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Cellular Chemical Homeostasis Regulation Of Phosphatidylinositol 3-kinase Activity Ion Homeostasis Negative Regulation Of Leukocyte Apoptotic Process Chemotaxis Regulation Of Lipid Kinase Activity Cell-cell Recognition Positive Regulation Of Leukocyte Chemotaxis Cell Activation Cellular Homeostasis Response To Fatty Acid T Cell Costimulation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Leukocyte Migration Chemical Homeostasis Leukocyte Chemotaxis Positive Regulation Of Endocytosis Positive Regulation Of Chemotaxis Establishment Of Cell Polarity
Tagcloud ?		aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl20 chemokine chemokines chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger	capture ccr1 ccr2 ccr5 cd40 chemokine chemokines cxcr1 cxcr4 dc dendritic ebi1 elc immature inflamed insight lost lymphoid marginally maturation mature maturing migrate nodes organs phases respective responded responsiveness
Tagcloud (Difference) ?		aaa aaas adventitial aneurysms aorta arteries atherosclerosis atherothrombosis atherothrombotic ccl19 ccl20 chemotaxis conditioned contributors converted cryosections cxcl13 cxcl16 evolutive immunofluorescence medium qpcr sma smcs tertiary tlos trigger	capture ccr1 ccr2 ccr5 cd40 cxcr1 cxcr4 dc dendritic ebi1 elc immature inflamed insight lost lymphoid marginally maturation mature maturing migrate nodes organs phases respective responded responsiveness
Tagcloud (Intersection) ?		chemokine chemokines